Author results

4CO8
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STRUCTURE OF THE DNA BINDING ETS DOMAIN OF HUMAN ETV4
Descriptor:ETS TRANSLOCATION VARIANT 4, 1,2-ETHANEDIOL
Authors:Newman, J.A., Cooper, C.D.O., Shrestha, L., Burgess-Brown, N., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
Deposit date:2014-01-27
Release date:2014-02-05
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
6QNV
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FIBRINOGEN-LIKE GLOBE DOMAIN OF HUMAN TENASCIN-C
Descriptor:Tenascin
Authors:Coker, J.A., Bezerra, G.A., Bradshaw, W.J., Zhang, M., Yosaatmadja, Y., Fernandez-Cid, A., Shrestha, L., Burgess-Brown, N., Gileadi, O., Arrowsmith, C.H., Bountra, C., Midwood, K.S., Yue, W.W., Marsden, B.D., Structural Genomics Consortium (SGC)
Deposit date:2019-02-12
Release date:2019-02-27
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fibrinogen-like globe domain of Human Tenascin-C
To Be Published
4C45
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CRYSTAL STRUCTURE OF HUMAN PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2 (PCBD2)
Descriptor:PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2, 1,2-ETHANEDIOL
Authors:Kopec, J., Kiyani, W., Vollmar, M., Shrestha, L., Canning, P., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
Deposit date:2013-08-30
Release date:2013-09-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure of Human Pterin-4-Alpha- Carbinolamine Dehydratase 2 (Pcbd2)
To be Published
5LF9
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CRYSTAL STRUCTURE OF HUMAN NUDT22
Descriptor:Nucleoside diphosphate-linked moiety X motif 22
Authors:Tallant, C., Siejka, P., Mathea, S., Shrestha, L., Krojer, T., Srikannathasan, V., Elkins, J.M., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Huber, K., Structural Genomics Consortium (SGC)
Deposit date:2016-06-30
Release date:2017-08-02
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human NUDT22
To Be Published
5AK7
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STRUCTURE OF WT PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE
Descriptor:PEPTIDYLARGININE DEIMINASE, ALANINE, ARGININE, ...
Authors:Kopec, J., Montgomery, A., Shrestha, L., Kiyani, W., Nowak, R., Burgess-Brown, N., Venables, P.J., Yue, W.W.
Deposit date:2015-03-02
Release date:2015-07-22
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal Structure of Porphyromonas Gingivalis Peptidylarginine Deiminase: Implications for Autoimmunity in Rheumatoid Arthritis.
Ann.Rheum.Dis., 75, 2016
3ZYQ
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CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OF HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE (HGS-HRS) AT 1.48 A RESOLUTION
Descriptor:HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE, ZINC ION, SULFATE ION, ...
Authors:Muniz, J.R.C., Ayinampudi, V., Shrestha, L., Krojer, T., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bullock, A.
Deposit date:2011-08-24
Release date:2011-09-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of the Tandem Vhs and Fyve Domains of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) at 1.48 A Resolution
To be Published
5AK8
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STRUCTURE OF C351A MUTANT OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE
Descriptor:PEPTIDYLARGININE DEIMINASE, ALANINE, ARGININE, ...
Authors:Kopec, J., Montgomery, A., Shrestha, L., Kiyani, W., Nowak, R., Burgess-Brown, N., Venables, P.J., Yue, W.W.
Deposit date:2015-03-02
Release date:2015-07-22
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of Porphyromonas Gingivalis Peptidylarginine Deiminase: Implications for Autoimmunity in Rheumatoid Arthritis.
Ann.Rheum.Dis., 75, 2016
2OVJ
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THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATING PROTEIN 1 (RACGAP1) MGCRACGAP.
Descriptor:Rac GTPase-activating protein 1, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Shrestha, L., Papagrigoriou, E., Soundararajan, M., Elkins, J., Johansson, C., von Delft, F., Pike, A.C.W., Burgess, N., Turnbull, A., Debreczeni, J., Gorrec, F., Umeano, C., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-02-14
Release date:2007-02-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP.
