5IN3

Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase

Summary for 5IN3

Entry DOI	10.2210/pdb5in3/pdb
Descriptor	Galactose-1-phosphate uridylyltransferase, ZINC ION, 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, ... (6 entities in total)
Functional Keywords	galt, ump-galt, glucose-1-phosphate, galactose-1-phosphate uridylyltransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	94994.99
Authors	Kopec, J.,McCorvie, T.,Tallant, C.,Velupillai, S.,Shrestha, L.,Fitzpatrick, F.,Patel, D.,Chalk, R.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Yue, W.W. (deposition date: 2016-03-07, release date: 2016-03-30, Last modification date: 2024-01-10)
Primary citation	McCorvie, T.J.,Kopec, J.,Pey, A.L.,Fitzpatrick, F.,Patel, D.,Chalk, R.,Shrestha, L.,Yue, W.W. Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase. Hum.Mol.Genet., 25:2234-2244, 2016 Cited by PubMed: 27005423 DOI: 10.1093/hmg/ddw091 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation