3KBZ
Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6
Summary for 3KBZ
Entry DOI | 10.2210/pdb3kbz/pdb |
Related | 3KC0 3KC1 |
Descriptor | Fructose-1,6-bisphosphatase 1, {[(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid (3 entities in total) |
Functional Keywords | hydrolase, allosteric enzyme, carbohydrate metabolism, disease mutation, gluconeogenesis, magnesium, metal-binding, polymorphism |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 148105.93 |
Authors | Takahashi, M.,Sone, J.,Hanzawa, H. (deposition date: 2009-10-20, release date: 2010-02-02, Last modification date: 2023-11-01) |
Primary citation | Tsukada, T.,Takahashi, M.,Takemoto, T.,Kanno, O.,Yamane, T.,Kawamura, S.,Nishi, T. Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20:1004-1007, 2010 Cited by PubMed: 20045638DOI: 10.1016/j.bmcl.2009.12.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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