7ZSC

Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281)

Summary for 7ZSC

Entry DOI	10.2210/pdb7zsc/pdb
Descriptor	Prolyl 4-hydroxylase subunit alpha-2, Protein disulfide-isomerase, SULFATE ION (3 entities in total)
Functional Keywords	collagen synthesis, pdi, dsbh fold, thioredoxin, dioxygenase, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	171764.48
Authors	Lebedev, A.,Koski, M.K.,Wierenga, R.K.,Murthy, A.V.,Sulu, R. (deposition date: 2022-05-06, release date: 2022-11-09, Last modification date: 2024-01-31)
Primary citation	Murthy, A.V.,Sulu, R.,Lebedev, A.,Salo, A.M.,Korhonen, K.,Venkatesan, R.,Tu, H.,Bergmann, U.,Janis, J.,Laitaoja, M.,Ruddock, L.W.,Myllyharju, J.,Koski, M.K.,Wierenga, R.K. Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H alpha 2 beta 2 tetramer. J.Biol.Chem., 298:102614-102614, 2022 Cited by PubMed: 36265586 DOI: 10.1016/j.jbc.2022.102614 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.85 Å)

Structure validation