5IN3

Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Galactose-1-phosphate uridylyltransferase	polymer	401	45976.8	2	UniProt (P07902) Pfam (PF01087) Pfam (PF02744) In PDB	Homo sapiens (Human)	Gal-1-P uridylyltransferase,UDP-glucose--hexose-1-phosphate uridylyltransferase
2	B, A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	B, A	5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE	non-polymer		326.2	2	Chemie (H2U)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	28	Chemie (EDO)
5	A, B	1-O-phosphono-alpha-D-glucopyranose	non-polymer		260.1	2	Chemie (G1P)
6		water	water		18.0	424	Chemie (HOH)

Sequence modifications

B, A: 1 - 379 (UniProt: P07902)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	91953.6
Non-Polymers*	Number of molecules	34
	Total formula weight	3041.4
All*	Total formula weight	94995.0

*Water molecules are not included.