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6XVI
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BU of 6xvi by Molmil
Crystal structure of Megabody Mb-Nb207-c7HopQ_A12
Descriptor: Outer membrane protein,Outer membrane protein,Mb-Nb207-c7HopQ_A12
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-22
Release date:2021-01-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6XUX
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BU of 6xux by Molmil
Crystal structure of Megabody Mb-Nb207-cYgjK_NO
Descriptor: CALCIUM ION, Nanobody,Glucosidase YgjK,Glucosidase YgjK,Nanobody
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-21
Release date:2021-01-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.90000641 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6XV8
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BU of 6xv8 by Molmil
Crystal structure of Megabody Mb-Nb207-c7HopQ_G10
Descriptor: Outer membrane protein
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-21
Release date:2021-01-13
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
5JQH
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BU of 5jqh by Molmil
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, CHOLESTEROL, Endolysin,Beta-2 adrenergic receptor, ...
Authors:Staus, D.P, Strachan, R.T, Manglik, A, Pani, B, Kahsai, A.W, Kim, T.H, Wingler, L.M, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, A.C, Pardon, E, Steyaert, J, Weis, W.I, Prosser, R.S, Kobilka, B.K, Costa, T, Lefkowitz, R.J.
Deposit date:2016-05-05
Release date:2016-07-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Nature, 535, 2016
3SN6
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BU of 3sn6 by Molmil
Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Descriptor: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ...
Authors:Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
3K74
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BU of 3k74 by Molmil
Disruption of protein dynamics by an allosteric effector antibody
Descriptor: Dihydrofolate reductase, Nanobody
Authors:Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J.
Deposit date:2009-10-12
Release date:2010-10-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
8V8K
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BU of 8v8k by Molmil
Crystal Structure of Nanobody NbE
Descriptor: Nanobody NbE
Authors:Koehl, A, Manglik, A, Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Steyaert, J, Ballet, S, Boland, A, Stoeber, M.
Deposit date:2023-12-05
Release date:2024-09-11
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of mu-opioid receptor targeting by a nanobody antagonist.
Nat Commun, 15, 2024
1BIR
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BU of 1bir by Molmil
RIBONUCLEASE T1, PHE 100 TO ALA MUTANT COMPLEXED WITH 2' GMP
Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1
Authors:Doumen, J, Gonciarz, M, Zegers, I, Loris, R, Wyns, L, Steyaert, J.
Deposit date:1996-01-04
Release date:1996-08-17
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A catalytic function for the structurally conserved residue Phe 100 of ribonuclease T1.
Protein Sci., 5, 1996
1KIE
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BU of 1kie by Molmil
Inosine-adenosine-guanosine preferring nucleoside hydrolase from Trypanosoma vivax: Asp10Ala mutant in complex with 3-deaza-adenosine
Descriptor: 3-DEAZA-ADENOSINE, CALCIUM ION, NICKEL (II) ION, ...
Authors:Versees, W, Decanniere, K, Van Holsbeke, E, Devroede, N, Steyaert, J.
Deposit date:2001-12-03
Release date:2002-05-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.
J.Biol.Chem., 277, 2002
1LOY
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BU of 1loy by Molmil
X-ray structure of the H40A/E58A mutant of Ribonuclease T1 complexed with 3'-guanosine monophosphate
Descriptor: CALCIUM ION, GUANOSINE-3'-MONOPHOSPHATE, Guanyl-specific ribonuclease T1
Authors:Mignon, P, Steyaert, J, Loris, R, Geerlings, P, Loverix, S.
Deposit date:2002-05-07
Release date:2002-08-21
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study
J.Biol.Chem., 277, 2002
6QD6
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BU of 6qd6 by Molmil
Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207
Descriptor: CHLORIDE ION, Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207
Authors:Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkonig, A, Zogg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J.
Deposit date:2018-12-31
Release date:2019-12-18
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Nat.Methods, 18, 2021
1LRA
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BU of 1lra by Molmil
CRYSTALLOGRAPHIC STUDY OF GLU 58 ALA RNASE T1(ASTERISK)2'-GUANOSINE MONOPHOSPHATE AT 1.9 ANGSTROMS RESOLUTION
Descriptor: GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1, SODIUM ION
Authors:Pletinckx, J, Steyaert, J, Choe, H.-W, Heinemann, U, Wyns, L.
Deposit date:1993-10-01
Release date:1994-01-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic study of Glu58Ala RNase T1 x 2'-guanosine monophosphate at 1.9-A resolution.
Biochemistry, 33, 1994
4CND
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BU of 4cnd by Molmil
Crystal structure of E.coli TrmJ
Descriptor: DI(HYDROXYETHYL)ETHER, TRNA (CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
4CNE
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BU of 4cne by Molmil
Crystal structure of E.coli TrmJ in complex with S-adenosyl-L- homocysteine
Descriptor: DI(HYDROXYETHYL)ETHER, S-ADENOSYL-L-HOMOCYSTEINE, TRNA (CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
4CNF
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BU of 4cnf by Molmil
Crystal structure of Sulfolobus acidocaldarius TrmJ
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
4CNG
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BU of 4cng by Molmil
Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine
Descriptor: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, SPOU RRNA METHYLASE
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
6EQI
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BU of 6eqi by Molmil
Structure of PINK1 bound to ubiquitin
Descriptor: GLYCEROL, Nb696, Serine/threonine-protein kinase PINK1, ...
