5TQH
IDH1 R132H mutant in complex with IDH889
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 417 | 46912.4 | 4 | UniProt (O75874) Pfam (PF00180) | Homo sapiens (Human) | IDH,Cytosolic NADP-isocitrate dehydrogenase,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase |
| 2 | E, I, L, O (A, B, C, D) | CITRATE ANION | non-polymer | 189.1 | 4 | Chemie (FLC) | |||
| 3 | F, H, K, N (A, B, C, D) | (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one | non-polymer | 436.5 | 4 | Chemie (7J2) | |||
| 4 | G, J, M, P (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 634 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 414 (UniProt: O75874)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| His 132 | Arg 132 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 187649.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5484.0 | |
| All* | Total formula weight | 193133.6 |
