8VRT

The structure of LSD1-CoREST-HDAC1 in complex with KBTBD4R313PRR mutant

Summary for 8VRT

• Entry DOI: 10.2210/pdb8vrt/pdb
• EMDB information: 43487
• Descriptor: Kelch repeat and BTB domain-containing protein 4, Histone deacetylase 1, REST corepressor 1, ... (5 entities in total)
• Functional Keywords: protein degradation, e3 ligase, neo-substrate, cancer mutation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 218804.91

Authors

Xie, X.,Liau, B.,Zheng, N. (deposition date: 2024-01-22, release date: 2024-11-27)

• Primary citation: Xie, X.,Liau, B.,Zheng, N.; Molecular Mechanism Underlying KBTBD4 Cancer Mutation-Driven Degradation of HDAC Corepressor Complexes; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.42 Å)