1JNK

THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP

Summary for 1JNK

Entry DOI	10.2210/pdb1jnk/pdb
Descriptor	C-JUN N-TERMINAL KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	transferase, jnk3 map kinase, serine/threonine protein kinase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P53779
Total number of polymer chains	1
Total formula weight	49116.82
Authors	Xie, X.,Su, M.S.-S. (deposition date: 1998-06-03, release date: 1999-06-08, Last modification date: 2024-02-07)
Primary citation	Xie, X.,Gu, Y.,Fox, T.,Coll, J.T.,Fleming, M.A.,Markland, W.,Caron, P.R.,Wilson, K.P.,Su, M.S. Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. Structure, 6:983-991, 1998 Cited by PubMed Abstract: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. Activation and nuclear localization of JNK3, a neuronal-specific isoform of JNK, has been associated with hypoxic and ischemic damage of CA1 neurons in the hippocampus. Knockout mice lacking JNK3 showed reduced apoptosis of hippocampal neurons and reduced seizure induced by kainic acid, a glutamate-receptor agonist. Thus, JNK3 may be important in the pathology of neurological disorders and is of significant medical interest. PubMed: 9739089 DOI: 10.1016/S0969-2126(98)00100-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation