5TQH
IDH1 R132H mutant in complex with IDH889
Summary for 5TQH
Entry DOI | 10.2210/pdb5tqh/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, CITRATE ANION, (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one, ... (5 entities in total) |
Functional Keywords | isocitrate dehydrogenase, rossmann fold, nadph, inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 4 |
Total formula weight | 193133.58 |
Authors | Xie, X.,Kulathila, R. (deposition date: 2016-10-24, release date: 2017-01-25, Last modification date: 2024-03-06) |
Primary citation | Levell, J.R.,Caferro, T.,Chenail, G.,Dix, I.,Dooley, J.,Firestone, B.,Fortin, P.D.,Giraldes, J.,Gould, T.,Growney, J.D.,Jones, M.D.,Kulathila, R.,Lin, F.,Liu, G.,Mueller, A.,van der Plas, S.,Slocum, K.,Smith, T.,Terranova, R.,Toure, B.B.,Tyagi, V.,Wagner, T.,Xie, X.,Xu, M.,Yang, F.S.,Zhou, L.X.,Pagliarini, R.,Cho, Y.S. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett, 8:151-156, 2017 Cited by PubMed: 28197303DOI: 10.1021/acsmedchemlett.6b00334 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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