Author results

1IL6
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HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:INTERLEUKIN-6
Authors:Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., Mcdonagh, T., Kay, L.E., Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
2IL6
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HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES
Descriptor:INTERLEUKIN-6
Authors:Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., Mcdonagh, T., Kay, L.E., Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
1S1E
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CRYSTAL STRUCTURE OF KV CHANNEL-INTERACTING PROTEIN 1 (KCHIP-1)
Descriptor:Kv channel interacting protein 1, CALCIUM ION
Authors:Scannevin, R.H., Wang, K.-W., Jow, F., Megules, J., Kopsco, D.C., Edris, W., Carroll, K.C., Lu, Q., Xu, W.-X., Xu, Z.-B., Katz, A.H., Olland, S., Lin, L., Taylor, M., Stahl, M., Malakian, K., Somers, W., Mosyak, L., Bowlby, M.R., Chanda, P., Rhodes, K.J.
Deposit date:2004-01-06
Release date:2005-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron, 41, 2004
1S1G
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CRYSTAL STRUCTURE OF KV4.3 T1 DOMAIN
Descriptor:Potassium voltage-gated channel subfamily D member 3, ZINC ION
Authors:Scannevin, R.H., Wang, K.W., Jow, F., Megules, J., Kopsco, D.C., Edris, W., Carroll, K.C., Lu, Q., Xu, W.X., Xu, Z.B., Katz, A.H., Olland, S., Lin, L., Taylor, M., Stahl, M., Malakian, K., Somers, W., Mosyak, L., Bowlby, M.R., Chanda, P., Rhodes, K.J.
Deposit date:2004-01-06
Release date:2004-03-23
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron, 41, 2004
2RJP
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CRYSTAL STRUCTURE OF ADAMTS4 WITH INHIBITOR BOUND
Descriptor:ADAMTS-4, ZINC ION, CALCIUM ION, ...
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-15
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
2RJQ
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CRYSTAL STRUCTURE OF ADAMTS5 WITH INHIBITOR BOUND
Descriptor:ADAMTS-5, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-15
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
3B2Z
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CRYSTAL STRUCTURE OF ADAMTS4 (APO FORM)
Descriptor:ADAMTS-4, ZINC ION, CALCIUM ION
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-19
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
1ALU
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HUMAN INTERLEUKIN-6
Descriptor:INTERLEUKIN-6, SULFATE ION, L(+)-TARTARIC ACID
Authors:Somers, W.S., Stahl, M., Seehra, J.S.
Deposit date:1997-06-03
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
EMBO J., 16, 1997
1CJY
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HUMAN CYTOSOLIC PHOSPHOLIPASE A2
Descriptor:PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2), CALCIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S.
Deposit date:1999-04-20
Release date:2000-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
Cell(Cambridge,Mass.), 97, 1999
1F46
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THE BACTERIAL CELL-DIVISION PROTEIN ZIPA AND ITS INTERACTION WITH AN FTSZ FRAGMENT REVEALED BY X-RAY CRYSTALLOGRAPHY
Descriptor:CELL DIVISION PROTEIN ZIPA
Authors:Mosyak, L., Zhang, Y., Glasfeld, E., Stahl, M., Somers, W.S.
Deposit date:2000-06-07
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
EMBO J., 19, 2000
1F47
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THE BACTERIAL CELL-DIVISION PROTEIN ZIPA AND ITS INTERACTION WITH AN FTSZ FRAGMENT REVEALED BY X-RAY CRYSTALLOGRAPHY
Descriptor:CELL DIVISION PROTEIN ZIPA, CELL DIVISION PROTEIN FTSZ
Authors:Mosyak, L., Zhang, Y., Glasfeld, E., Stahl, M., Somers, W.S.
Deposit date:2000-06-07
Release date:2001-06-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
EMBO J., 19, 2000
1F7L
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HOLO-(ACYL CARRIER PROTEIN) SYNTHASE IN COMPLEX WITH COENZYME A AT 1.5A
Descriptor:HOLO-(ACYL CARRIER PROTEIN) SYNTHASE, CALCIUM ION, CHLORIDE ION, ...
Authors:Parris, K.D., Lin, L., Tam, A., Mathew, R., Hixon, J., Stahl, M., Fritz, C.C., Seehra, J., Somers, W.S.
Deposit date:2000-06-27
Release date:2001-06-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8, 2000
1F7T
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HOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8A
Descriptor:HOLO-(ACYL CARRIER PROTEIN) SYNTHASE, SODIUM ION, CHLORIDE ION, ...
