Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CBI

PCNA in complex with inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001673	cellular_component	male germ cell nucleus
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005652	cellular_component	nuclear lamina
A	0005654	cellular_component	nucleoplasm
A	0005657	cellular_component	replication fork
A	0005813	cellular_component	centrosome
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006298	biological_process	mismatch repair
A	0006979	biological_process	response to oxidative stress
A	0007507	biological_process	heart development
A	0016604	cellular_component	nuclear body
A	0019899	molecular_function	enzyme binding
A	0019985	biological_process	translesion synthesis
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030855	biological_process	epithelial cell differentiation
A	0030894	cellular_component	replisome
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031297	biological_process	replication fork processing
A	0032077	biological_process	positive regulation of deoxyribonuclease activity
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032355	biological_process	response to estradiol
A	0032405	molecular_function	MutLalpha complex binding
A	0033993	biological_process	response to lipid
A	0034644	biological_process	cellular response to UV
A	0035035	molecular_function	histone acetyltransferase binding
A	0042802	molecular_function	identical protein binding
A	0043596	cellular_component	nuclear replication fork
A	0043626	cellular_component	PCNA complex
A	0044849	biological_process	estrous cycle
A	0044877	molecular_function	protein-containing complex binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0046686	biological_process	response to cadmium ion
A	0070062	cellular_component	extracellular exosome
A	0070182	molecular_function	DNA polymerase binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070557	cellular_component	PCNA-p21 complex
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071548	biological_process	response to dexamethasone
A	0097421	biological_process	liver regeneration
A	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
A	1902065	biological_process	response to L-glutamate
A	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0001673	cellular_component	male germ cell nucleus
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005652	cellular_component	nuclear lamina
B	0005654	cellular_component	nucleoplasm
B	0005657	cellular_component	replication fork
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006272	biological_process	leading strand elongation
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006287	biological_process	base-excision repair, gap-filling
B	0006298	biological_process	mismatch repair
B	0006979	biological_process	response to oxidative stress
B	0007507	biological_process	heart development
B	0016604	cellular_component	nuclear body
B	0019899	molecular_function	enzyme binding
B	0019985	biological_process	translesion synthesis
B	0030331	molecular_function	nuclear estrogen receptor binding
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0030855	biological_process	epithelial cell differentiation
B	0030894	cellular_component	replisome
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031297	biological_process	replication fork processing
B	0032077	biological_process	positive regulation of deoxyribonuclease activity
B	0032139	molecular_function	dinucleotide insertion or deletion binding
B	0032355	biological_process	response to estradiol
B	0032405	molecular_function	MutLalpha complex binding
B	0033993	biological_process	response to lipid
B	0034644	biological_process	cellular response to UV
B	0035035	molecular_function	histone acetyltransferase binding
B	0042802	molecular_function	identical protein binding
B	0043596	cellular_component	nuclear replication fork
B	0043626	cellular_component	PCNA complex
B	0044849	biological_process	estrous cycle
B	0044877	molecular_function	protein-containing complex binding
B	0045739	biological_process	positive regulation of DNA repair
B	0045740	biological_process	positive regulation of DNA replication
B	0046686	biological_process	response to cadmium ion
B	0070062	cellular_component	extracellular exosome
B	0070182	molecular_function	DNA polymerase binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070557	cellular_component	PCNA-p21 complex
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071548	biological_process	response to dexamethasone
B	0097421	biological_process	liver regeneration
B	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
B	1902065	biological_process	response to L-glutamate
B	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
C	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0001673	cellular_component	male germ cell nucleus
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005652	cellular_component	nuclear lamina
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005813	cellular_component	centrosome
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006275	biological_process	regulation of DNA replication
C	0006281	biological_process	DNA repair
C	0006287	biological_process	base-excision repair, gap-filling
C	0006298	biological_process	mismatch repair
C	0006979	biological_process	response to oxidative stress
C	0007507	biological_process	heart development
C	0016604	cellular_component	nuclear body
C	0019899	molecular_function	enzyme binding
C	0019985	biological_process	translesion synthesis
C	0030331	molecular_function	nuclear estrogen receptor binding
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0030855	biological_process	epithelial cell differentiation
C	0030894	cellular_component	replisome
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031297	biological_process	replication fork processing
C	0032077	biological_process	positive regulation of deoxyribonuclease activity
C	0032139	molecular_function	dinucleotide insertion or deletion binding
C	0032355	biological_process	response to estradiol
C	0032405	molecular_function	MutLalpha complex binding
C	0033993	biological_process	response to lipid
C	0034644	biological_process	cellular response to UV
C	0035035	molecular_function	histone acetyltransferase binding
C	0042802	molecular_function	identical protein binding
C	0043596	cellular_component	nuclear replication fork
C	0043626	cellular_component	PCNA complex
C	0044849	biological_process	estrous cycle
C	0044877	molecular_function	protein-containing complex binding
C	0045739	biological_process	positive regulation of DNA repair
C	0045740	biological_process	positive regulation of DNA replication
C	0046686	biological_process	response to cadmium ion
C	0070062	cellular_component	extracellular exosome
C	0070182	molecular_function	DNA polymerase binding
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070557	cellular_component	PCNA-p21 complex
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071548	biological_process	response to dexamethasone
C	0097421	biological_process	liver regeneration
C	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
C	1902065	biological_process	response to L-glutamate
C	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
D	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0001673	cellular_component	male germ cell nucleus
D	0003677	molecular_function	DNA binding
D	0003682	molecular_function	chromatin binding
D	0003684	molecular_function	damaged DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005652	cellular_component	nuclear lamina
D	0005654	cellular_component	nucleoplasm
D	0005657	cellular_component	replication fork
D	0005813	cellular_component	centrosome
D	0006260	biological_process	DNA replication
D	0006272	biological_process	leading strand elongation
D	0006275	biological_process	regulation of DNA replication
D	0006281	biological_process	DNA repair
D	0006287	biological_process	base-excision repair, gap-filling
D	0006298	biological_process	mismatch repair
D	0006979	biological_process	response to oxidative stress
D	0007507	biological_process	heart development
D	0016604	cellular_component	nuclear body
D	0019899	molecular_function	enzyme binding
D	0019985	biological_process	translesion synthesis
D	0030331	molecular_function	nuclear estrogen receptor binding
D	0030337	molecular_function	DNA polymerase processivity factor activity
D	0030855	biological_process	epithelial cell differentiation
D	0030894	cellular_component	replisome
D	0030971	molecular_function	receptor tyrosine kinase binding
D	0031297	biological_process	replication fork processing
D	0032077	biological_process	positive regulation of deoxyribonuclease activity
D	0032139	molecular_function	dinucleotide insertion or deletion binding
D	0032355	biological_process	response to estradiol
D	0032405	molecular_function	MutLalpha complex binding
D	0033993	biological_process	response to lipid
D	0034644	biological_process	cellular response to UV
D	0035035	molecular_function	histone acetyltransferase binding
D	0042802	molecular_function	identical protein binding
D	0043596	cellular_component	nuclear replication fork
D	0043626	cellular_component	PCNA complex
D	0044849	biological_process	estrous cycle
D	0044877	molecular_function	protein-containing complex binding
D	0045739	biological_process	positive regulation of DNA repair
D	0045740	biological_process	positive regulation of DNA replication
D	0046686	biological_process	response to cadmium ion
D	0070062	cellular_component	extracellular exosome
D	0070182	molecular_function	DNA polymerase binding
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0070557	cellular_component	PCNA-p21 complex
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071548	biological_process	response to dexamethasone
D	0097421	biological_process	liver regeneration
D	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
D	1902065	biological_process	response to L-glutamate
D	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
E	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0001673	cellular_component	male germ cell nucleus
E	0003677	molecular_function	DNA binding
E	0003682	molecular_function	chromatin binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005652	cellular_component	nuclear lamina
E	0005654	cellular_component	nucleoplasm
E	0005657	cellular_component	replication fork
E	0005813	cellular_component	centrosome
E	0006260	biological_process	DNA replication
E	0006272	biological_process	leading strand elongation
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006287	biological_process	base-excision repair, gap-filling
E	0006298	biological_process	mismatch repair
E	0006979	biological_process	response to oxidative stress
E	0007507	biological_process	heart development
E	0016604	cellular_component	nuclear body
E	0019899	molecular_function	enzyme binding
E	0019985	biological_process	translesion synthesis
E	0030331	molecular_function	nuclear estrogen receptor binding
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0030855	biological_process	epithelial cell differentiation
E	0030894	cellular_component	replisome
E	0030971	molecular_function	receptor tyrosine kinase binding
E	0031297	biological_process	replication fork processing
E	0032077	biological_process	positive regulation of deoxyribonuclease activity
E	0032139	molecular_function	dinucleotide insertion or deletion binding
E	0032355	biological_process	response to estradiol
E	0032405	molecular_function	MutLalpha complex binding
E	0033993	biological_process	response to lipid
E	0034644	biological_process	cellular response to UV
E	0035035	molecular_function	histone acetyltransferase binding
E	0042802	molecular_function	identical protein binding
E	0043596	cellular_component	nuclear replication fork
E	0043626	cellular_component	PCNA complex
E	0044849	biological_process	estrous cycle
E	0044877	molecular_function	protein-containing complex binding
E	0045739	biological_process	positive regulation of DNA repair
E	0045740	biological_process	positive regulation of DNA replication
E	0046686	biological_process	response to cadmium ion
E	0070062	cellular_component	extracellular exosome
E	0070182	molecular_function	DNA polymerase binding
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0070557	cellular_component	PCNA-p21 complex
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0071548	biological_process	response to dexamethasone
E	0097421	biological_process	liver regeneration
E	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
E	1902065	biological_process	response to L-glutamate
E	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
F	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0001673	cellular_component	male germ cell nucleus
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003684	molecular_function	damaged DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005652	cellular_component	nuclear lamina
F	0005654	cellular_component	nucleoplasm
F	0005657	cellular_component	replication fork
F	0005813	cellular_component	centrosome
F	0006260	biological_process	DNA replication
F	0006272	biological_process	leading strand elongation
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006287	biological_process	base-excision repair, gap-filling
F	0006298	biological_process	mismatch repair
F	0006979	biological_process	response to oxidative stress
F	0007507	biological_process	heart development
F	0016604	cellular_component	nuclear body
F	0019899	molecular_function	enzyme binding
F	0019985	biological_process	translesion synthesis
F	0030331	molecular_function	nuclear estrogen receptor binding
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0030855	biological_process	epithelial cell differentiation
F	0030894	cellular_component	replisome
F	0030971	molecular_function	receptor tyrosine kinase binding
F	0031297	biological_process	replication fork processing
F	0032077	biological_process	positive regulation of deoxyribonuclease activity
F	0032139	molecular_function	dinucleotide insertion or deletion binding
F	0032355	biological_process	response to estradiol
F	0032405	molecular_function	MutLalpha complex binding
F	0033993	biological_process	response to lipid
F	0034644	biological_process	cellular response to UV
F	0035035	molecular_function	histone acetyltransferase binding
F	0042802	molecular_function	identical protein binding
F	0043596	cellular_component	nuclear replication fork
F	0043626	cellular_component	PCNA complex
F	0044849	biological_process	estrous cycle
F	0044877	molecular_function	protein-containing complex binding
F	0045739	biological_process	positive regulation of DNA repair
F	0045740	biological_process	positive regulation of DNA replication
F	0046686	biological_process	response to cadmium ion
F	0070062	cellular_component	extracellular exosome
F	0070182	molecular_function	DNA polymerase binding
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0070557	cellular_component	PCNA-p21 complex
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0071548	biological_process	response to dexamethasone
F	0097421	biological_process	liver regeneration
F	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
F	1902065	biological_process	response to L-glutamate
F	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 B 301

