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5TIM
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BU of 5tim by Molmil
REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.
J.Mol.Biol., 220, 1991
3TIM
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BU of 3tim by Molmil
THE CRYSTAL STRUCTURE OF THE "OPEN" AND THE "CLOSED" CONFORMATION OF THE FLEXIBLE LOOP OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE
Descriptor: TRIOSEPHOSPHATE ISOMERASE
Authors:Wierenga, R.K.
Deposit date:1990-05-15
Release date:1991-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase.
Proteins, 10, 1991
6ZIB
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BU of 6zib by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH ACETOACETYL-COA AND NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETOACETYL-COENZYME A, Peroxisomal bifunctional enzyme, ...
Authors:Wierenga, R.K, Sridhar, S, Kiema, T.R.
Deposit date:2020-06-25
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH ACETOACETYL-COA AND NADH
To Be Published
6ZIC
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BU of 6zic by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH 3S-HYDROXYBUTANOYL-COA AND NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3-HYDROXYBUTANOYL-COENZYME A, GLYCEROL, ...
Authors:Wierenga, R.K, Sridhar, S, Kiema, T.R.
Deposit date:2020-06-25
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH 3S-HYDROXYBUTANOYL-COA AND NADH
To Be Published
6HSP
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BU of 6hsp by Molmil
Crystal structure of the zebrafish peroxisomal SCP2-thiolase (type-1) in complex with CoA and octanoyl-CoA
Descriptor: COENZYME A, GLYCEROL, OCTANOYL-COENZYME A, ...
Authors:Wierenga, R.K, Kiema, T.R, Thapa, C.J.
Deposit date:2018-10-01
Release date:2019-01-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
6HSJ
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BU of 6hsj by Molmil
Crystal structure of the zebrafish peroxisomal SCP2-thiolase (type-1) in complex with CoA
Descriptor: ACETATE ION, COENZYME A, GLYCEROL, ...
Authors:Wierenga, R.K, Kiema, T.R, Thapa, C.J.
Deposit date:2018-10-01
Release date:2019-01-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
6HRV
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BU of 6hrv by Molmil
Crystal structure of the zebrafish peroxisomal SCP2-thiolase (type-1)
Descriptor: ACETATE ION, GLYCEROL, SCP2-thiolase (type-1)
Authors:Wierenga, R.K, Kiema, T.R, Thapa, C.J.
Deposit date:2018-09-28
Release date:2019-01-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
6Z5V
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BU of 6z5v by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH 3-KETODECANOYL-COA IN CROTONASE FOLD AND OXIDISED NICOTINAMIDE ADENINE DINUCLEOTIDE IN HAD FOLD
Descriptor: 3-KETO-DECANOYL-COA, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Wierenga, R.K, Sridhar, S, Kiema, T.R.
Deposit date:2020-05-27
Release date:2020-12-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites.
Acta Crystallogr D Struct Biol, 76, 2020
6Z5O
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BU of 6z5o by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH COENZYME-A AND OXIDISED NICOTINAMIDE ADENINE DINUCLEOTIDE
Descriptor: COENZYME A, GLYCEROL, NICOTINAMIDE, ...
Authors:Wierenga, R.K, Sridhar, S, Kiema, T.R.
Deposit date:2020-05-27
Release date:2020-12-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites.
Acta Crystallogr D Struct Biol, 76, 2020
6Z5F
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BU of 6z5f by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH 3-KETODECANOYL-COA AND OXIDISED NICOTINAMIDE ADENINE DINUCLEOTIDE
Descriptor: 3-KETO-DECANOYL-COA, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Wierenga, R.K, Sridhar, S, Kiema, T.R.
Deposit date:2020-05-26
Release date:2020-12-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites.
Acta Crystallogr D Struct Biol, 76, 2020
1DUB
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BU of 1dub by Molmil
2-ENOYL-COA HYDRATASE, DATA COLLECTED AT 100 K, PH 6.5
Descriptor: 2-ENOYL-COA HYDRATASE, ACETOACETYL-COENZYME A
Authors:Wierenga, R.K, Engel, C.K.
Deposit date:1996-06-10
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket.
EMBO J., 15, 1996
1TRI
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BU of 1tri by Molmil
THE CRYSTAL STRUCTURE OF AN ENGINEERED MONOMERIC TRIOSEPHOSPHATE ISOMERASE, MONOTIM: THE CORRECT MODELLING OF AN EIGHT-RESIDUE LOOP
Descriptor: SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Wierenga, R.K.
Deposit date:1993-10-08
Release date:1994-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of an engineered monomeric triosephosphate isomerase, monoTIM: the correct modelling of an eight-residue loop.
