2P54

a crystal structure of PPAR alpha bound with SRC1 peptide and GW735

Summary for 2P54

Entry DOI	10.2210/pdb2p54/pdb
Descriptor	Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID, ... (4 entities in total)
Functional Keywords	ppar alpha gw735 src1 agonist hdlc, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q07869 Nucleus (By similarity): Q15788
Total number of polymer chains	2
Total formula weight	32267.71
Authors	Xu, R.X.,Xu, H.E.,Sierra, M.L.,Montana, V.G.,Lambert, M.H.,Pianetti, P.M. (deposition date: 2007-03-14, release date: 2007-04-24, Last modification date: 2024-04-03)
Primary citation	Sierra, M.L.,Beneton, V.,Boullay, A.B.,Boyer, T.,Brewster, A.,Donche, F.,Forest, M.C.,Fouchet, M.H.,Gellibert, F.J.,Grillot, D.A.,Lambert, M.H.,Laroze, A.,Grumelec, C.L.,Linget, J.M.,Montana, V.G.,Nguyen, V.L.,Nicodeme, E.,Patel, V.,Penfornis, A.,Pineau, O.,Pohin, D.,Potvain, F.,Paulain, G.,Ruault, C.B.,Saunders, M.,Toum, J.,Xu, H.E.,Xu, R.X.,Pianetti, P.M. Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents. J.Med.Chem., 50:685-695, 2007 Cited by PubMed: 17243659 DOI: 10.1021/jm058056x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation