Author results

1II6
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CRYSTAL STRUCTURE OF THE MITOTIC KINESIN EG5 IN COMPLEX WITH MG-ADP.
Descriptor:KINESIN-RELATED MOTOR PROTEIN Eg5, NITRATE ION, MAGNESIUM ION, ...
Authors:Turner, J., Anderson, R., Guo, J., Beraud, C., Sakowicz, R., Fletterick, R.
Deposit date:2001-04-20
Release date:2001-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
J.Biol.Chem., 276, 2001
1CZD
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CRYSTAL STRUCTURE OF THE PROCESSIVITY CLAMP GP45 FROM BACTERIOPHAGE T4
Descriptor:DNA POLYMERASE ACCESSORY PROTEIN G45
Authors:Moarefi, I., Jeruzalmi, D., Turner, J., O'Donnell, M., Kuriyan, J.
Deposit date:1999-09-02
Release date:2000-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage.
J.Mol.Biol., 296, 2000
2W3L
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CRYSTAL STRUCTURE OF CHIMAERIC BCL2-XL AND PHENYL TETRAHYDROISOQUINOLINE AMIDE COMPLEX
Descriptor:APOPTOSIS REGULATOR BCL-2, 1-(2-{[(3S)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide
Authors:Porter, J., Payne, A., de Candole, B., Ford, D., Hutchinson, B., Trevitt, G., Turner, J., Edwards, C., Watkins, C., Whitcombe, I., Davis, J., Stubberfield, C., Fisher, M., Lamers, M.
Deposit date:2008-11-13
Release date:2008-12-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
1RY6
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CRYSTAL STRUCTURE OF INTERNAL KINESIN MOTOR DOMAIN
Descriptor:INTERNAL KINESIN, SULFATE ION
Authors:Shipley, K., Hekmat-Nejad, M., Turner, J., Moores, C., Anderson, R., Milligan, R., Sakowicz, R., Fletterick, R.
Deposit date:2003-12-19
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of a kinesin microtubule depolymerization machine.
Embo J., 23, 2004
2JES
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PORTAL PROTEIN (GP6) FROM BACTERIOPHAGE SPP1
Descriptor:PORTAL PROTEIN, UNIDENTIFIED FRAGMENT OF PORTAL PROTEIN, MERCURY (II) ION, ...
Authors:Lebedev, A.A., Krause, M.H., Isidro, A.L., Vagin, A.A., Orlova, E.V., Turner, J., Dodson, E.J., Tavares, P., Antson, A.A.
Deposit date:2007-01-21
Release date:2007-03-27
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Framework for DNA Translocation Via the Viral Portal Protein
Embo J., 26, 2007
2JJS
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STRUCTURE OF HUMAN CD47 IN COMPLEX WITH HUMAN SIGNAL REGULATORY PROTEIN (SIRP) ALPHA
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, LEUKOCYTE SURFACE ANTIGEN CD47, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hatherley, D., Graham, S.C., Turner, J., Harlos, K., Stuart, D.I., Barclay, A.N.
Deposit date:2008-04-22
Release date:2008-08-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31, 2008
2JJT
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STRUCTURE OF HUMAN CD47 IN COMPLEX WITH HUMAN SIGNAL REGULATORY PROTEIN (SIRP) ALPHA
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, LEUKOCYTE SURFACE ANTIGEN CD47, N-ACETYL-D-GLUCOSAMINE
Authors:Hatherley, D., Graham, S.C., Turner, J., Harlos, K., Stuart, D.I., Barclay, A.N.
Deposit date:2008-04-22
Release date:2008-08-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31, 2008
2JJU
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STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA
Descriptor:SIGNAL REGULATORY PROTEIN BETA-1, CHLORIDE ION, SULFATE ION
Authors:Hatherley, D., Graham, S.C., Turner, J., Harlos, K., Stuart, D.I., Barclay, A.N.
Deposit date:2008-04-22
Release date:2008-08-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
2JJV
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STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA(2)
Descriptor:SIGNAL-REGULATORY PROTEIN BETA 1., SULFATE ION, CHLORIDE ION
Authors:Hatherley, D., Graham, S.C., Turner, J., Harlos, K., Stuart, D.I., Barclay, A.N.
Deposit date:2008-04-22
Release date:2008-08-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
2JJW
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STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) GAMMA
Descriptor:SIGNAL REGULATORY PROTEIN GAMMA
Authors:Hatherley, D., Graham, S.C., Turner, J., Harlos, K., Stuart, D.I., Barclay, A.N.
Deposit date:2008-04-22
Release date:2008-08-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
2VSC
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STRUCTURE OF THE IMMUNOGLOBULIN-SUPERFAMILY ECTODOMAIN OF HUMAN CD47
Descriptor:LEUKOCYTE SURFACE ANTIGEN CD47, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Hatherley, D., Graham, S.C., Turner, J., Harlos, K., Stuart, D.I., Barclay, A.N.