Structure, 1, 1993
4TIM
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BU of 4tim by Molmil
CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor: 2-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Nobel, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-11
Release date:1992-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
5OMO
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BU of 5omo by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH WITH 3S-HYDROXY-DECANOYL-COA AND 3-KETO-DECANOYL-COA
Descriptor: (S)-3-HYDROXYDECANOYL-COA, 3-KETO-DECANOYL-COA, GLYCEROL, ...
Authors:Kasaragod, P, Kiema, T.-R, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2017-08-01
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 3S-HYDROXY-DECANOYL-COA AND 3- KETO-DECANOYL-COA
Not Published
6TIM
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BU of 6tim by Molmil
THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor: SN-GLYCEROL-3-PHOSPHATE, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
5LOT
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BU of 5lot by Molmil
Crystal structure of SCP2 thiolase from Leishmania mexicana. Complex of the C123A mutant with acetyl-CoA.
Descriptor: 3-ketoacyl-CoA thiolase-like protein, ACETYL COENZYME *A
Authors:Harijan, R.K, Kiema, T.-R, Wierenga, R.K.
Deposit date:2016-08-09
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.
Protein Eng. Des. Sel., 30, 2017
5LNQ
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BU of 5lnq by Molmil
Crystal structure of SCP2 thiolase from Leishmania mexicana. Complex of the C123A mutant with acetoacetyl-CoA.
Descriptor: 3-ketoacyl-CoA thiolase-like protein, ACETOACETYL-COENZYME A
Authors:Harijan, R.K, Kiema, T.-R, Wierenga, R.K.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.
Protein Eng. Des. Sel., 30, 2017
7ZSC
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BU of 7zsc by Molmil
Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281)
Descriptor: Prolyl 4-hydroxylase subunit alpha-2, Protein disulfide-isomerase, SULFATE ION
Authors:Lebedev, A, Koski, M.K, Wierenga, R.K, Murthy, A.V, Sulu, R.
Deposit date:2022-05-06
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H alpha 2 beta 2 tetramer.
J.Biol.Chem., 298, 2022
5MGB
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BU of 5mgb by Molmil
Crystal Structure of Rat Peroxisomal Multifunctional enzyme Type-1 (RPMFE1) Complexed with Acetoacetyl-CoA and NAD
Descriptor: ACETOACETYL-COENZYME A, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kasaragod, P, Kiema, T.-R, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2016-11-21
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase part.
FEBS Open Bio, 7, 2017
6TNM
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BU of 6tnm by Molmil
E. coli aerobic trifunctional enzyme subunit-alpha
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Fatty acid oxidation complex subunit alpha, GLYCEROL, ...
Authors:Sah-Teli, S.K, Hynonen, M.J, Wierenga, R.K, Venkatesan, R.
Deposit date:2019-12-09
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Insights into the stability and substrate specificity of the E. coli aerobic beta-oxidation trifunctional enzyme complex.
J.Struct.Biol., 210, 2020
3PH9
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BU of 3ph9 by Molmil
Crystal structure of the human anterior gradient protein 3
Descriptor: Anterior gradient protein 3 homolog
Authors:Nguyen, V.D, Ruddock, L.W, Salin, M, Wierenga, R.K.
Deposit date:2010-11-03
Release date:2011-10-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structure of human anterior gradient protein 3.
Acta Crystallogr.,Sect.F, 74, 2018
4U1A
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BU of 4u1a by Molmil
Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase helix-10 deletion mutant (ISOB-ECI2)
Descriptor: CHLORIDE ION, Enoyl-CoA delta isomerase 2
Authors:Onwukwe, G.U, Koski, M.K, Wierenga, R.K.
Deposit date:2014-07-15
Release date:2014-12-24
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J., 282, 2015
4U19
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BU of 4u19 by Molmil
Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase V349A mutant (ISOA-ECI2)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Enoyl-CoA delta isomerase 2
Authors:Onwukwe, G.U, Koski, M.K, Wierenga, R.K.
Deposit date:2014-07-15
Release date:2014-12-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J., 282, 2015
4U18
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BU of 4u18 by Molmil
Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase (ISO-ECI2)
Descriptor: CHLORIDE ION, Enoyl-CoA delta isomerase 2, mitochondrial, ...
Authors:Onwukwe, G.U, Koski, M.K, Wierenga, R.K.
Deposit date:2014-07-15
Release date:2014-12-24
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J., 282, 2015
3ZBL
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BU of 3zbl by Molmil
Crystal structure of SCP2 thiolase from Leishmania mexicana: The C123S mutant.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, CHLORIDE ION, ...
Authors:Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K.
Deposit date:2012-11-10
Release date:2013-08-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013

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