Author results

1TAD
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GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4-
Descriptor:TRANSDUCIN-ALPHA, CALCIUM ION, CACODYLATE ION, ...
Authors:Sondek, J., Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1995-01-05
Release date:1995-05-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
Nature, 372, 1994
4K45
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AUTO-INHIBITION AND PHOSPHORYLATION-INDUCED ACTIVATION OF PLC-GAMMA ISOZYMES
Descriptor:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide
Authors:Sondek, J., Hajicek, N.
Deposit date:2013-04-11
Release date:2013-06-26
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes.
Biochemistry, 52, 2013
1GOT
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HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
Descriptor:GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ...
Authors:Lambright, D.G., Sondek, J., Bohm, A., Skiba, N.P., Hamm, H.E., Sigler, P.B.
Deposit date:1996-08-07
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379, 1996
2ZKM
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CRYSTAL STRUCTURE OF PHOSPHOLIPASE C BETA 2
Descriptor:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, CALCIUM ION
Authors:Hicks, S.N., Jezyk, M.R., Gershberg, S., Seifert, J.P., Harden, T.K., Sondek, J.
Deposit date:2008-03-26
Release date:2008-08-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:General and versatile autoinhibition of PLC isozymes
Mol.Cell, 31, 2008
1IHJ
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CRYSTAL STRUCTURE OF THE N-TERMINAL PDZ DOMAIN OF INAD IN COMPLEX WITH A NORPA C-TERMINAL PEPTIDE
Descriptor:InaD, phospholipase C
Authors:Kimple, M.E., Siderovski, D.P., Sondek, J.
Deposit date:2001-04-19
Release date:2001-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
EMBO J., 20, 2001
1KZ7
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF MURINE DBS IN COMPLEX WITH THE PLACENTAL ISOFORM OF HUMAN CDC42
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
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DBSCDC42(Y889F)
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1FOE
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CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor:T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION
Authors:Worthylake, D.K., Rossman, K.L., Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
1JAD
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C-TERMINAL DOMAIN OF TURKEY PLC-BETA
Descriptor:phospholipase C beta, SULFATE ION
Authors:Singer, A.U., Waldo, G.L., Harden, T.K., Sondek, J.
Deposit date:2001-05-30
Release date:2001-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.
Nat.Struct.Biol., 9, 2002
1KI1
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GUANINE NUCLEOTIDE EXCHANGE REGION OF INTERSECTIN IN COMPLEX WITH CDC42
Descriptor:G25K GTP-binding protein, placental isoform, intersectin long form, ...
Authors:Snyder, J.T., Pruitt, W.M., Der, C.J., Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1KJY
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CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, REGULATOR OF G-PROTEIN SIGNALING 14, ...
Authors:Kimple, R.J., Kimple, M.E., Betts, L., Sondek, J., Siderovski, D.P.
Deposit date:2001-12-05
Release date:2002-05-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature, 416, 2002
1LB1
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CRYSTAL STRUCTURE OF THE DBL AND PLECKSTRIN HOMOLOGY DOMAINS OF DBS IN COMPLEX WITH RHOA
Descriptor:Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J., Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1RJ2
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF DBS WITHOUT BOUND GTPASE
Descriptor:Guanine nucleotide exchange factor DBS [Fragment]
Authors:Worthylake, D.K., Rossman, K.L., Sondek, J.
Deposit date:2003-11-18
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure, 12, 2004
1S21
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CRYSTAL STRUCTURE OF AVRPPHF ORF2, A TYPE III EFFECTOR FROM P. SYRINGAE
Descriptor:ORF2
Authors:Singer, A.U., Desveaux, D., Betts, L., Chang, J.H., Nimchuk, Z., Grant, S.R., Dangl, J.K., Sondek, J.
Deposit date:2004-01-07
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
1S28
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CRYSTAL STRUCTURE OF AVRPPHF ORF1, THE CHAPERONE FOR THE TYPE III EFFECTOR AVRPPHF ORF2 FROM P. SYRINGAE
Descriptor:ORF1, SULFATE ION
Authors:Singer, A.U., Desveaux, D., Betts, L., Chang, J.H., Nimchuk, Z., Grant, S.R., Dangl, J.L., Sondek, J.
