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3DLL
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BU of 3dll by Molmil
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Descriptor: 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Wilson, D.N, Schluenzen, F, Harms, J.M, Starosta, A.L, Connell, S.R, Fucini, P.
Deposit date:2008-06-27
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Proc.Natl.Acad.Sci.Usa, 105, 2008
1Y69
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BU of 1y69 by Molmil
RRF domain I in complex with the 50S ribosomal subunit from Deinococcus radiodurans
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L16, 50S ribosomal protein L27, ...
Authors:Wilson, D.N, Schluenzen, F, Harms, J.M, Yoshida, T, Ohkubo, T, Albrecht, R, Buerger, J, Kobayashi, Y, Fucini, P.
Deposit date:2004-12-04
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:X-ray crystallography on ribosome recycling: mechanism of binding and action of RRF on the 50S ribosomal subunit
EMBO J., 24, 2005
6HTQ
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BU of 6htq by Molmil
Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Wilson, D.N, Abdelshahid, M.
Deposit date:2018-10-04
Release date:2019-10-23
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Cell Rep, 32, 2020
4V6I
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BU of 4v6i by Molmil
Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein RACK1 (RACK1), ...
Authors:Armache, J.-P, Jarasch, A, Anger, A.M, Villa, E, Becker, T, Bhushan, S, Jossinet, F, Habeck, M, Dindar, G, Franckenberg, S, Marquez, V, Mielke, T, Thomm, M, Berninghausen, O, Beatrix, B, Soeding, J, Westhof, E, Wilson, D.N, Beckmann, R.
Deposit date:2010-10-12
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V6U
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BU of 4v6u by Molmil
Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10P, ...
Authors:Armache, J.-P, Anger, A.M, Marquez, V, Frankenberg, S, Froehlich, T, Villa, E, Berninghausen, O, Thomm, M, Arnold, G.J, Beckmann, R, Wilson, D.N.
Deposit date:2012-08-09
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution.
Nucleic Acids Res., 41, 2013
4V6X
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BU of 4v6x by Molmil
Structure of the human 80S ribosome
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R.
Deposit date:2013-02-27
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structures of the human and Drosophila 80S ribosome.
Nature, 497, 2013
4V5N
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BU of 4v5n by Molmil
tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST)
Descriptor: 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T.
Deposit date:2010-10-21
Release date:2014-07-09
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
4V7E
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BU of 4v7e by Molmil
Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S10E, ...
Authors:Barrio-Garcia, C, Armache, J.-P, Jarasch, A, Anger, A.M, Villa, E, Becker, T, Bhushan, S, Jossinet, F, Habeck, M, Dindar, G, Franckenberg, S, Marquez, V, Mielke, T, Thomm, M, Berninghausen, O, Beatrix, B, Soeding, J, Westhof, E, Wilson, D.N, Beckmann, R.
Deposit date:2013-11-22
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
Nature, 506, 2014
7P7U
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BU of 7p7u by Molmil
E. faecalis 70S ribosome with P-tRNA, state IV
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7T
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BU of 7p7t by Molmil
PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7Q
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BU of 7p7q by Molmil
E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7S
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BU of 7p7s by Molmil
PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7R
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BU of 7p7r by Molmil
PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-03-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7JQL
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BU of 7jql by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Mardirossian, M, Sola, R, Beckert, B, Valencic, E, Collis, D.W.P, Borisek, J, Armas, F, Di Stasi, A, Buchmann, J, Syroegin, E.A, Polikanov, Y.S, Magistrato, A, Hilpert, K, Wilson, D.N, Scocchi, M.
Deposit date:2020-08-11
Release date:2020-08-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.
J.Med.Chem., 63, 2020
7JQM
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BU of 7jqm by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Mardirossian, M, Sola, R, Beckert, B, Valencic, E, Collis, D.W.P, Borisek, J, Armas, F, Di Stasi, A, Buchmann, J, Syroegin, E.A, Polikanov, Y.S, Magistrato, A, Hilpert, K, Wilson, D.N, Scocchi, M.
Deposit date:2020-08-11
Release date:2020-08-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.
J.Med.Chem., 63, 2020
7OTC
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BU of 7otc by Molmil
Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B
Descriptor: 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ...
Authors:Wieland, M, Koller, T.O, Wilson, D.N.
Deposit date:2021-06-10
Release date:2022-05-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Proc.Natl.Acad.Sci.USA, 119, 2022
6S47
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BU of 6s47 by Molmil
Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1
Descriptor: 18S rRNA (1707-MER), 28S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Kasari, V, Pochopien, A.A, Margus, T, Murina, V, Turnbull, K, Zhou, Y, Nissan, T, Graf, M, Novacek, J, Atkinson, G.C, Johansson, M.J.O, Wilson, D.N, Hauryliuk, V.
Deposit date:2019-06-26
Release date:2019-07-24
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.
Nucleic Acids Res., 47, 2019
6SZS
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BU of 6szs by Molmil
Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Muller, C, Beckert, B, Wilson, D.N.
Deposit date:2019-10-02
Release date:2019-12-04
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis.
Nat Commun, 10, 2019
7AS9
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BU of 7as9 by Molmil
Bacillus subtilis ribosome-associated quality control complex state A. Ribosomal 50S subunit with peptidyl tRNA in the A/P position and RqcH.
Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2020-10-27
Release date:2020-12-23
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.
Mol.Cell, 81, 2021
7AS8
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BU of 7as8 by Molmil
Bacillus subtilis ribosome quality control complex state B. Ribosomal 50S subunit with P-tRNA, RqcH, and RqcP/YabO
Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2020-10-27
Release date:2020-12-09
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.
Mol.Cell, 81, 2021
7ASA
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BU of 7asa by Molmil
Bacillus subtilis ribosome-associated quality control complex state B, multibody refinement focussed on RqcH. Ribosomal 50S subunit with P-tRNA, RqcH, and RqcP/YabO
Descriptor: 23S rRNA, 50S ribosomal protein L11, Rqc2 homolog RqcH, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2020-10-27
Release date:2020-12-23
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.
Mol.Cell, 81, 2021
7B7D
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BU of 7b7d by Molmil
Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Ranjan, N, Pochopien, A.A, Wu, C.C, Beckert, B, Blanchet, S, Green, R, Rodnina, M.V, Wilson, D.N.
Deposit date:2020-12-10
Release date:2021-03-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:eEF3 promotes late stages of tRNA translocation including E-tRNA release from the ribosome
To Be Published
7AZY
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BU of 7azy by Molmil
Context-specific inhibition of eukaryotic translation by macrolide antibiotics
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Koller, T.O, Wilson, D.N.
Deposit date:2020-11-17
Release date:2021-05-19
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.877 Å)
Cite:Context-specific action of macrolide antibiotics on the eukaryotic ribosome.
Nat Commun, 12, 2021
7UG7
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BU of 7ug7 by Molmil
70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Rundlet, E.J, Wieland, M, Holm, M, Koller, T.O, Blanchard, S.C, Wilson, D.N.
Deposit date:2022-03-24
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Proc.Natl.Acad.Sci.USA, 119, 2022
5MLC
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BU of 5mlc by Molmil
Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions
Descriptor: 23S ribosomal RNA, chloroplastic, 4.8S ribosomal RNA, ...
Authors:Graf, M, Arenz, S, Huter, P, Doenhoefer, A, Novacek, J, Wilson, D.N.
Deposit date:2016-12-06
Release date:2016-12-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions.
Nucleic Acids Res., 45, 2017

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