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2NXW
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BU of 2nxw by Molmil
Crystal structure of phenylpyruvate decarboxylase of Azospirillum brasilense
Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Versees, W, Spaepen, S, Vanderleyden, J, Steyaert, J.
Deposit date:2006-11-20
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.
Febs J., 274, 2007
1KIC
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BU of 1kic by Molmil
Inosine-adenosine-guanosine preferring nucleoside hydrolase from Trypanosoma vivax: Asp10Ala mutant in complex with inosine
Descriptor: CALCIUM ION, INOSINE, NICKEL (II) ION, ...
Authors:Versees, W, Decanniere, K, Van Holsbeke, E, Devroede, N, Steyaert, J.
Deposit date:2001-12-03
Release date:2002-05-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.
J.Biol.Chem., 277, 2002
1KIE
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BU of 1kie by Molmil
Inosine-adenosine-guanosine preferring nucleoside hydrolase from Trypanosoma vivax: Asp10Ala mutant in complex with 3-deaza-adenosine
Descriptor: 3-DEAZA-ADENOSINE, CALCIUM ION, NICKEL (II) ION, ...
Authors:Versees, W, Decanniere, K, Van Holsbeke, E, Devroede, N, Steyaert, J.
Deposit date:2001-12-03
Release date:2002-05-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.
J.Biol.Chem., 277, 2002
1HOZ
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BU of 1hoz by Molmil
CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX
Descriptor: CALCIUM ION, GLYCEROL, INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE
Authors:Versees, W, Decanniere, K, Pelle, R, Depoorter, J, Parkin, D.W, Steyaert, J.
Deposit date:2000-12-12
Release date:2001-12-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
J.Mol.Biol., 307, 2001
1HP0
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BU of 1hp0 by Molmil
CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE
Descriptor: 3-DEAZA-ADENOSINE, CALCIUM ION, INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE
Authors:Versees, W, Decanniere, K, Pelle, R, Depoorter, J, Parkin, D.W, Steyaert, J.
Deposit date:2000-12-12
Release date:2001-12-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
J.Mol.Biol., 307, 2001
1R4F
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BU of 1r4f by Molmil
Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma vivax: Trp260Ala Mutant In Complex With 3-Deaza-Adenosine
Descriptor: 3-DEAZA-ADENOSINE, CALCIUM ION, IAG-nucleoside hydrolase
Authors:Versees, W, Loverix, S, Vandemeulebroucke, A, Geerlings, P, Steyaert, J.
Deposit date:2003-10-06
Release date:2004-04-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leaving group activation by aromatic stacking: an alternative to general Acid catalysis.
J.Mol.Biol., 338, 2004
2FF1
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BU of 2ff1 by Molmil
Crystal structure of Trypanosoma vivax nucleoside hydrolase soaked with ImmucillinH
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase
Authors:Versees, W, Barlow, J, Steyaert, J.
Deposit date:2005-12-18
Release date:2006-05-23
Last modified:2022-10-05
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T.vivax: Enzyme Conformational Changes and Implications for Catalysis.
J.Mol.Biol., 359, 2006
2FF2
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BU of 2ff2 by Molmil
Crystal structure of Trypanosoma vivax nucleoside hydrolase co-crystallized with ImmucillinH
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase, ...
Authors:Versees, W, Barlow, J, Steyaert, J.
Deposit date:2005-12-18
Release date:2006-05-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T.vivax: Enzyme Conformational Changes and Implications for Catalysis.
J.Mol.Biol., 359, 2006
2Q5Q
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BU of 2q5q by Molmil
X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP and 5-phenyl-2-oxo-valeric acid
Descriptor: 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, 5-PHENYL-2-KETO-VALERIC ACID, GLYCEROL, ...
Authors:Versees, W, Spaepen, S, Wood, M.D, Leeper, F.J, Vanderleyden, J, Steyaert, J.
Deposit date:2007-06-01
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.
J.Biol.Chem., 282, 2007
2Q5L
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BU of 2q5l by Molmil
X-ray structure of phenylpyruvate decarboxylase in complex with 2-(1-hydroxyethyl)-3-deaza-ThDP
Descriptor: 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1R)-1-HYDROXYETHYL]-3-METHYL-2-THIENYL}ETHYL TRIHYDROGEN DIPHOSPHATE, 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1S)-1-HYDROXYETHYL]-3-METHYL-2-THIENYL}ETHYL TRIHYDROGEN DIPHOSPHATE, CHLORIDE ION, ...
Authors:Versees, W, Spaepen, S, Wood, M.D, Leeper, F.J, Vanderleyden, J, Steyaert, J.
Deposit date:2007-06-01
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.
J.Biol.Chem., 282, 2007
2Q5J
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BU of 2q5j by Molmil
X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP
Descriptor: 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, Phenylpyruvate decarboxylase
Authors:Versees, W, Spaepen, S, Wood, M.D, Leeper, F.J, Vanderleyden, J, Steyaert, J.
