1JNK

THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004705	molecular_function	JUN kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0004708	molecular_function	MAP kinase kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0007254	biological_process	JNK cascade
A	0009416	biological_process	response to light stimulus
A	0016020	cellular_component	membrane
A	0016310	biological_process	phosphorylation
A	0033554	biological_process	cellular response to stress
A	0038095	biological_process	Fc-epsilon receptor signaling pathway
A	0042752	biological_process	regulation of circadian rhythm
A	0048511	biological_process	rhythmic process
A	0090398	biological_process	cellular senescence
A	0106310	molecular_function	protein serine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	ASN194
A	ANP1001
A	MG1003
A	HOH2044
A	HOH2094

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1003

Chain	Residue
A	ASN194
A	ANP1001
A	MG1002
A	HOH2151

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site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ANP A 1001

Chain	Residue
A	ILE70
A	GLY71
A	SER72
A	GLY73
A	ALA74
A	GLN75
A	GLY76
A	VAL78
A	ALA91
A	LYS93
A	GLU147
A	MET149
A	ASN152
A	LYS191
A	SER193
A	ASN194
A	LEU206
A	MG1002
A	MG1003
A	HOH2001
A	HOH2014
A	HOH2044
A	HOH2151

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV

Chain	Residue	Details
A	ILE185-VAL197

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site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC

Chain	Residue	Details
A	PHE99-CYS201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	ASP189

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	ILE70
A	LYS93

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:10715136

Chain	Residue	Details
A	THR221

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:10715136

Chain	Residue	Details
A	TYR223

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP189
A	SER193

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP189
A	LYS191

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR226
A	ASP189
A	LYS191

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site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP189
A	LYS191
A	ASN194

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