Author results

1IKA
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STRUCTURE OF ISOCITRATE DEHYDROGENASE WITH ALPHA-KETOGLUTARATE AT 2.7 ANGSTROMS RESOLUTION: CONFORMATIONAL CHANGES INDUCED BY DECARBOXYLATION OF ISOCITRATE
Descriptor:ISOCITRATE DEHYDROGENASE, CALCIUM ION, 2-OXOGLUTARIC ACID
Authors:Stoddard, B.L., Koshland Junior, D.E.
Deposit date:1993-06-15
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7-A resolution: conformational changes induced by decarboxylation of isocitrate.
Biochemistry, 32, 1993
3GCH
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CHEMISTRY OF CAGED ENZYMES. BINDING OF PHOTOREVERSIBLE CINNAMATES TO CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN, TRANS-O-HYDROXY-ALPHA-METHYL CINNAMATE
Authors:Stoddard, B.L., Ringe, D., Petsko, G.A.
Deposit date:1989-09-25
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and activity of two photoreversible cinnamates bound to chymotrypsin.
Biochemistry, 29, 1990
3SDP
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THE 2.1 ANGSTROMS RESOLUTION STRUCTURE OF IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS
Descriptor:IRON SUPEROXIDE DISMUTASE, FE (III) ION
Authors:Stoddard, B.L., Ringe, D., Petsko, G.A.
Deposit date:1991-05-06
Release date:1993-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The 2.1-A resolution structure of iron superoxide dismutase from Pseudomonas ovalis.
Biochemistry, 29, 1990
4GCH
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STRUCTURE AND ACTIVITY OF TWO PHOTOREVERSIBLE CINNAMATES BOUND TO CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN A, 3-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACID
Authors:Stoddard, B.L., Ringe, D., Petsko, G.A.
Deposit date:1989-09-25
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and activity of two photoreversible cinnamates bound to chymotrypsin.
Biochemistry, 29, 1990
5GCH
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CHEMISTRY OF CAGED ENZYMES /II$. PHOTOACTIVATION OF INHIBITED CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN A
Authors:Stoddard, B.L., Ringe, D., Petsko, G.A.
Deposit date:1989-09-25
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Photolysis and deacylation of inhibited chymotrypsin.
Biochemistry, 29, 1990
1BL5
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ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, 2-OXOGLUTARIC ACID, ...
Authors:Stoddard, B.L., Cohen, B., Brubaker, M., Mesecar, A., Koshland Junior, D.E.
Deposit date:1998-07-23
Release date:1999-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs.
Nat.Struct.Biol., 5, 1998
4Z1X
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CRYSTAL STRUCTURE OF LAGLIDADG HOMING ENDONUCLEASE I-GZEII IN COMPLEX WITH DNA TARGET
Descriptor:DNA (27-MER), LAGLIDADG endonuclease, CALCIUM ION
Authors:Stoddard, B.L., Lambert, A.R., Kulshina, N.
Deposit date:2015-03-27
Release date:2015-04-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of LAGLIDADG homing endonuclease I-GzeII in complex with DNA target
To Be Published
5IEN
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STRUCTURE OF CDL2.2, A COMPUTATIONALLY DESIGNED VITAMIN-D3 BINDER
Descriptor:CDL2.2, 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL, GLYCEROL
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2016-02-25
Release date:2017-03-01
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.089 Å)
Cite:Structure of CDL2.2, a computationally designed Vitamin-D3 binder
To be published
5IEO
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STRUCTURE OF CDL2.3A, A COMPUTATIONALLY DESIGNED VITAMIN-D3 BINDER
Descriptor:CDL2.3a, 1,2-ETHANEDIOL, 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2016-02-25
Release date:2017-03-01
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structure of CDL2.3a, a computationally designed Vitamin-D3 binder
To be published
5IEP
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STRUCTURE OF CDL2.3B, A COMPUTATIONALLY DESIGNED VITAMIN-D3 BINDER
Descriptor:CDL2.3b, 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2016-02-25
Release date:2017-03-01
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Structure of CDL2.3b, a computationally designed Vitamin-D3 binder
To be published
5T2H
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ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE HUMAN TCRA GENE; HARBORS 43 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI
Descriptor:I-OnuI_e-hTCRa, DNA (26-MER), CALCIUM ION
Authors:Stoddard, B.L., Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.517 Å)
Cite:TBD
To Be Published
5T2N
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ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE ANOPHELES AGAP007280 GENE; HARBORS 38 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI
Descriptor:I-OnuI_e-ag007820, DNA (26-MER), CALCIUM ION
Authors:Stoddard, B.L., Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.079 Å)
Cite:TBD
To Be Published
5T2O
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ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE ANOPHELES AGAP011377 GENE; HARBORS 53 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI
Descriptor:I-OnuI_e-ag011377, DNA (26-MER), CALCIUM ION
Authors:Stoddard, B.L., Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:TBD
To Be Published
5T8D
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ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE HIV INTEGRASE GENE; HARBORS 47 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI
Descriptor:I-OnuI_e-vHIVInt_v2, DNA (26-MER), CALCIUM ION
Authors:Stoddard, B.L., Werther, R., Lambert, A.R.
