Summary for 3L38
| Related | 3L3A |
|---|---|
| Descriptor | Beta-secretase 1, 6-({2-(2-chlorophenyl)-5-[4-(pyrimidin-5-yloxy)phenyl]-1H-pyrrol-1-yl}methyl)pyridin-2-amine (3 entities in total) |
| Functional Keywords | beta-secretase, bace-1, aminopyridine, inhibitor, aspartyl protease, disulfide bond, protease, transmembrane, zymogen, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein P56817 |
| Total number of polymer chains | 1 |
| Total molecular weight | 46894.9 |
| Authors | Olland, A.M.,Chopra, R. (deposition date: 2009-12-16, release date: 2010-04-28, Last modification date: 2011-07-13) |
| Primary citation | Malamas, M.S.,Barnes, K.,Hui, Y.,Johnson, M.,Lovering, F.,Condon, J.,Fobare, W.,Solvibile, W.,Turner, J.,Hu, Y.,Manas, E.S.,Fan, K.,Olland, A.,Chopra, R.,Bard, J.,Pangalos, M.N.,Reinhart, P.,Robichaud, A.J. Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Bioorg.Med.Chem.Lett., 20:2068-2073, 2010 PubMed: 20223661 (PDB entries with the same primary citation) DOI: 10.1016/j.bmcl.2010.02.075  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
| NMR Information |