Authors:Parris, K.D., Lin, L., Tam, A., Mathew, R., Hixon, J., Stahl, M., Fritz, C.C., Seehra, J., Somers, W.S.
Deposit date:2000-06-27
Release date:2001-06-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8, 2000
1F80
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HOLO-(ACYL CARRIER PROTEIN) SYNTHASE IN COMPLEX WITH HOLO-(ACYL CARRIER PROTEIN)
Descriptor:HOLO-(ACYL CARRIER PROTEIN) SYNTHASE, ACYL CARRIER PROTEIN, SODIUM ION
Authors:Parris, K.D., Lin, L., Tam, A., Mathew, R., Hixon, J., Stahl, M., Fritz, C.C., Seehra, J., Somers, W.S.
Deposit date:2000-06-28
Release date:2001-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8, 2000
1W7X
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FACTOR7 - 413 COMPLEX
Descriptor:BLOOD COAGULATION FACTOR VIIA, GLYCEROL, CALCIUM ION, ...
Authors:Ackermann, J., Alig, L., Banner, D.W., Boehm, H.-J., Groebke-Zbinden, K., Hilpert, K., Lave, T., Kuehne, H., Obst-Sander, U., Riederer, M.A., Stahl, M., Tschopp, T.B., Weber, L., Wessel, H.P.
Deposit date:2004-09-14
Release date:2005-10-25
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
1W8B
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FACTOR7 - 413 COMPLEX
Descriptor:BLOOD COAGULATION FACTOR VIIA, CALCIUM ION, (S)-[(R)-2-(4-BENZYLOXY-3-METHOXY-PHENYL)-2-(4-CARBAMIMIDOYL-PHENYLAMINO)-ACETYLAMINO]-PHENYL-ACETIC ACID
Authors:Ackermann, J., Alig, L., Banner, D.W., Boehm, H.-J., Groebke-Zbinden, K., Hilpert, K., Lave, T., Kuehne, H., Obst-Sander, U., Riederer, M.A., Stahl, M., Tschopp, T.B., Weber, L., Wessel, H.P.
Deposit date:2004-09-17
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
2BZ6
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ORALLY AVAILABLE FACTOR7A INHIBITOR
Descriptor:BLOOD COAGULATION FACTOR VIIA, (R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC ACID, SULFATE ION, ...
Authors:Groebke-Zbinden, K., Obst-Sander, U., Hilpert, K., Kuehne, H., Banner, D.W., Boehm, H.J., Stahl, M., Ackermann, J., Alig, L., Weber, L., Wessel, H.P., Riederer, M.A., Tschopp, T.B., Lave, T.
Deposit date:2005-08-11
Release date:2006-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dose-Dependant Antithrombotic Activity of an Orally Active Tissue Factor/Factor Viia Inhibitor without Concomitant Enhancement of Bleeding Propensity.
Bioorg.Med.Chem., 14, 2006
2VVC
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AMINOPYRROLIDINE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, 5-chloro-N-[(3S,4S)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-4-methoxypyrrolidin-3-yl]thiophene-2-carboxamide, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-05
Release date:2009-07-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
2VVU
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AMINOPYRROLIDINE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-11
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
2VVV
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AMINOPYRROLIDINE-RELATED TRIAZOLE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, 5-chloro-N-[1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-1H-1,2,4-triazol-3-yl]thiophene-2-carboxamide, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-12
Release date:2009-07-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
2VWL
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AMINOPYRROLIDINE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3R,5S)-1-{[2-FLUORO-4-(2-OXO-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-5-HYDROXYMETHYL-PYRROLIDIN-3-YL)-AMIDE, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-26
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
2VWM
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AMINOPYRROLIDINE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (4R)-4-{[(5-chlorothiophen-2-yl)carbonyl]amino}-N-(cyclopropylmethyl)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-L-prolinamide, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-26
Release date:2009-07-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
2VWN
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AMINOPYRROLIDINE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-26
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
2VWO
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AMINOPYRROLIDINE FACTOR XA INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE, ...
Authors:Groebke-Zbinden, K., Banner, D.W., Benz, J.M., Blasco, F., Decoret, G., Himber, J., Kuhn, B., Panday, N., Ricklin, F., Risch, P., Schlatter, D., Stahl, M., Unger, R., Haap, W.
Deposit date:2008-06-26
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
3JSZ
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LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1 N293A WITH UDP-GLC
Descriptor:Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE, MAGNESIUM ION
Authors:Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O.
Deposit date:2009-09-11
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
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