Deposit date:2008-04-22
Release date:2008-08-12
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
5V3E
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CRYSTAL STRUCTURE OF THE SENSOR DOMAIN OF THE TRANSCRIPTIONAL REGULATOR HCPR FROM PORPHYROMONAS GINGIVALIS
Descriptor:Transcriptional regulator, GLYCEROL
Authors:Musayev, F.N., Belvin, B.R., Escalante, C.R., Turner, J., Scarsdale, J.N., Lewis, J.P.
Deposit date:2017-03-07
Release date:2018-06-13
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR.
To be published
6C6M
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IGCAM3 OF HUMAN MLCK1
Descriptor:Myosin light chain kinase, smooth muscle
Authors:Zuccola, H.J., Turner, J.
Deposit date:2018-01-19
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeted disruption of epithelial MLCK1 trafficking: A novel approach to non-enzymatic kinase inhibition and intestinal barrier restoration.
To Be Published
3IGB
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BACE-1 WITH COMPOUND 3
Descriptor:Beta-secretase 1, 8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Authors:Olland, A.M.
Deposit date:2009-07-27
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.238 Å)
Cite:Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors
J.Med.Chem., 52, 2009
3IND
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BACE1 WITH THE AMINOHYDANTOIN COMPOUND 29
Descriptor:Beta-secretase 1, (5S)-2-amino-3-methyl-5-phenyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]-3,5-dihydro-4H-imidazol-4-one
Authors:Olland, A.M., Chopra, R.
Deposit date:2009-08-12
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.246 Å)
Cite:Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
J.Med.Chem., 53, 2010
3INE
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BACE1 WITH THE AMINOHYDANTOIN COMPOUND S-34
Descriptor:Beta-secretase 1, (5S)-2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]-3,5-dihydro-4H-imidazol-4-one
Authors:Olland, A.M., Chopra, R.
Deposit date:2009-08-12
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
J.Med.Chem., 53, 2010
3INF
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BACE1 WITH THE AMINOHYDANTOIN COMPOUND 37
Descriptor:Beta-secretase 1, (5S)-2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-(3-pyridin-3-ylphenyl)-3,5-dihydro-4H-imidazol-4-one
Authors:Olland, A.M., Chopra, R.
Deposit date:2009-08-12
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
J.Med.Chem., 53, 2010
3INH
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BACE1 WITH THE AMINOHYDANTOIN COMPOUND R-58
Descriptor:Beta-secretase 1, (5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Authors:Olland, A.M., Chopra, R.
Deposit date:2009-08-12
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
J.Med.Chem., 53, 2010
3L38
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BACE1 IN COMPLEX WITH THE AMINOPYRIDINE COMPOUND 44
Descriptor:Beta-secretase 1, 6-({2-(2-chlorophenyl)-5-[4-(pyrimidin-5-yloxy)phenyl]-1H-pyrrol-1-yl}methyl)pyridin-2-amine
Authors:Olland, A.M., Chopra, R.
Deposit date:2009-12-16
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3L3A
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BACE-1 WITH THE AMINOPYRIDINE COMPOUND 32
Descriptor:Beta-secretase 1, 4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorophenyl)-1H-pyrrol-2-yl}phenoxy)butanenitrile
Authors:Olland, A.M., Chopra, R.
Deposit date:2009-12-16
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.362 Å)
Cite:Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3S7L
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PYRAZOLYL AND THIENYL AMINOHYDANTOINS AS POTENT BACE1 INHIBITORS
Descriptor:Beta-secretase 1, (5S)-2-amino-5-(1-ethyl-1H-pyrazol-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Authors:Chopra, R., Olland, A., Svenson, K.
Deposit date:2011-05-26
Release date:2011-08-31
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2' region.
Bioorg.Med.Chem.Lett., 21, 2011
3S7M
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PYRAZOLYL AND THIENYL AMINOHYDANTOINS AS POTENT BACE1 INHIBITORS
Descriptor:Beta-secretase 1, (5S)-2-amino-3-methyl-5-[3-(pyridin-3-yl)phenyl]-5-(thiophen-3-yl)-3,5-dihydro-4H-imidazol-4-one
Authors:Chopra, R., Olland, A., Svenson, K.
Deposit date:2011-05-26
Release date:2011-08-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2' region.
Bioorg.Med.Chem.Lett., 21, 2011
4DG6
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CRYSTAL STRUCTURE OF DOMAINS 1 AND 2 OF LRP6
Descriptor:Low-density lipoprotein receptor-related protein 6, N-ACETYL-D-GLUCOSAMINE, PHOSPHATE ION
Authors:Ceska, T.A., Doyle, C., Slocombe, P.
Deposit date:2012-01-25
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Characterization of the interaction of sclerostin with the LRP family of Wnt co-receptors
To be Published
2QU2
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BACE1 WITH COMPOUND 1
Descriptor:Beta-secretase 1, N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
Authors:Chopra, R.
Deposit date:2007-08-03
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2QU3
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BACE1 WITH COMPOUND 2
Descriptor:Beta-secretase 1, N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
Authors:Chopra, R.
Deposit date:2007-08-03
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
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