8VRT
The structure of LSD1-CoREST-HDAC1 in complex with KBTBD4R313PRR mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kelch repeat and BTB domain-containing protein 4 | polymer | 520 | 58463.1 | 2 | UniProt (Q9NVX7) Pfam (PF00651) Pfam (PF07707) Pfam (PF07646) | Homo sapiens (human) | BTB and kelch domain-containing protein 4 |
| 2 | C (C) | Histone deacetylase 1 | polymer | 482 | 55178.9 | 1 | UniProt (Q13547) Pfam (PF00850) | Homo sapiens (human) | HD1,Protein deacetylase HDAC1,Protein decrotonylase HDAC1 |
| 3 | D (D) | REST corepressor 1 | polymer | 401 | 45974.4 | 1 | UniProt (Q9UKL0) Pfam (PF01448) Pfam (PF00249) Pfam (PF20878) | Homo sapiens (human) | Protein CoREST |
| 4 | E (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F (D) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) |
Sequence modifications
A, B: 17 - 536 (UniProt: Q9NVX7)
D: -18 - 381 (UniProt: Q9UKL0)
| PDB | External Database | Details |
|---|---|---|
| Pro 311 | - | insertion |
| Arg 312 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 218079.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 725.4 | |
| All* | Total formula weight | 218804.9 |
