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3JA7
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CRYO-EM STRUCTURE OF THE BACTERIOPHAGE T4 PORTAL PROTEIN ASSEMBLY AT NEAR-ATOMIC RESOLUTION
Descriptor:Portal protein gp20
Authors:Sun, L., Zhang, X., Gao, S., Rao, P.A., Padilla-Sanchez, V., Chen, Z., Sun, S., Xiang, Y., Subramaniam, S., Rao, V.B., Rossmann, M.G.
Deposit date:2015-04-21
Release date:2015-07-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution.
Nat Commun, 6, 2015
4UIS
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THE CRYOEM STRUCTURE OF HUMAN GAMMA-SECRETASE COMPLEX
Descriptor:GAMMA-SECRETASE, LYSOZYME
Authors:Sun, L., Zhao, L., Yang, G., Yan, C., Zhou, R., Zhou, X., Xie, T., Zhao, Y., Wu, S., Li, X., Shi, Y.
Deposit date:2015-04-03
Release date:2015-06-10
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural Basis of Human Gamma-Secretase Assembly.
Proc.Natl.Acad.Sci.USA, 112, 2015
6DIJ
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STRUCTURE OF THE EVA71 STRAIN 11316 CAPSID
Descriptor:VP1, VP2, VP3, ...
Authors:Sun, L., Lee, H., Thibaut, H.J., Rivero-Buceta, E., Martinez-Gualda, B., Delang, L., Leyssen, P., Gago, F., San-Felix, A., Hafenstein, S., Mirabelli, C., Neyts, J.
Deposit date:2018-05-23
Release date:2019-05-01
Last modified:2019-05-22
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Viral engagement with host (co-)receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.
Plos Pathog., 15, 2019
6DIZ
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EV-A71 STRAIN 11316 COMPLEXED WITH TRYPTOPHAN DENDRIMER MADAL_0385
Descriptor:VP1, VP2, VP3, ...
Authors:Sun, L., Lee, H., Thibaut, H.J., Rivero-Buceta, E., Martinez-Gualda, B., Delang, L., Leyssen, P., Gago, F., San-Felix, A., Hafenstein, S., Mirabelli, C., Neyts, J.
Deposit date:2018-05-24
Release date:2019-04-24
Last modified:2019-05-22
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Viral engagement with host (co-)receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.
Plos Pathog., 15, 2019
1P5J
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN SERINE DEHYDRATASE
Descriptor:L-serine dehydratase, PYRIDOXAL-5'-PHOSPHATE
Authors:Sun, L., Liu, Y., Rao, Z.
Deposit date:2003-04-27
Release date:2004-06-01
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallization and preliminary crystallographic analysis of human serine dehydratase.
Acta Crystallogr.,Sect.D, 59, 2003
2LJ4
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SOLUTION STRUCTURE OF THE TBPIN1
Descriptor:Peptidyl-prolyl cis-trans isomerase/rotamase, putative
Authors:Sun, L., Lin, D., Zhao, Y.
Deposit date:2011-09-06
Release date:2012-08-22
Method:SOLUTION NMR
Cite:Solution Structural Analysis of the Single-Domain Parvulin TbPin1
Plos One, 7, 2012
3UA3
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CRYSTAL STRUCTURE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT5 IN COMPLEX WITH SAH
Descriptor:Protein arginine N-methyltransferase 5, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Sun, L., Wang, M., Lv, Z., Yang, N., Liu, Y., Bao, S., Gong, W., Xu, R.M.
Deposit date:2011-10-20
Release date:2011-12-14
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
3UA4
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CRYSTAL STRUCTURE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT5
Descriptor:Protein arginine N-methyltransferase 5, GLYCEROL
Authors:Sun, L., Wang, M., Lv, Z., Yang, N., Liu, Y., Bao, S., Gong, W., Xu, R.M.
Deposit date:2011-10-21
Release date:2011-12-14
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
3UYI
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CRYSTAL STRUCTURE OF PERAKINE REDUCTASE, FOUNDER MEMBER OF A NOVEL AKR SUBFAMILY WITH UNIQUE CONFORMATIONAL CHANGES DURING NADPH BINDING
Descriptor:Perakine reductase
Authors:Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.
Deposit date:2011-12-06
Release date:2012-02-22
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.313 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
3V0S
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CRYSTAL STRUCTURE OF PERAKINE REDUCTASE, FOUNDER MEMBER OF A NOVEL AKR SUBFAMILY WITH UNIQUE CONFORMATIONAL CHANGES DURING NADPH BINDING
Descriptor:Perakine reductase, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE
Authors:Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.
Deposit date:2011-12-08
Release date:2012-02-22
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.773 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
3V0T
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CRYSTAL STRUCTURE OF PERAKINE REDUCTASE, FOUNDER MEMBER OF A NOVEL AKR SUBFAMILY WITH UNIQUE CONFORMATIONAL CHANGES DURING NADPH BINDING
Descriptor:Perakine Reductase, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE
Authors:Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.