Deposit date:2007-06-01
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.
J.Biol.Chem., 282, 2007
2Q5O
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BU of 2q5o by Molmil
X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP and phenylpyruvate
Descriptor: 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, 3-PHENYLPYRUVIC ACID, GLYCEROL, ...
Authors:Versees, W, Spaepen, S, Wood, M.D, Leeper, F.J, Vanderleyden, J, Steyaert, J.
Deposit date:2007-06-01
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.
J.Biol.Chem., 282, 2007
3EPX
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BU of 3epx by Molmil
Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol
Descriptor: (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidine-3,4-diol, CALCIUM ION, GLYCEROL, ...
Authors:Versees, W, Goeminne, A, Berg, M, Vandemeulebroucke, A, Haemers, A, Augustyns, K, Steyaert, J.
Deposit date:2008-09-30
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
Biochim.Biophys.Acta, 1794, 2009
3EPW
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BU of 3epw by Molmil
Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
Descriptor: 7-(((2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, CALCIUM ION, IAG-nucleoside hydrolase, ...
Authors:Versees, W, Goeminne, A, Berg, M, Vandemeulebroucke, A, Haemers, A, Augustyns, K, Steyaert, J.
Deposit date:2008-09-30
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
Biochim.Biophys.Acta, 1794, 2009
5MJ7
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BU of 5mj7 by Molmil
Structure of the C. elegans nucleoside hydrolase
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Uncharacterized protein
Authors:Versees, W, Singh, R.K.
Deposit date:2016-11-30
Release date:2017-03-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.
Protein Sci., 26, 2017
3B9G
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BU of 3b9g by Molmil
Crystal structure of loop deletion mutant of Trypanosoma vivax nucleoside hydrolase (3GTvNH) in complex with ImmH
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase, ...
Authors:Vandemeulebroucke, A, De Vos, S, Van Holsbeke, E, Steyaert, J, Versees, W.
Deposit date:2007-11-05
Release date:2008-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Flexible Loop as a Functional Element in the Catalytic Mechanism of Nucleoside Hydrolase from Trypanosoma vivax.
J.Biol.Chem., 283, 2008
5HJN
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BU of 5hjn by Molmil
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster
Descriptor: LD10117p, SULFATE ION
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2016-01-13
Release date:2016-09-21
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat.Struct.Mol.Biol., 23, 2016
7A0V
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BU of 7a0v by Molmil
Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody
Descriptor: GLYCEROL, MAGNESIUM ION, Nanobody 13015, ...
Authors:Paesmans, J, Galicia, C, Martin, E, Versees, W.
Deposit date:2020-08-11
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.
Elife, 9, 2020
7A17
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BU of 7a17 by Molmil
Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, GLYCEROL, Isoform 2 of Synaptojanin-1, ...
Authors:Paesmans, J, Galicia, C, Martin, E, Versees, W.
Deposit date:2020-08-12
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.
Elife, 9, 2020
3TMA
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BU of 3tma by Molmil
Crystal structure of TrmN from Thermus thermophilus
Descriptor: PHOSPHATE ION, methyltransferase
Authors:Fislage, M, Roovers, M, Tuszynska, I, Bujnicki, J.M, Droogmans, L, Versees, W.
Deposit date:2011-08-31
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life.
Nucleic Acids Res., 40, 2012
5HJQ
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BU of 5hjq by Molmil
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, LD10117p
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2016-01-13
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat.Struct.Mol.Biol., 23, 2016
6HLU
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BU of 6hlu by Molmil
Crystal structure of the LRR-Roc-COR domain of the Chlorobium tepidum Roco protein
Descriptor: Rab family protein
Authors:Deyaert, E, Versees, W, Singh, R.
Deposit date:2018-09-11
Release date:2018-12-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structure and nucleotide-induced conformational dynamics of theChlorobium tepidumRoco protein.
Biochem. J., 476, 2019
6R82
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BU of 6r82 by Molmil
Crystal structure of the TLDc domain of Skywalker/TBC1D24 from Drosophila melanogaster
Descriptor: GTPase-activating protein skywalker
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2019-03-30
Release date:2019-07-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.046 Å)
Cite:TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model.
Brain, 142, 2019
5M04
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BU of 5m04 by Molmil
Structure of ObgE from Escherichia coli
Descriptor: GTPase ObgE/CgtA, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Gkekas, S, Singh, R.K, Versees, W.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and biochemical analysis of Escherichia coli ObgE, a central regulator of bacterial persistence.
J. Biol. Chem., 292, 2017
5MI8
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BU of 5mi8 by Molmil
Structure of the phosphomimetic mutant of EF-Tu T383E
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A.
Deposit date:2016-11-27
Release date:2017-12-20
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Sci Adv, 4, 2018

 

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