Author results

2EAR
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P21 CRYSTAL OF THE SR CA2+-ATPASE WITH BOUND TG
Descriptor:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ...
Authors:Takahashi, M., Kondou, Y., Toyoshima, C.
Deposit date:2007-02-02
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2EAT
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CRYSTAL STRUCTURE OF THE SR CA2+-ATPASE WITH BOUND CPA AND TG
Descriptor:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ...
Authors:Takahashi, M., Kondou, Y., Toyoshima, C.
Deposit date:2007-02-02
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2EAU
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CRYSTAL STRUCTURE OF THE SR CA2+-ATPASE WITH BOUND CPA IN THE PRESENCE OF CURCUMIN
Descriptor:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, PHOSPHATIDYLETHANOLAMINE
Authors:Takahashi, M., Kondou, Y., Toyoshima, C.
Deposit date:2007-02-02
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2YSO
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SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGER (REGION 656-688) OF HUMAN ZINC FINGER PROTEIN 95 HOMOLOG
Descriptor:Zinc finger protein 95 homolog, ZINC ION
Authors:Takahashi, M., Kuwasako, K., Tsuda, K., Tanabe, W., Harada, T., Watanabe, S., Tochio, N., Muto, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-03
Release date:2007-10-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the C2H2 type zinc finger (region 656-688) of human Zinc finger protein 95 homolog
To be Published
2YSP
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SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGER (REGION 507-539) OF HUMAN ZINC FINGER PROTEIN 224
Descriptor:Zinc finger protein 224, ZINC ION
Authors:Takahashi, M., Kuwasako, K., Tsuda, K., Tanabe, W., Harada, T., Watanabe, S., Tochio, N., Muto, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-03
Release date:2007-10-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the C2H2 type zinc finger (region 507-539)of human Zinc finger protein 224
To be Published
3W5E
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CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 31E
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide, ZINC ION, ...
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2013-01-28
Release date:2013-05-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Bioorg.Med.Chem.Lett., 23, 2013
3WD9
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CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 10F
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 4-[(4-{2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}phenyl)amino]-2-phenylpyrimidine-5-carboxamide, ZINC ION, ...
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2013-06-11
Release date:2013-10-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Bioorg.Med.Chem., 21, 2013
2MGZ
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SOLUTION STRUCTURE OF RBFOX FAMILY ASD-1 RRM AND SUP-12 RRM IN TERNARY COMPLEX WITH RNA
Descriptor:Protein ASD-1, isoform a, Protein SUP-12, ...
Authors:Takahashi, M., Kuwasako, K., Unzai, S., Tsuda, K., Yoshikawa, S., He, F., Kobayashi, N., Guntert, P., Shirouzu, M., Ito, T., Tanaka, A., Yokoyama, S., Hagiwara, M., Kuroyanagi, H., Muto, Y.
Deposit date:2013-11-12
Release date:2014-08-13
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing
Nat.Struct.Mol.Biol., 21, 2014
2RNE
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SOLUTION STRUCTURE OF THE SECOND RNA RECOGNITION MOTIF (RRM) OF TIA-1
Descriptor:Tia1 protein
Authors:Takahashi, M., Kuwasako, K., Abe, C., Tsuda, K., Inoue, M., Terada, T., Shirouzu, M., Kobayashi, N., Kigawa, T., Taguchi, S., Guntert, P., Hayashizaki, Y., Tanaka, A., Muto, Y., Yokoyama, S.
Deposit date:2007-12-19
Release date:2008-11-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode
Biochemistry, 47, 2008
2RU3
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SOLUTION STRUCTURE OF C.ELEGANS SUP-12 RRM IN COMPLEX WITH RNA
Descriptor:Protein SUP-12, isoform a, RNA (5'-R(*GP*UP*GP*UP*GP*C)-3')
Authors:Takahashi, M., Kuwasako, K., Unzai, S., Tsuda, K., Yoshikawa, S., He, F., Kobayashi, N., Guntert, P., Shirouzu, M., Ito, T., Tanaka, A., Yokoyama, S., Hagiwara, M., Kuroyanagi, H., Muto, Y.
Deposit date:2013-11-12
Release date:2014-08-13
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing
Nat.Struct.Mol.Biol., 21, 2014
3VSW
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HUMAN RENIN IN COMPLEX WITH COMPOUND 8
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-{4-[2-(3-methoxypropoxy)phenyl]-3-oxopiperazin-1-yl}-2-(propan-2-yl)hexanamide
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2012-05-11
Release date:2012-07-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VSX
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HUMAN RENIN IN COMPLEX WITH COMPOUND 18
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-2-(propan-2-yl)hexanamide
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2012-05-11
Release date:2012-07-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VUC
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HUMAN RENIN IN COMPLEX WITH COMPOUND 5
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-[(1R,2S,3S,5S,7S)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]hexanamide
Authors:Takahashi, M., Matsui, Y., Hanzawa, H.
