5TQH
IDH1 R132H mutant in complex with IDH889
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 417 | 46912.4 | 4 | UniProt (O75874) Pfam (PF00180) In PDB | Homo sapiens (Human) | IDH,Cytosolic NADP-isocitrate dehydrogenase,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase |
2 | A, B, C, D | CITRATE ANION | non-polymer | 189.1 | 4 | Chemie (FLC) | |||
3 | A, B, C, D | (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one | non-polymer | 436.5 | 4 | Chemie (7J2) | |||
4 | A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
5 | water | water | 18.0 | 634 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 414 (UniProt: O75874)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Pro -1 | - | expression tag |
Gly 0 | - | expression tag |
His 132 | Arg 132 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 187649.6 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 5484.0 | |
All* | Total formula weight | 193133.6 |