Author results

6A4X
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OXIDASE CHAP-H2
Descriptor:Bleomycin resistance protein, FE (II) ION
Authors:Zhang, B., Wang, Y.S., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
1JR6
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SOLUTION STRUCTURE OF AN ENGINEERED ARGININE-RICH SUBDOMAIN 2 OF THE HEPATITIS C VIRUS NS3 RNA HELICASE
Descriptor:Helicase NS3
Authors:Liu, D., Wyss, D.F., Wang, Y.S., Gesell, J.J.
Deposit date:2001-08-10
Release date:2002-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase.
J.Mol.Biol., 314, 2001
1ONB
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SOLUTION STRUCTURE OF AN ENGINEERED ARGININE-RICH SUBDOMAIN 2 OF THE HEPATITIS C VIRUS NS3 RNA HELICASE
Descriptor:helicase NS3
Authors:Liu, D., Wang, Y.S., Gesell, J.J., Wyss, D.F.
Deposit date:2003-02-27
Release date:2003-03-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase
J.Mol.Biol., 314, 2001
1OVQ
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SOLUTION STRUCTURE OF THE HYPOTHETICAL PROTEIN YQGF FROM ESCHERICHIA COLI
Descriptor:Hypothetical protein yqgF
Authors:Liu, D., Wang, Y.S., Wyss, D.F.
Deposit date:2003-03-27
Release date:2003-11-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the hypothetical protein YqgF from Escherichia coli reveals an RNAse H fold.
J.Biomol.NMR, 27, 2003
4ZIB
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF PYLRS MUTANT BOUND WITH 3-BENZOTHIENYL-L-ALANINE AND ATP
Descriptor:Pyrrolysine--tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Nakamura, A., Guo, L.T., Wang, Y.S., Soll, D.
Deposit date:2015-04-28
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog.
Nucleic Acids Res., 43, 2015
3KMX
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STRUCTURE OF BACE BOUND TO SCH346572
Descriptor:Beta-secretase 1, 4-butoxy-3-chlorobenzyl imidothiocarbamate
Authors:Strickland, C., Wang, Y.
Deposit date:2009-11-11
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
3KMY
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STRUCTURE OF BACE BOUND TO SCH12472
Descriptor:Beta-secretase 1, 3-[2-(3-chlorophenyl)ethyl]pyridin-2-amine
Authors:Strickland, C., Wang, Y.
Deposit date:2009-11-11
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
3KN0
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STRUCTURE OF BACE BOUND TO SCH708236
Descriptor:Beta-secretase 1, 3-[2-(3-{[(furan-2-ylmethyl)(methyl)amino]methyl}phenyl)ethyl]pyridin-2-amine, L(+)-TARTARIC ACID
Authors:Strickland, C., Wang, Y.
Deposit date:2009-11-11
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
6A4Z
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OXIDASE CHAP
Descriptor:ChaP protein, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A52
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OXIDASE CHAP-H1
Descriptor:dioxidase ChaP-H1, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
1FHS
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THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES
Descriptor:GROWTH FACTOR RECEPTOR BOUND PROTEIN-2
Authors:Senior, M.M., Frederick, A.F., Black, S., Perkins, L.M., Wilson, O., Snow, M.E., Wang, Y.-S.
Deposit date:1997-06-12
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2.
J.Biomol.NMR, 11, 1998
3L58
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STRUCTURE OF BACE BOUND TO SCH589432
Descriptor:Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L59
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STRUCTURE OF BACE BOUND TO SCH710413
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5B
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STRUCTURE OF BACE BOUND TO SCH713601
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z,5R)-3-(3-chlorobenzyl)-2-imino-5-methyl-5-(2-methylpropyl)imidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5C
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STRUCTURE OF BACE BOUND TO SCH723871
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, 1-(4-cyanophenyl)-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5D
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STRUCTURE OF BACE BOUND TO SCH723873
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, 1-butyl-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5E
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STRUCTURE OF BACE BOUND TO SCH736062
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (4S)-1-(4-{[(2Z,4R)-4-(2-cyclohexylethyl)-4-(cyclohexylmethyl)-2-imino-5-oxoimidazolidin-1-yl]methyl}benzyl)-4-propylimidazolidin-2-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5F
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STRUCTURE OF BACE BOUND TO SCH736201
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)-2-imino-3-methylimidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
5VOT
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STRUCTURE OF A PROTEIN COMPLEX
Descriptor:Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Chen, S., Zhao, Y., Wang, Y.S., Shekhar, M., Tajkhorshid, E., Gouaux, E.
Deposit date:2017-05-03
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Cell, 170, 2017
5VOU
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STRUCTURE OF A PROTEIN COMPLEX
Descriptor:Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Chen, S., Zhao, Y., Wang, Y.S., Shekhar, M., Tajkhorshid, E., Gouaux, E.
Deposit date:2017-05-03
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Cell, 170, 2017
5VOV
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STRUCTURE OF A PROTEIN COMPLEX
Descriptor:Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Zhao, Y., Chen, S., Wang, Y.S., Shekhar, M., Tajkhorshid, E., Gouaux, E.
Deposit date:2017-05-03
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Cell, 170, 2017
4N9F
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CRYSTAL STRUCTURE OF THE VIF-CBFBETA-CUL5-ELOB-ELOC PENTAMERIC COMPLEX
Descriptor:Cullin-5, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ...
Authors:Guo, Y.Y., Dong, L.Y., Huang, Z.W.
Deposit date:2013-10-21
Release date:2014-01-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif
Nature, 505, 2014
4Q6G
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF ACKRS-1 BOUND WITH N-ACETYL-LYSINE AND ADPNP
Descriptor:Pyrrolysine--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1,2-ETHANEDIOL, ...
Authors:Eiler, D.R., Kavran, J., Steitz, T.A.
Deposit date:2014-04-22
Release date:2014-11-12
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TQD
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF IFRS BOUND WITH 3-IODO-L-PHE AND ATP
Descriptor:Pyrrolysine--tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Nakamura, A., O'Donoghue, P., Soll, D.
Deposit date:2014-06-11
Release date:2014-11-12
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.1429 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TQF
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF IFRS BOUND WITH 2-(5-BROMOTHIENYL)-L-ALA AND ATP
Descriptor:Pyrrolysine--tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Nakamura, A., O'Donoghue, P., Soll, D.
Deposit date:2014-06-11
Release date:2014-11-12
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.7143 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
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