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5NQC
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BU of 5nqc by Molmil
CK2alpha in complex with NMR154
Descriptor: (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CHLORIDE ION, Casein kinase II subunit alpha
Authors:Seetoh, W.-G, Stubbs, C.J.
Deposit date:2017-04-19
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Disrupting the CK2alpha-CK2beta protein-protein interaction within the protein kinase CK2 heterotetramer using a fragment-based approach
To Be Published
4E9D
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BU of 4e9d by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide
Descriptor: 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide, GLYCEROL, Serine/threonine-protein kinase PLK1
Authors:Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C.
Deposit date:2012-03-21
Release date:2012-10-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew.Chem.Int.Ed.Engl., 51, 2012
4E9C
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BU of 4e9c by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, LDPPLHSpTA phosphopeptide, ...
Authors:Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C.
Deposit date:2012-03-21
Release date:2012-10-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew. Chem. Int. Ed. Engl., 51, 2012
3P2Z
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BU of 3p2z by Molmil
Polo-like kinase I Polo-box domain in complex with PLHSpTA phosphopeptide from PBIP1
Descriptor: GLYCEROL, Serine/threonine-protein kinase PLK1, phosphopeptide
Authors:Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C.
Deposit date:2010-10-04
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
3P36
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BU of 3p36 by Molmil
Polo-like kinase I Polo-box domain in complex with DPPLHSpTA phosphopeptide from PBIP1
Descriptor: GLYCEROL, PHOSPHATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C.
Deposit date:2010-10-04
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
7B42
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BU of 7b42 by Molmil
Crystal structure of c-MET bound by compound 8
Descriptor: 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3Q
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BU of 7b3q by Molmil
Crystal structure of c-MET bound by compound 1
Descriptor: 1-(phenylmethyl)-5~{H}-pyrrolo[3,2-c]pyridin-4-one, Hepatocyte growth factor receptor, SULFATE ION
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B40
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BU of 7b40 by Molmil
Crystal structure of c-MET bound by compound 6
Descriptor: 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3W
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BU of 7b3w by Molmil
Crystal structure of c-MET bound by compound 4
Descriptor: 1,2-ETHANEDIOL, 3-(6-fluoranyl-1~{H}-indazol-4-yl)-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B43
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BU of 7b43 by Molmil
Crystal structure of c-MET bound by compound 9
Descriptor: 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3Z
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BU of 7b3z by Molmil
Crystal structure of c-MET bound by compound 5
Descriptor: 3-[3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3V
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BU of 7b3v by Molmil
Crystal structure of c-MET bound by compound 3
Descriptor: 3-(3-methyl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B44
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BU of 7b44 by Molmil
Crystal structure of c-MET bound by compound S1
Descriptor: 5-methoxy-1~{H}-indazole, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor, ...
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3T
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BU of 7b3t by Molmil
Crystal structure of c-MET bound by compound 2
Descriptor: 3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridine, CHLORIDE ION, Hepatocyte growth factor receptor, ...
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B41
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BU of 7b41 by Molmil
Crystal structure of c-MET bound by compound 7
Descriptor: 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
9F9A
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BU of 9f9a by Molmil
Crystal structure of MUS81-EME1 bound by compound 12.
Descriptor: 2-naphthalen-2-yl-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
Authors:Collie, G.W.
Deposit date:2024-05-07
Release date:2024-06-19
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.911 Å)
Cite:Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F9M
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BU of 9f9m by Molmil
Crystal structure of MUS81-EME1 bound by compound 21.
Descriptor: 5-oxidanyl-4-oxidanylidene-1-(4-piperazin-1-ylphenyl)pyridine-3-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
Authors:Collie, G.W.
Deposit date:2024-05-08
Release date:2024-06-19
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.469 Å)
Cite:Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F9K
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BU of 9f9k by Molmil
Crystal structure of MUS81-EME1 bound by compound 15.
Descriptor: 5-oxidanyl-6-oxidanylidene-2-(4-phenylphenyl)-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
Authors:Collie, G.W.
Deposit date:2024-05-07
Release date:2024-07-03
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.728 Å)
Cite:Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F99
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BU of 9f99 by Molmil
Crystal structure of MUS81-EME1 bound by compound 10.
Descriptor: 2-(4-chlorophenyl)-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
Authors:Collie, G.W.
Deposit date:2024-05-07
Release date:2024-06-19
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F9L
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BU of 9f9l by Molmil
Crystal structure of MUS81-EME1 bound by compound 16.
Descriptor: 2-[2-[4-(cyanomethyl)phenyl]phenyl]-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
Authors:Collie, G.W.
Deposit date:2024-05-07
Release date:2024-07-03
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F98
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BU of 9f98 by Molmil
Crystal structure of MUS81-EME1, apo form.
Descriptor: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81
Authors:Collie, G.W.
Deposit date:2024-05-07
Release date:2024-07-03
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9EYU
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BU of 9eyu by Molmil
Human PRMT5 in complex with AZ compound 1
Descriptor: (1~{S})-2-[(2-carbamimidamido-1,3-thiazol-5-yl)methyl]-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9EYW
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BU of 9eyw by Molmil
Human PRMT5 in complex with AZ compound 21
Descriptor: (3~{S})-2-[(5-azanyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9EYX
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BU of 9eyx by Molmil
Human PRMT5 in complex with AZ compound 28
Descriptor: (3~{S})-2-[(5-azanyl-6-fluoranyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9EYV
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BU of 9eyv by Molmil
Human PRMT5 in complex with AZ compound 12
Descriptor: (1~{S})-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-2-(1~{H}-pyrrolo[3,2-b]pyridin-2-ylmethyl)-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024

 

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