Deposit date:2016-09-07
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:TBD
To Be Published
1AI2
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ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED)
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRATE CALCIUM COMPLEX
Authors:Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.
Deposit date:1997-04-30
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science, 277, 1997
1AI3
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ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES
Descriptor:ISOCITRATE DEHYDROGENASE, NICOTINAMIDE-(6-DEAMINO-6-HYDROXY-ADENINE)-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ...
Authors:Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.
Deposit date:1997-04-30
Release date:1997-11-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science, 277, 1997
1P8K
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THE STRUCTURE AND DNA RECOGNITION OF A BIFUNCTIONAL HOMING ENDONUCLEASE AND GROUP I INTRON SPLICING FACTOR
Descriptor:5'-D(P*GP*CP*GP*CP*GP*CP*TP*GP*AP*GP*GP*AP*GP*GP*TP*TP*TP*C)-3', 5'-D(P*TP*CP*TP*GP*TP*AP*AP*AP*GP*CP*GP*CP*A)-3', 5'-D(P*GP*CP*GP*CP*TP*TP*TP*AP*CP*AP*GP*AP*GP*AP*AP*A)-3', ...
Authors:Stoddard, B.L., Bolduc, J.M.
Deposit date:2003-05-07
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor.
Genes Dev., 17, 2003
2R7E
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CRYSTAL STRUCTURE ANALYSIS OF COAGULATION FACTOR VIII
Descriptor:Coagulation factor VIII, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Stoddard, B.L., Shen, B.W.
Deposit date:2007-09-07
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The tertiary structure and domain organization of coagulation factor VIII.
Blood, 111, 2008
3B5L
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CRYSTAL STRUCTURE OF A NOVEL ENGINEERED RETROALDOLASE: RA-61
Descriptor:Endoxylanase, SULFATE ION, AMMONIUM ION
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2007-10-26
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:De novo computational design of retro-aldol enzymes.
Science, 319, 2008
3HOJ
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CRYSTAL STRUCTURE OF A NOVEL ENGINEERED RETROALDOLASE: RA-22
Descriptor:RETROALDOLASE-22
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2009-06-02
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:De Novo Computational Design of Retro-Aldol Enzymes
Science, 319, 2008
4J8T
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ENGINEERED DIGOXIGENIN BINDER DIG10.2
Descriptor:Engineered Digoxigenin binder protein DIG10.2, DIGOXIGENIN
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2013-02-14
Release date:2013-06-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Computational design of ligand-binding proteins with high affinity and selectivity.
Nature, 501, 2013
4J9A
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ENGINEERED DIGOXIGENIN BINDER DIG10.3
Descriptor:Engineered Digoxigenin binder protein DIG10.3, DIGOXIGENIN
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2013-02-15
Release date:2013-06-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Computational design of ligand-binding proteins with high affinity and selectivity.
Nature, 501, 2013
5IER
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STRUCTURE OF A COMPUTATIONALLY DESIGNED 17-OHP BINDER
Descriptor:OHP9, (9beta)-17-hydroxypregn-4-ene-3,20-dione, SULFATE ION, ...
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2016-02-25
Release date:2017-03-01
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Sampling and energy evaluation challenges in ligand binding protein design.
Protein Sci., 26, 2017
5IF6
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STRUCTURE OF A COMPUTATIONALLY DESIGNED 17-OHP BINDER
Descriptor:OHP9_1c, (9beta)-17-hydroxypregn-4-ene-3,20-dione, SODIUM ION
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2016-02-25
Release date:2017-03-01
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Sampling and energy evaluation challenges in ligand binding protein design.
Protein Sci., 26, 2017
1IQD
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HUMAN FACTOR VIII C2 DOMAIN COMPLEXED TO HUMAN MONOCLONAL BO2C11 FAB.
Descriptor:HUMAN MONOCLONAL BO2C11 FAB LIGHT CHAIN, HUMAN MONOCLONAL BO2C11 FAB HEAVY CHAIN, HUMAN FACTOR VIII
Authors:Spiegel Jr., P.C., Jacquemin, M., Saint-Remy, J.M., Stoddard, B.L., Pratt, K.P.
Deposit date:2001-07-21
Release date:2001-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.
Blood, 98, 2001