7P00
| Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | Deposit date: | 2021-06-29 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7P02
| Human Neurokinin 1 receptor (NK1R) substance P Gs complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | Deposit date: | 2021-06-29 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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3BWD
| Crystal structure of the plant Rho protein ROP5 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rac-like GTP-binding protein ARAC6 | Authors: | Thomas, C, Berken, A. | Deposit date: | 2008-01-09 | Release date: | 2008-03-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Crystal structure of the plant Rho protein ROP5 To be Published
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2NTX
| Prone8 | Descriptor: | Emb|CAB41934.1 | Authors: | Thomas, C, Fricke, I, Scrima, A, Berken, A, Wittinghofer, A. | Deposit date: | 2006-11-08 | Release date: | 2007-01-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions Mol.Cell, 25, 2007
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2NTY
| Rop4-GDP-PRONE8 | Descriptor: | Emb|CAB41934.1, GUANOSINE-5'-DIPHOSPHATE, Rac-like GTP-binding protein ARAC5 | Authors: | Thomas, C, Fricke, I, Scrima, A, Berken, A, Wittinghofer, A. | Deposit date: | 2006-11-08 | Release date: | 2007-01-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions Mol.Cell, 25, 2007
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2WBL
| Three-dimensional structure of a binary ROP-PRONE complex | Descriptor: | RAC-LIKE GTP-BINDING PROTEIN ARAC2, RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8 | Authors: | Thomas, C, Fricke, I, Weyand, M, Berken, A. | Deposit date: | 2009-03-02 | Release date: | 2009-04-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | 3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction. Biol.Chem., 390, 2009
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3S9D
| binary complex between IFNa2 and IFNAR2 | Descriptor: | CHLORIDE ION, Interferon alpha-2, Interferon alpha/beta receptor 2 | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-01 | Release date: | 2011-08-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9999 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3SE3
| human IFNa2-IFNAR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha 2b, Interferon alpha/beta receptor 1, ... | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-10 | Release date: | 2011-08-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (4.0001 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3S98
| human IFNAR1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha/beta receptor 1 | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-01 | Release date: | 2011-08-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3S8W
| D2 domain of human IFNAR2 | Descriptor: | CHLORIDE ION, Interferon alpha/beta receptor 2 | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-05-31 | Release date: | 2011-08-31 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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3SE4
| human IFNw-IFNAR ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2, ... | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2011-06-10 | Release date: | 2011-08-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.5001 Å) | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
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5OPI
| Crystal structure of the TAPBPR-MHC I peptide editing complex | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... | Authors: | Thomas, C, Tampe, R. | Deposit date: | 2017-08-09 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing. Science, 358, 2017
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4DEP
| Structure of the IL-1b signaling complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... | Authors: | Thomas, C, Garcia, K.C. | Deposit date: | 2012-01-21 | Release date: | 2012-03-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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6RAN
| Heterodimeric ABC exporter TmrAB in inward-facing wide conformation | Descriptor: | Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10 | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAG
| Heterodimeric ABC exporter TmrAB in inward-facing wide conformation under turnover conditions | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAJ
| Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAK
| Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing occluded conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAI
| Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing occluded conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding and permease protein, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAH
| Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding and permease protein, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAM
| Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation with wider opened intracellular gate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAF
| Heterodimeric ABC exporter TmrAB in inward-facing narrow conformation under turnover conditions | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Anti-vesicular stomatitis virus N VHH, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6RAL
| Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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7QVM
| Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex | Descriptor: | Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Waltenspuhl, Y, Ehrenmann, J, Vacca, S, Thom, C, Medalia, O, Pluckthun, A. | Deposit date: | 2022-01-21 | Release date: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nat Commun, 13, 2022
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5OGI
| Complex of a binding protein and human adenovirus C 5 hexon | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | Deposit date: | 2017-07-13 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
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6EQC
| Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon | Descriptor: | Hexon protein, scFv of 9C12 antibody | Authors: | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | Deposit date: | 2017-10-12 | Release date: | 2018-02-07 | Last modified: | 2018-02-14 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
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