2BZ6

Orally available Factor7a inhibitor

Summary for 2BZ6

Entry DOI	10.2210/pdb2bz6/pdb
Related	1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1YGC 1Z6J
Descriptor	BLOOD COAGULATION FACTOR VIIA, (R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC ACID, SULFATE ION, ... (6 entities in total)
Functional Keywords	serine protease, coagulation, enzyme complex, hydrolase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted: P08709 P08709
Total number of polymer chains	2
Total formula weight	34401.28
Authors	Groebke-Zbinden, K.,Obst-Sander, U.,Hilpert, K.,Kuehne, H.,Banner, D.W.,Boehm, H.J.,Stahl, M.,Ackermann, J.,Alig, L.,Weber, L.,Wessel, H.P.,Riederer, M.A.,Tschopp, T.B.,Lave, T. (deposition date: 2005-08-11, release date: 2006-02-22, Last modification date: 2011-07-13)
Primary citation	Groebke-Zbinden, K.,Banner, D.W.,Hilpert, K.,Himber, J.,Lave, T.,Riederer, M.A.,Stahl, M.,Tschopp, T.B.,Obst-Sander, U. Dose-Dependant Antithrombotic Activity of an Orally Active Tissue Factor/Factor Viia Inhibitor without Concomitant Enhancement of Bleeding Propensity. Bioorg.Med.Chem., 14:5357-, 2006 Cited by PubMed: 16621574 DOI: 10.1016/J.BMC.2006.03.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation