6CBI

PCNA in complex with inhibitor

Summary for 6CBI

DescriptorProliferating cell nuclear antigen, GLY-ARG-LYS-ARG-ARG-GLN-DAB-SER-MET-THR-GLU-PHE-TYR-HIS, SULFATE ION, ... (4 entities in total)
Functional Keywordspcna, sliding clamp, proliferating cell nuclear antigen, cell cycle
Biological sourceHomo sapiens (Human)
Total number of polymer chains10
Total molecular weight180170.88
Authors
Bruning, J.B.,Wegener, K.L. (deposition date: 2018-02-03, release date: 2018-07-04, Last modification date: 2018-08-29)
Primary citation
Wegener, K.L.,McGrath, A.E.,Dixon, N.E.,Oakley, A.J.,Scanlon, D.B.,Abell, A.D.,Bruning, J.B.
Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24:11325-11331, 2018
PubMed: 29917264 (PDB entries with the same primary citation)
DOI: 10.1002/chem.201801734
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.254111.2%6.8%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cbi
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Molmil generated image of 6cbi
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Molmil generated image of 6cbi
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More Biological unit images

Molmil generated image of 6cbi
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Molmil generated image of 6cbi
rotated about x axis by 90°
Molmil generated image of 6cbi
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6cbi.pdb1.gz [124.41 KB])
Coordinate files for Biological unit (6cbi.pdb2.gz [126.31 KB])
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