To be Published
2UZC
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STRUCTURE OF HUMAN PDLIM5 IN COMPLEX WITH THE C-TERMINAL PEPTIDE OF HUMAN ALPHA-ACTININ-1
Descriptor:PDZ AND LIM DOMAIN 5, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Bunkoczi, G., Elkins, J., Salah, E., Burgess-Brown, N., Papagrigoriou, E., Pike, A.C.W., Turnbull, A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Doyle, D.
Deposit date:2007-04-27
Release date:2007-05-08
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Protein Sci., 19, 2010
6I8Y
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CRYSTAL STRUCTURE OF SPINDLIN1 IN COMPLEX WITH THE METHYLTRANSFERASE INHIBITOR A366
Descriptor:Spindlin-1, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, 1,2-ETHANEDIOL, ...
Authors:Srikannathasan, V., Johansson, C., Gileadi, C., Shrestha, L., Sorrell, F.J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.C.T.
Deposit date:2018-11-21
Release date:2018-12-26
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366
To Be Published
4A60
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CRYSTAL STRUCTURE OF HUMAN TESTIS-SPECIFIC FATTY ACID BINDING PROTEIN 9 (FABP9)
Descriptor:FATTY ACID-BINDING PROTEIN 9 TESTIS LIPID-BINDING PROTEIN, TLBP, TESTIS-TYPE FATTY ACID-BINDING PROTEIN, ...
Authors:Muniz, J.R.C., Kiyani, W., Shrestha, L., Froese, D.S., Krojer, T., Vollmar, M., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., von Delft, F., Yue, W.W.
Deposit date:2011-10-31
Release date:2011-11-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The Crystal Structure of the Human Fabp9A
To be Published
5AIL
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HUMAN PARP9 2ND MACRODOMAIN
Descriptor:POLY [ADP-RIBOSE] POLYMERASE 9, 1,2-ETHANEDIOL, POLYETHYLENE GLYCOL (N=34), ...
Authors:Sieg, C., Shrestha, L., Talon, R., Sorrell, F., Williams, E., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
Deposit date:2015-02-15
Release date:2015-02-25
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of Parp9 2Nd Macrodomain
To be Published
5LZK
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STRUCTURE OF THE DOMAIN OF UNKNOWN FUNCTION DUF1669 FROM HUMAN FAM83B
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Bufton, J.C., Williams, E.P., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2016-09-29
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.575 Å)
Cite:Structure of the domain of unknown function DUF1669 from human FAM83B
To Be Published
2W7R
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN MICROTUBULE ASSOCIATED SERINE- THREONINE KINASE 4
Descriptor:MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 4, PHOSPHATE ION
Authors:Muniz, J.R.C., Elkins, J., Wang, J., Savitzky, P., Roos, A., Salah, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2008-12-24
Release date:2009-05-12
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unusual Binding Interactions in Pdz Domain Crystal Structures Help Explain Binding Mechanisms.
Protein Sci., 19, 2010
4B4C
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CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.
Descriptor:CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Allerston, C.K., Cooper, C.D.O., Shrestha, L., Vollmar, M., Burgess-Brown, N., Yue, W.W., Carpenter, E.P., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-07-30
Release date:2012-08-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal Structure of the DNA-Binding Domain of Human Chd1.
To be Published
6H00
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CRYSTAL STRUCTURE OF HUMAN PYRIDOXINE 5-PHOPHATE OXIDASE, R116Q VARIANT
Descriptor:Pyridoxine-5'-phosphate oxidase, SULFATE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Mackinnon, S., Wilson, M.P., Shrestha, L., Bezerra, G.A., Newman, J., Fox, N., Sorrell, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Clayton, P.T., Mills, P.B., Yue, W.W.
