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6E05
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE TRIPHOSPHATE SOLVED BY PRECIPITANT-LIGAND EXCHANGE (CRYSTALS GROWN IN SULFATE PRECIPITANT)
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-07-06
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6E06
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE TRIPHOSPHATE SOLVED BY PRECIPITANT-LIGAND EXCHANGE (CRYSTALS GROWN IN CITRATE PRECIPITANT)
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-07-06
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6CZB
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH URIDINE TRIPHOSPHATE (UTP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CZC
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH THYMIDINE TRIPHOSPHATE (TTP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CZD
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH ADENOSINE DIPHOSPHATE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6CZE
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH INOSINE TRIPHOSPHATE (ITP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, INOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVV
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH ADENOSINE TRIPHOSPHATE (ATP) - PROMISCUOUS BINDING MODE WITH DISORDERED NUCLEOSIDE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-03-29
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVE
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE TRIPHOSPHATE AND 7,8-DIAMINOPELARGONIC ACID
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thompson, A.P., Bruning, J.B., Wegener, K.L., Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVF
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE DIPHOSPHATE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P., Bruning, J.B., Wegener, K.L., Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVU
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE IN COMPLEX WITH CYTIDINE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE
Authors:Thompson, A.P., Wegener, K.L., Bruning, J.B., Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.426 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CIV
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LACTAM CYCLISED MIMETIC OF A FRAGMENT OF P21
Descriptor:p21
Authors:Wegener, K.L.
Deposit date:2018-02-25
Release date:2018-07-04
Last modified:2018-08-29
Method:SOLUTION NMR
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
6CIX
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LACTAM CYCLISED MIMETIC OF A FRAGMENT OF P21
Descriptor:p21
Authors:Wegener, K.L.
Deposit date:2018-02-25
Release date:2018-07-04
Last modified:2018-08-29
Method:SOLUTION NMR
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
6CEJ
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SOLUTION STRUCTURE OF A 14MER FRAGMENT OF THE P21 PROTEIN
Descriptor:Cyclin-dependent kinase inhibitor 1
Authors:Wegener, K.L.
Deposit date:2018-02-12
Release date:2018-07-04
Last modified:2018-08-29
Method:SOLUTION NMR
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
6CBI
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PCNA IN COMPLEX WITH INHIBITOR
Descriptor:Proliferating cell nuclear antigen, GLY-ARG-LYS-ARG-ARG-GLN-DAB-SER-MET-THR-GLU-PHE-TYR-HIS, SULFATE ION
Authors:Bruning, J.B., Wegener, K.L.
Deposit date:2018-02-03
Release date:2018-07-04
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
5TUP
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X-RAY CRYSTAL STRUCTURE OF THE ASPERGILLUS FUMIGATUS SLIDING CLAMP
Descriptor:Proliferating cell nuclear antigen
Authors:Bruning, J.B., Marshall, A.C., Kroker, A.J., Wegener, K.L., Rajapaksha, H.
Deposit date:2016-11-06
Release date:2017-02-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21.
FEBS J., 284, 2017
4WOP
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NUCLEOTIDE TRIPHOSPHATE PROMISCUITY IN MYCOBACTERIUM TUBERCULOSIS DETHIOBIOTIN SYNTHETASE
Descriptor:ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, SULFATE ION
Authors:Salaemae, W., Yap, M.Y., Wegener, K.L., Booker, G.W., Wilce, M.C.J., Polyak, S.W.
Deposit date:2014-10-16
Release date:2015-04-08
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
Tuberculosis (Edinb), 95, 2015
2KGX
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HADDOCK STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH TALIN 1655-1822
Descriptor:Talin-1, MKIAA1027 protein
Authors:Goult, B.T., Gingras, A.R., Bate, N., Critchley, D.R., Barsukov, I.L.
Deposit date:2009-03-23
Release date:2009-03-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
3G9W
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CRYSTAL STRUCTURE OF TALIN2 F2-F3 IN COMPLEX WITH THE INTEGRIN BETA1D CYTOPLASMIC TAIL
Descriptor:Talin-2, Integrin beta-1D, GLYCEROL, ...
Authors:Anthis, N.J., Wegener, K.L., Ye, F., Kim, C., Lowe, E.D., Vakonakis, I., Bate, N., Critchley, D.R., Ginsberg, M.H., Campbell, I.D.
Deposit date:2009-02-15
Release date:2009-10-20
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
2KBB
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NMR STRUCTURE OF THE TALIN ROD DOMAIN, 1655-1822
Descriptor:Talin-1
Authors:Goult, B.T., Gingras, A.R., Bate, N., Critchley, D.R., Barsukov, I.L.
Deposit date:2008-11-24
Release date:2009-03-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
2K00
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SOLUTION STRUCTURE OF THE TALIN F3 IN COMPLEX WITH LAYILIN CYTODOMAIN
Descriptor:Talin-1, Layilin
Authors:Wegener, K.L., Barsukov, I.L.
Deposit date:2008-01-23
Release date:2008-09-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain
J.Mol.Biol., 382, 2008
2V76
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CRYSTAL STRUCTURE OF THE HUMAN DOK1 PTB DOMAIN
Descriptor:DOCKING PROTEIN 1, TRIETHYLENE GLYCOL, SULFATE ION, ...
Authors:Oxley, C.L., Anthis, N.J., Lowe, E.D., Campbell, I.D., Wegener, K.L.
Deposit date:2007-07-26
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Integrin Phosphorylation Switch: The Effect of {Beta}3 Integrin Tail Phosphorylation on Dok1 and Talin Binding.
J.Biol.Chem., 283, 2008
2H7D
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SOLUTION STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH A CHIMERIC BETA3 INTEGRIN-PIP KINASE PEPTIDE
Descriptor:Talin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2H7E
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SOLUTION STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH A CHIMERIC BETA3 INTEGRIN-PIP KINASE PEPTIDE- MINIMIZED AVERAGE STRUCTURE
Descriptor:Talin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2BRQ
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CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA7 CYTOPLASMIC TAIL PEPTIDE
Descriptor:FILAMIN A, INTEGRIN BETA-7 SUBUNIT, GLUTATHIONE, ...
Authors:Kiema, T.-R., Ylanne, J.
Deposit date:2005-05-11
Release date:2006-02-07
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis of Filamin Binding to Integrins and Competition with Talin.
Mol.Cell, 21, 2006