Authors:Schubert, A.F, Gladkova, C, Pardon, E, Wagstaff, J.L, Freund, S.M.V, Steyaert, J, Maslen, S, Komander, D.
Deposit date:2017-10-13
Release date:2017-11-08
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of PINK1 in complex with its substrate ubiquitin.
Nature, 552, 2017
6C9W
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BU of 6c9w by Molmil
Crystal Structure of a ligand bound LacY/Nanobody Complex
Descriptor: 4-nitrophenyl alpha-D-galactopyranoside, Lactose permease, Nanobody9047, ...
Authors:Kumar, H, Finer-Moore, J.S, Jiang, X, Smirnova, I, Kasho, V, Pardon, E, Steyaert, J, Kaback, H.R, Stroud, R.M.
Deposit date:2018-01-29
Release date:2018-08-15
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of a ligand-bound LacY-Nanobody Complex.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1YOE
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BU of 1yoe by Molmil
Crystal structure of a the E. coli pyrimidine nucleoside hydrolase YbeK with bound ribose
Descriptor: CALCIUM ION, Hypothetical protein ybeK, alpha-D-ribofuranose
Authors:Muzzolini, L, Versees, W, Steyaert, J, Degano, M.
Deposit date:2005-01-27
Release date:2006-01-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of the E. coli pyrimidine nucleoside hydrolase YbeK with bound ribose
To be Published
7ZC2
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BU of 7zc2 by Molmil
Dipeptide and tripeptide Permease C (DtpC)
Descriptor: Amino acid/peptide transporter
Authors:Killer, M, Finocchio, G, Pardon, E, Steyaert, J, Loew, C.
Deposit date:2022-03-25
Release date:2022-07-06
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Front Mol Biosci, 9, 2022
7ZRA
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BU of 7zra by Molmil
Crystal structure of E.coli LexA in complex with nanobody NbSOS1(Nb14497)
Descriptor: 1,2-ETHANEDIOL, LexA repressor, Nanobody NbSOS1 (Nb14497)
Authors:Maso, L, Vascon, F, Chinellato, M, Pardon, E, Steyaert, J, Angelini, A, Tondi, D, Cendron, L.
Deposit date:2022-05-04
Release date:2022-10-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.
Structure, 30, 2022
8G8W
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BU of 8g8w by Molmil
Molecular mechanism of nucleotide inhibition of human uncoupling protein 1
Descriptor: CARDIOLIPIN, GUANOSINE-5'-TRIPHOSPHATE, Mitochondrial brown fat uncoupling protein 1, ...
Authors:Gogoi, P, Jones, S.A, Ruprecht, J.J, King, M.S, Lee, Y, Zogg, T, Pardon, E, Chand, D, Steimle, S, Copeman, D, Cotrim, C.A, Steyaert, J, Crichton, P.G, Moiseenkova-Bell, V, Kunji, E.R.S.
Deposit date:2023-02-20
Release date:2023-06-07
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of purine nucleotide inhibition of human uncoupling protein 1.
Sci Adv, 9, 2023
6B73
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BU of 6b73 by Molmil
Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Descriptor: CHOLESTEROL, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, Nanobody, ...
Authors:Che, T, Majumdar, S, Zaidi, S.A, Kormos, C, McCorvy, J.D, Wang, S, Mosier, P.D, Uprety, R, Vardy, E, Krumm, B.E, Han, G.W, Lee, M.Y, Pardon, E, Steyaert, J, Huang, X.P, Strachan, R.T, Tribo, A.R, Pasternak, G.W, Carroll, I.F, Stevens, R.C, Cherezov, V, Katritch, V, Wacker, D, Roth, B.L.
Deposit date:2017-10-03
Release date:2018-01-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
3P0G
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BU of 3p0g by Molmil
Structure of a nanobody-stabilized active state of the beta2 adrenoceptor
Descriptor: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Beta-2 adrenergic receptor, Lysozyme, ...
Authors:Rasmussen, S.G.F, Choi, H.-J, Fung, J.J, Pardon, E, Casarosa, P, Chae, P.S, DeVree, B.T, Rosenbaum, D.M, Thian, F.S, Kobilka, T.S, Schnapp, A, Konetzki, I, Sunahara, R.K, Gellman, S.H, Pautsch, A, Steyaert, J, Weis, W.I, Kobilka, B.K.
Deposit date:2010-09-28
Release date:2011-01-19
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Nature, 469, 2011
3BIR
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BU of 3bir by Molmil
DISECTING HISTIDINE INTERACTIONS IN RIBONUCLEASE T1 BY ASN AND GLN SUBSTITUTIONS
Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1
Authors:Doumen, J, Steyaert, J.
Deposit date:1997-06-27
Release date:1997-12-31
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissecting histidine interactions of ribonuclease T1 with asparagine and glutamine replacements: analysis of double mutant cycles at one position.
J.Mol.Biol., 275, 1998

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