Deposit date:2004-01-08
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
1XO5
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CRYSTAL STRUCTURE OF CIB1, AN EF-HAND, INTEGRIN AND KINASE-BINDING PROTEIN
Descriptor:Calcium and integrin-binding protein 1, CALCIUM ION
Authors:Gentry, H.R., Singer, A.U., Betts, L., Yang, C., Ferrara, J.D., Parise, L.V., Sondek, J.
Deposit date:2004-10-05
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins
J.Biol.Chem., 280, 2005
1Y3A
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STRUCTURE OF G-ALPHA-I1 BOUND TO A GDP-SELECTIVE PEPTIDE PROVIDES INSIGHT INTO GUANINE NUCLEOTIDE EXCHANGE
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, KB752 peptide, ...
Authors:Johnston, C.A., Willard, F.S., Jezyk, M.R., Fredericks, Z., Bodor, E.T., Jones, M.B., Blaesius, R., Harden, T.K., Sondek, J., Watts, V.J., Ramer, J.K., Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
2FJU
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ACTIVATED RAC1 BOUND TO ITS EFFECTOR PHOSPHOLIPASE C BETA 2
Descriptor:Ras-related C3 botulinum toxin substrate 1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, MAGNESIUM ION, ...
Authors:Jezyk, M.R., Snyder, J.T., Harden, T.K., Sondek, J.
Deposit date:2006-01-03
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nat.Struct.Mol.Biol., 13, 2006
2NUD
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THE STRUCTURE OF THE TYPE III EFFECTOR AVRB COMPLEXED WITH A HIGH-AFFINITY RIN4 PEPTIDE
Descriptor:Avirulence B protein, RPM1-interacting protein 4, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Singer, A.U., Desveaux, D., Wu, A.J., McNulty, B., Sondek, J., Dangl, J.L.
Deposit date:2006-11-09
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.
Plos Pathog., 3, 2007
2NUN
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THE STRUCTURE OF THE TYPE III EFFECTOR AVRB COMPLEXED WITH ADP
Descriptor:Avirulence B protein, ADENOSINE-5'-DIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Singer, A.U., Desveaux, D., Wu, A.J., McNulty, B., Dangl, J.L., Sondek, J.
Deposit date:2006-11-09
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.
Plos Pathog., 3, 2007
2NZ8
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N-TERMINAL DHPH CASSETTE OF TRIO IN COMPLEX WITH NUCLEOTIDE-FREE RAC1
Descriptor:ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
Authors:Chhatriwala, M.K., Betts, L., Worthylake, D.K., Sondek, J.
Deposit date:2006-11-22
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
2PBI
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THE MULTIFUNCTIONAL NATURE OF GBETA5/RGS9 REVEALED FROM ITS CRYSTAL STRUCTURE
Descriptor:Regulator of G-protein signaling 9, Guanine nucleotide-binding protein subunit beta 5, GLYCEROL
Authors:Cheever, M.L., Snyder, J.T., Gershburg, S., Siderovski, D.P., Harden, T.K., Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
2PZ1
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CRYSTAL STRUCTURE OF AUTO-INHIBITED ASEF
Descriptor:Rho guanine nucleotide exchange factor 4
Authors:Betts, L., Sondek, J., Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
3OHM
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CRYSTAL STRUCTURE OF ACTIVATED G ALPHA Q BOUND TO ITS EFFECTOR PHOSPHOLIPASE C BETA 3
Descriptor:Guanine nucleotide-binding protein G(q) subunit alpha, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Waldo, G.L., Sondek, J., Harden, T.K.
Deposit date:2010-08-17
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex.
Science, 330, 2010
4K44
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AUTO-INHIBITION AND PHOSPHORYLATION-INDUCED ACTIVATION OF PLC-GAMMA ISOZYMES
Descriptor:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Authors:Hajicek, N., Sondek, J.
Deposit date:2013-04-11
Release date:2013-06-26
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes.
Biochemistry, 52, 2013
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