1W8B

Factor7 - 413 complex

Summary for 1W8B

• Entry DOI: 10.2210/pdb1w8b/pdb
• Related: 1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1QFK 1W0Y 1W2K 1W7X
• Descriptor: BLOOD COAGULATION FACTOR VIIA, CALCIUM ION, (S)-[(R)-2-(4-BENZYLOXY-3-METHOXY-PHENYL)-2-(4-CARBAMIMIDOYL-PHENYLAMINO)-ACETYLAMINO]-PHENYL-ACETIC ACID, ... (5 entities in total)
• Functional Keywords: serine protease, coagulation, enzyme complex, hydrolase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 34954.04

Authors

Ackermann, J.,Alig, L.,Banner, D.W.,Boehm, H.-J.,Groebke-Zbinden, K.,Hilpert, K.,Lave, T.,Kuehne, H.,Obst-Sander, U.,Riederer, M.A.,Stahl, M.,Tschopp, T.B.,Weber, L.,Wessel, H.P. (deposition date: 2004-09-17, release date: 2005-10-25, Last modification date: 2024-11-06)

Primary citation

Groebke-Zbinden, K.,Obst-Sander, U.,Hilpert, K.,Kuehne, H.,Banner, D.W.,Boehm, H.-J.,Stahl, M.,Ackermann, J.,Alig, L.,Weber, L.,Wessel, H.P.,Riederer, M.A.,Tschopp, T.B.,Lave, T.
Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors
Bioorg.Med.Chem.Lett., 15:5344-, 2005

PubMed Abstract: We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.

PubMed: 16213138
DOI: 10.1016/J.BMCL.2005.04.079

Experimental method

X-RAY DIFFRACTION (3 Å)