8GZC

Crystal structure of EP300 HAT domain in complex with compound 10

Summary for 8GZC

• Entry DOI: 10.2210/pdb8gzc/pdb
• Descriptor: Histone acetyltransferase p300, ZINC ION, (2~{R},4~{R})-4-fluoranyl-1-[1-(4-methoxyphenyl)cyclohexyl]carbonyl-~{N}-(1~{H}-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: epigenetics, sbdd, histone acetyltransferase, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 106134.95

Authors

Takahashi, M.,Hanzawa, H. (deposition date: 2022-09-26, release date: 2023-01-11, Last modification date: 2023-11-29)

• Primary citation: Kanada, R.,Kagoshima, Y.,Suzuki, T.,Nakamura, A.,Funami, H.,Watanabe, J.,Asano, M.,Takahashi, M.,Ubukata, O.,Suzuki, K.,Aikawa, T.,Sato, K.,Goto, M.,Setsu, G.,Ito, K.,Kihara, K.,Kuroha, M.,Kohno, T.,Ogiwara, H.,Isoyama, T.,Tominaga, Y.,Higuchi, S.,Naito, H.; Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.; J.Med.Chem., 66:695-715, 2023; PubMed: 36572866; DOI: 10.1021/acs.jmedchem.2c01641

Experimental method

X-RAY DIFFRACTION (2 Å)