Deposit date:2012-06-26
Release date:2013-05-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor
ACS MED.CHEM.LETT., 3, 2012
3A29
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CRYSTAL STRUCTURE OF HUMAN LIVER FBPASE IN COMPLEX WITH TRICYCLIC INHIBITOR
Descriptor:Fructose-1,6-bisphosphatase 1, 2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate
Authors:Takahashi, M., Sone, J., Hanzawa, H.
Deposit date:2009-05-08
Release date:2009-10-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
3KBZ
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CRYSTAL STRUCTURE OF HUMAN LIVER FBPASE IN COMPLEX WITH TRICYCLIC INHIBITOR 6
Descriptor:Fructose-1,6-bisphosphatase 1, {[(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid
Authors:Takahashi, M., Sone, J., Hanzawa, H.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3KC0
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CRYSTAL STRUCTURE OF HUMAN LIVER FBPASE IN COMPLEX WITH TRICYCLIC INHIBITOR 10B
Descriptor:Fructose-1,6-bisphosphatase 1, [(8H-indeno[1,2-d][1,3]thiazol-4-yloxy)methyl]phosphonic acid
Authors:Takahashi, M., Sone, J., Hanzawa, H.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3KC1
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CRYSTAL STRUCTURE OF HUMAN LIVER FBPASE IN COMPLEX WITH TRICYCLIC INHIBITOR 19A
Descriptor:Fructose-1,6-bisphosphatase 1, {[(7-carbamoyl-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid
Authors:Takahashi, M., Sone, J., Hanzawa, H.
Deposit date:2009-10-20
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3VYD
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HUMAN RENIN IN COMPLEX WITH INHIBITOR 6
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3S,5R)-5-{[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]methyl}-N-(3-methylbutyl)piperidine-3-carboxamide
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VYE
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HUMAN RENIN IN COMPLEX WITH INHIBITOR 7
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(3-methylbutyl)piperidine-3-carboxamide
Authors:Takahashi, M., Matsui, Y., Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VYF
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HUMAN RENIN IN COMPLEX WITH INHIBITOR 9
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(2,6-dimethylheptan-4-yl)piperidine-3-carboxamide
Authors:Takahashi, M., Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
4YCL
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CRYSTAL STRUCTURE OF THE SR CA2+-ATPASE WITH BOUND CPA
Descriptor:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, POTASSIUM ION, MAGNESIUM ION, ...
Authors:Ogawa, H., Takahashi, M., Kondou, Y., Toyoshima, C.
Deposit date:2015-02-20
Release date:2015-04-01
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors
Proc.Natl.Acad.Sci.Usa, 104, 2007
5GVQ
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SOLUTION STRUCTURE OF THE FIRST RRM DOMAIN OF HUMAN SPLICEOSOMAL PROTEIN SF3B49
Descriptor:Splicing factor 3B subunit 4
Authors:Kuwasako, K., Nameki, N., Tsuda, K., Takahashi, M., Sato, A., Tochio, N., Inoue, M., Terada, T., Kigawa, T., Kobayashi, N., Shirouzu, M., Ito, T., Sakamoto, T., Wakamatsu, K., Guntert, P., Takahashi, S., Yokoyama, S., Muto, Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2016-09-06
Release date:2017-04-12
Method:SOLUTION NMR
Cite:Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.
Protein Sci., 26, 2017
2CYA
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CRYSTAL STRUCTURE OF TYROSYL-TRNA SYNTHETASE FROM AEROPYRUM PERNIX
Descriptor:Tyrosyl-tRNA synthetase, SULFATE ION
Authors:Kuratani, M., Sakai, H., Takahashi, M., Yanagisawa, T., Kobayashi, T., Murayama, K., Chen, L., Liu, Z.J., Wang, B.C., Kuroishi, C., Kuramitsu, S., Terada, T., Bessho, Y., Shirouzu, M., Sekine, S.I., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-06
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea
J.Mol.Biol., 355, 2005
2CYB
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CRYSTAL STRUCTURE OF TYROSYL-TRNA SYNTHETASE COMPLEXED WITH L-TYROSINE FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Tyrosyl-tRNA synthetase, TYROSINE
Authors:Kuratani, M., Sakai, H., Takahashi, M., Yanagisawa, T., Kobayashi, T., Terada, T., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-06
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea
J.Mol.Biol., 355, 2006
2CYC
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CRYSTAL STRUCTURE OF TYROSYL-TRNA SYNTHETASE COMPLEXED WITH L-TYROSINE FROM PYROCOCCUS HORIKOSHII
Descriptor:tyrosyl-tRNA synthetase, TYROSINE
Authors:Kuratani, M., Sakai, H., Takahashi, M., Yanagisawa, T., Kobayashi, T., Sakamoto, K., Terada, T., Shirouzu, M., Sekine, S., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-06
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea
J.Mol.Biol., 355, 2006