Deposit date:2011-12-08
Release date:2012-02-22
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.333 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
3V0U
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CRYSTAL STRUCTURE OF PERAKINE REDUCTASE, FOUNDER MEMBER OF A NOVEL AKR SUBFAMILY WITH UNIQUE CONFORMATIONAL CHANGES DURING NADPH BINDING
Descriptor:Perakine reductase
Authors:Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.
Deposit date:2011-12-08
Release date:2012-02-22
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
4JPN
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BACTERIOPHAGE PHIX174 H PROTEIN RESIDUES 143-221
Descriptor:Minor spike protein H
Authors:Sun, L., Young, L.N., Boudko, S.B., Fokine, A., Zhang, X., Rossmann, M.G., Fane, B.A.
Deposit date:2013-03-19
Release date:2013-12-11
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection.
Nature, 505, 2014
4JPP
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BACTERIOPHAGE PHIX174 H PROTEIN RESIDUES 143-282
Descriptor:Minor spike protein H
Authors:Sun, L., Young, L.N., Boudko, S.B., Fokine, A., Zhang, X., Rossmann, M.G., Fane, B.A.
Deposit date:2013-03-19
Release date:2013-12-11
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection.
Nature, 505, 2014
4XOI
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STRUCTURE OF HSANILLIN BOUND WITH RHOA(Q63L) AT 2.1 ANGSTROMS RESOLUTION
Descriptor:Transforming protein RhoA, Actin-binding protein anillin, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Sun, L., Guan, R., Lee, I.-J., Liu, Y., Chen, M., Wang, J., Wu, J., Chen, Z.
Deposit date:2015-01-16
Release date:2015-07-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Mechanistic insights into the anchorage of the contractile ring by anillin and mid1
Dev.Cell, 33, 2015
5KNN
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EVOLUTIONARY GAIN OF ALANINE MISCHARGING TO NON-COGNATE TRNAS WITH A G4:U69 BASE PAIR
Descriptor:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE
Authors:Sun, L., He, W., Yang, X.-L.
Deposit date:2016-06-28
Release date:2016-09-28
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.
J.Am.Chem.Soc., 138, 2016
5T5S
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-08-31
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T76
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-09-02
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
4OFB
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CRYSTAL STRUCTURE OF HUMAN BRCA1 BRCT IN COMPLEX WITH NONPHOSPHOPEPTIDE INHIBITOR
Descriptor:Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor
Authors:Sun, L., Edwards, R.A., Glover, J.N.M.
Deposit date:2014-01-14
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
Acs Chem.Biol., 10, 2015
4XOH
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MECHANISTIC INSIGHTS INTO ANCHORAGE OF THE CONTRACTILE RING FROM YEAST TO HUMANS
Descriptor:Division mal foutue 1 protein
Authors:Chen, Z., Wu, J.-Q., Wang, J., Guan, R., Sun, L., Lee, I.-J., Liu, Y., Chen, M.
Deposit date:2015-01-16
Release date:2015-07-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Mechanistic insights into the anchorage of the contractile ring by anillin and mid1
Dev.Cell, 33, 2015
5U6K
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CRYSTAL STRUCTURE OF TOPBP1 BRCT4/5 IN COMPLEX WITH A BLM PHOSPHOPEPTIDE
Descriptor:DNA topoisomerase 2-binding protein 1, Bloom Sydrome recQ helicase like protein (BLM)
Authors:Glover, J.N.M., Sun, L., Edwards, R.A.
Deposit date:2016-12-08
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insight into BLM Recognition by TopBP1.
Structure, 25, 2017
6IJZ
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STRUCTURE OF A PLANT CATION CHANNEL
Descriptor:Calcium permeable stress-gated cation channel 1
Authors:Sun, L., Wang, J., Liu, X.
Deposit date:2018-10-12
Release date:2018-12-12
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2.
Nat Commun, 9, 2018
3G5N
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TRIPLE LIGAND OCCUPANCY CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 IN COMPLEX WITH THE INHIBITOR 1-BIPHENYL-4-METHYL-1H-IMIDAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(biphenyl-4-ylmethyl)-1H-imidazole, ...
Authors:Gay, S.C., Sun, L., Maekawa, K., Halpert, J.R., Stout, C.D.
Deposit date:2009-02-05
Release date:2009-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
3G93
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SINGLE LIGAND OCCUPANCY CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 IN COMPLEX WITH THE INHIBITOR 1-BIPHENYL-4-METHYL-1H-IMIDAZOLE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(biphenyl-4-ylmethyl)-1H-imidazole
Authors:Gay, S.C., Sun, L., Maekawa, K., Halpert, J.R., Stout, C.D.
Deposit date:2009-02-12
Release date:2009-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
3EOP
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CRYSTAL STRUCTURE OF THE DUF55 DOMAIN OF HUMAN THYMOCYTE NUCLEAR PROTEIN 1
Descriptor:Thymocyte nuclear protein 1, SULFATE ION
Authors:Yu, F., Song, A., Xu, C., Sun, L., Li, L., Tang, L., Hu, H., He, J.
Deposit date:2008-09-29
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry
Acta Crystallogr.,Sect.D, 65, 2009