Chain	Residue
B	MET40
B	LEU47
B	PRO234

site_id	AC2
Number of Residues	1
Details	binding site for residue SO4 D 301

Chain	Residue
D	SER42

site_id	AC3
Number of Residues	10
Details	binding site for Di-peptide GLN H 144 and DAB H 145

Chain	Residue
C	HOH315
H	ARG143
H	SER146
H	GLU149
H	PHE150
B	GLU174
C	VAL45
C	ALA252
C	PRO253
C	LYS254

site_id	AC4
Number of Residues	8
Details	binding site for Di-peptide DAB H 145 and SER H 146

Chain	Residue
C	HIS44
C	ALA252
C	PRO253
H	GLN144
H	MET147
H	THR148
H	GLU149
H	PHE150

site_id	AC5
Number of Residues	8
Details	binding site for Di-peptide DAB H 145 and GLU H 149

Chain	Residue
C	ALA252
C	PRO253
H	GLN144
H	SER146
H	MET147
H	THR148
H	PHE150
H	HIS152

site_id	AC6
Number of Residues	8
Details	binding site for Di-peptide GLN I 144 and DAB I 145

Chain	Residue
A	VAL45
A	ALA252
A	PRO253
A	LYS254
A	GLU256
I	SER146
I	GLU149
I	PHE150

site_id	AC7
Number of Residues	8
Details	binding site for Di-peptide DAB I 145 and SER I 146

Chain	Residue
A	HIS44
A	ALA252
A	PRO253
I	GLN144
I	MET147
I	THR148
I	GLU149
I	PHE150

site_id	AC8
Number of Residues	7
Details	binding site for Di-peptide DAB I 145 and GLU I 149

Chain	Residue
A	ALA252
A	PRO253
I	GLN144
I	SER146
I	MET147
I	THR148
I	PHE150

site_id	AC9
Number of Residues	8
Details	binding site for Di-peptide GLN J 144 and DAB J 145

Chain	Residue
D	VAL45
D	ALA252
D	PRO253
D	LYS254
J	ARG143
J	SER146
J	GLU149
J	PHE150

site_id	AD1
Number of Residues	7
Details	binding site for Di-peptide DAB J 145 and GLU J 149

Chain	Residue
D	ALA252
D	PRO253
J	GLN144
J	SER146
J	MET147
J	THR148
J	PHE150

site_id	AD2
Number of Residues	8
Details	binding site for Di-peptide DAB J 145 and SER J 146

Chain	Residue
D	HIS44
D	ALA252
D	PRO253
J	GLN144
J	MET147
J	THR148
J	GLU149
J	PHE150

site_id	AD3
Number of Residues	9
Details	binding site for Di-peptide GLN K 144 and DAB K 145

Chain	Residue
E	VAL45
E	ALA252
E	PRO253
F	GLU174
K	ARG143
K	SER146
K	GLU149
K	PHE150
K	HOH201

site_id	AD4
Number of Residues	8
Details	binding site for Di-peptide DAB K 145 and GLU K 149

Chain	Residue
E	ALA252
E	PRO253
K	GLN144
K	SER146
K	MET147
K	THR148
K	PHE150
K	HIS152

site_id	AD5
Number of Residues	9
Details	binding site for Di-peptide DAB K 145 and SER K 146

Chain	Residue
K	GLU149
K	PHE150
K	HOH202
E	HIS44
E	ALA252
E	PRO253
K	GLN144
K	MET147
K	THR148

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
A	ARG61-LEU79

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
A	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269\|PubMed:10753973, ECO:0000269\|PubMed:11463845, ECO:0000269\|PubMed:12431783, ECO:0000269\|PubMed:16982699, ECO:0000269\|PubMed:20307683

Chain	Residue	Details
H	DAB145
I	DAB145
J	DAB145
K	DAB145
D	ARG61-LYS80
F	ARG61-LYS80

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC and NUAK1 => ECO:0000269\|PubMed:10753973, ECO:0000269\|PubMed:25329316

Chain	Residue	Details
H	SER146
I	SER146
J	SER146
K	SER146
D	LYS14
F	LYS14

site_id	SWS_FT_FI3
Number of Residues	18
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS77
B	LYS77
B	LYS80
B	LYS248
D	LYS77
D	LYS80
D	LYS248
F	LYS77
F	LYS80
F	LYS248
A	LYS80
A	LYS248
C	LYS77
C	LYS80
C	LYS248
E	LYS77
E	LYS80
E	LYS248

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphotyrosine; by EGFR => ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:38459011

Chain	Residue	Details
A	TYR211
C	TYR211
E	TYR211
B	TYR211
D	TYR211
F	TYR211

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269\|PubMed:17108083, ECO:0000269\|PubMed:17130289

Chain	Residue	Details
A	LYS164
C	LYS164
E	LYS164
B	LYS164
D	LYS164
F	LYS164

site_id	SWS_FT_FI6
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
D	LYS254
F	LYS254
A	LYS254
C	LYS254
E	LYS254
B	LYS254

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)