Deposit date:2018-07-05
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structure of human pyridoxine 5-phophate oxidase, R116Q variant
To Be Published
4AVX
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HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 A RESOLUTION
Descriptor:HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE, 1,2-ETHANEDIOL, ZINC ION, ...
Authors:Williams, E., Canning, P., Shrestha, L., Krojer, T., Vollmar, M., Slowey, A., Conway, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bullock, A.
Deposit date:2012-05-30
Release date:2012-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal Structure of the Tandem Vhs and Fyve Domains of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) Bound to an Ip2 Compound at 1.68 A Resolution
To be Published
2JAM
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G, POLYPEPTIDE, 1,2-ETHANEDIOL, ...
Authors:Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
To be Published
2PA1
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM2 BOUND TO A C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN
Descriptor:PDZ and LIM domain protein 2, CHLORIDE ION
Authors:Uppenberg, J., Shrestha, L., Elkins, J., Burgess-Brown, N., Salah, E., Bunkoczi, G., Papagrigoriou, E., Pike, A.C.W., Turnbull, A.P., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin.
To be Published
5LUG
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN-2B PROTEIN IN COMPLEX WITH ART(M3L)QTA(2MR)KS PEPTIDE
Descriptor:Spindlin-like protein 2, isoform CRA_a, ALA-ARG-THR-M3L-GLN-THR-ALA-2MR-LYS-SER, ...
Authors:Srikannathasan, V., Gileadi, C., Talon, R., Shrestha, L., Kopec, J., Szykowska, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Oppermann, U., Huber, K.
Deposit date:2016-09-08
Release date:2017-09-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide
To be published
5IN3
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CRYSTAL STRUCTURE OF GLUCOSE-1-PHOSPHATE BOUND NUCLEOTIDYLATED HUMAN GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
Descriptor:Galactose-1-phosphate uridylyltransferase, ZINC ION, 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, ...
Authors:Kopec, J., McCorvie, T., Tallant, C., Velupillai, S., Shrestha, L., Fitzpatrick, F., Patel, D., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-03-07
Release date:2016-03-30
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
Hum.Mol.Genet., 25, 2016
4AZ9
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CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTING NEXIN 24
Descriptor:SORTING NEXIN-24, 1,2-ETHANEDIOL
Authors:Oberholzer, A.E., Kiyani, W., Krojer, T., Shrestha, L., von Delft, F., Froese, D.S., Chaikuad, A., Raynor, J., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2012-06-24
Release date:2012-10-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Phox Homology Domain of Human Sorting Nexin 24
To be Published
4TLG
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CRYSTAL STRUCTURE OF SEC14-LIKE PROTEIN 4 (SEC14L4)
Descriptor:SEC14-like protein 4, 1,2-ETHANEDIOL, UNDECANOIC ACID
Authors:Vollmar, M., Kopec, J., Kiyani, W., Shrestha, L., Sorrell, F., Krojer, T., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-05-29
Release date:2014-07-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of SEC14-like protein 4 (SEC14L4)
To Be Published
3ZLI
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CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY
Descriptor:HISTONE DEMETHYLASE UTY, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ...
Authors:Vollmar, M., Gileadi, C., Shrestha, L., Goubin, S., Johansson, C., Krojer, T., Raynor, J.W., Bradley, A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2013-01-31
Release date:2013-02-27
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Uty(Kdm6C) is a Male-Specific Nepsilon-Methyl Lysyl Demethylase.
J.Biol.Chem., 289, 2014
4V24
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SPHINGOSINE KINASE 1 IN COMPLEX WITH PF-543
Descriptor:SPHINGOSINE KINASE 1, {(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL, ACETATE ION
Authors:Elkins, J.M., Wang, J., Sorrell, F., Tallant, C., Wang, D., Shrestha, L., Bountra, C., von Delft, F., Knapp, S., Edwards, A.
Deposit date:2014-10-05
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Sphingosine Kinase 1 with Pf-543.
Acs Med.Chem.Lett., 5, 2014