4XKL | | CRYSTAL STRUCTURE OF NDP52 ZF2 IN COMPLEX WITH MONO-UBIQUITIN | | Descriptor: | Ubiquitin, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ... | | Authors: | Xie, X., Li, F., Wang, Y., Lin, Z., Chen, X., Liu, J., Pan, L. | | Deposit date: | 2015-01-12 | | Release date: | 2015-11-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
Autophagy, 11, 2015
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1JNK | |
1JUO | |
1TAF | | DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER | | Descriptor: | TFIID TBP ASSOCIATED FACTOR 42, TFIID TBP ASSOCIATED FACTOR 62, ZINC ION | | Authors: | Xie, X., Kokubo, T., Cohen, S.L., Mirza, U.A., Hoffmann, A., Chait, B.T., Roeder, R.G., Nakatani, Y., Burley, S.K. | | Deposit date: | 1996-06-01 | | Release date: | 1996-12-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural similarity between TAFs and the heterotetrameric core of the histone octamer.
Nature, 380, 1996
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1TKQ | | SOLUTION STRUCTURE OF A LINKED UNSYMMETRIC GRAMICIDIN IN A MEMBRANE-ISOELECTRICAL SOLVENTS MIXTURE IN THE PRESENCE OF CSCL | | Descriptor: | MINI-GRAMICIDIN A, GRAMICIDIN A, SUCCINIC ACID | | Authors: | Xie, X., Al-Momani, L., Bockelmann, D., Griesinger, C., Koert, U. | | Deposit date: | 2004-06-09 | | Release date: | 2004-07-13 | | Last modified: | 2012-12-12 | | Method: | SOLUTION NMR | | Cite: | An Asymmetric Ion Channel Derived from Gramicidin A. Synthesis, Function and NMR Structure.
FEBS J., 272, 2005
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5SUN | | IDH1 R132H IN COMPLEX WITH IDH146 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide, ... | | Authors: | Xie, X., Kulathila, R. | | Deposit date: | 2016-08-03 | | Release date: | 2017-02-08 | | Last modified: | 2017-03-22 | | Method: | X-RAY DIFFRACTION (2.477 Å) | | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
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5SVF | | IDH1 R132H IN COMPLEX WITH IDH125 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, ... | | Authors: | Xie, X., Kulathila, R. | | Deposit date: | 2016-08-05 | | Release date: | 2017-02-08 | | Last modified: | 2017-03-22 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
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5SVN | | STRUCTURE OF IDH2 MUTANT R172K | | Descriptor: | Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Xie, X., Kulathila, R. | | Deposit date: | 2016-08-06 | | Release date: | 2017-02-08 | | Last modified: | 2017-03-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
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5SVO | | STRUCTURE OF IDH2 MUTANT R140Q | | Descriptor: | Isocitrate dehydrogenase [NADP], mitochondrial, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Xie, X., Kulathila, R. | | Deposit date: | 2016-08-06 | | Release date: | 2017-02-08 | | Last modified: | 2017-03-22 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Structure, 25, 2017
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5TF9 | | CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH MN2+AMPPNP AND WNK476 | | Descriptor: | Serine/threonine-protein kinase WNK1, {2-[(4-chlorophenyl)methoxy]phenyl}{5-[2-(methylamino)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indol-1-yl}methanone, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Xie, X., Gunawan, J. | | Deposit date: | 2016-09-24 | | Release date: | 2016-10-19 | | Last modified: | 2016-12-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
ACS Chem. Biol., 11, 2016
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3SUZ | | CRYSTAL STRUCTURE OF RAT MINT2 PPC | | Descriptor: | Amyloid beta A4 precursor protein-binding family A member 2 | | Authors: | Shen, Y., Long, J., Yan, X., Xie, X. | | Deposit date: | 2011-07-11 | | Release date: | 2012-07-11 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Open-closed motion of Mint2 regulates APP metabolism
J Mol Cell Biol, 5, 2013
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3SV1 | | CRYSTAL STRUCTURE OF APP PEPTIDE BOUND RAT MINT2 PARM | | Descriptor: | Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein | | Authors: | Shen, Y., Long, J., Yan, X., Xie, X. | | Deposit date: | 2011-07-12 | | Release date: | 2012-07-11 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Open-closed motion of Mint2 regulates APP metabolism
J Mol Cell Biol, 5, 2013
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2MXP | |
1PME | |
1SCM | |
2OJG | |
2OJI | |
2OJJ | |
2OK1 | |
3G90 | |
4IEH | |
5TQH | | IDH1 R132H MUTANT IN COMPLEX WITH IDH889 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, CITRATE ANION, (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one, ... | | Authors: | Xie, X., Kulathila, R. | | Deposit date: | 2016-10-24 | | Release date: | 2017-01-25 | | Last modified: | 2017-03-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.
ACS Med Chem Lett, 8, 2017
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5WDY | |
5WE8 | |
6B0Z | | IDH1 R132H MUTANT IN COMPLEX WITH IDH305 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one, ... | | Authors: | Xie, X., Kulathila, R. | | Deposit date: | 2017-09-15 | | Release date: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.334 Å) | | Cite: | Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.
ACS Med Chem Lett, 8, 2017
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