1Y0S

Crystal structure of PPAR delta complexed with GW2331

Summary for 1Y0S

DescriptorPeroxisome proliferator activated receptor delta, IODIDE ION, (2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREIDO)ETHYL]PHENOXY)-2-METHYLBUTYRIC ACID, ... (5 entities in total)
Functional Keywordsppar, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q03181
Total number of polymer chains2
Total molecular weight65162.15
Authors
Takada, I.,Yu, R.T.,Xu, H.E.,Xu, R.X.,Lambert, M.H.,Montana, V.G.,Kliewer, S.A.,Evans, R.M.,Umesono, K. (deposition date: 2004-11-16, release date: 2005-03-29, Last modification date: 2011-07-13)
Primary citation
Takada, I.,Yu, R.T.,Xu, H.E.,Lambert, M.H.,Montana, V.G.,Kliewer, S.A.,Evans, R.M.,Umesono, K.
Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) Generates a PPAR delta Phenotype
MOL.ENDOCRINOL., 14:733-740, 2000
PubMed: 10809235 (PDB entries with the same primary citation)
DOI: 10.1210/me.14.5.733
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256161.6%2.7%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1y0s
no rotation
Molmil generated image of 1y0s
rotated about x axis by 90°
Molmil generated image of 1y0s
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 1y0s
no rotation
Molmil generated image of 1y0s
rotated about x axis by 90°
Molmil generated image of 1y0s
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1y0s.pdb1.gz [47.85 KB])
Coordinate files for Biological unit (1y0s.pdb2.gz [46.64 KB])