6J6Y

FGFR4 D2 - Fab complex

Summary for 6J6Y

• Entry DOI: 10.2210/pdb6j6y/pdb
• Descriptor: Fibroblast growth factor receptor 4, Fab Heavy chain, Fab light chain, ... (4 entities in total)
• Functional Keywords: fab, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 128466.55

Authors

Takahashi, M.,Hanzawa, H. (deposition date: 2019-01-16, release date: 2019-08-07, Last modification date: 2019-10-16)

• Primary citation: Bartz, R.,Fukuchi, K.,Ohtsuka, T.,Lange, T.,Gruner, K.,Watanabe, I.,Hayashi, S.,Oda, Y.,Kawaida, R.,Komori, H.,Kashimoto, Y.,Wirtz, P.,Mayer, J.A.,Redondo-Muller, M.,Saito, S.,Takahashi, M.,Hanzawa, H.,Imai, E.,Martinez, A.,Hanai, M.,Haussinger, D.,Chapman, R.W.,Agatsuma, T.,Bange, J.,Abraham, R.; Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity.; Mol.Cancer Ther., 18:1832-1843, 2019; PubMed: 31350344; DOI: 10.1158/1535-7163.MCT-18-0048

Experimental method

X-RAY DIFFRACTION (2.15 Å)