Author results

5H23
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CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS CAPSID PROTEIN
Descriptor:Capsid Protein, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sharma, R., Kesari, P., Tomar, S., Kumar, P.
Deposit date:2016-10-14
Release date:2018-03-14
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket.
Virology, 515, 2018
2MYI
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SOLUTION STRUCTURE OF CRC FROM P. SYRINGAE LZ4W
Descriptor:Exodeoxyribonuclease III
Authors:Deshmukh, M.V., Sharma, R.
Deposit date:2015-01-25
Release date:2016-01-27
Method:SOLUTION NMR
Cite:Crc binds RNA independent of Hfq
To be Published
5FTW
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CRYSTAL STRUCTURE OF GLUTAMATE O-METHYLTRANSFERASE IN COMPLEX WITH S- ADENOSYL-L-HOMOCYSTEINE (SAH) FROM BACILLUS SUBTILIS
Descriptor:CHEMOTAXIS PROTEIN METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Sharma, R., Dhindwal, S., Batra, M., Aggarwal, M., Kumar, P., Tomar, S.
Deposit date:2016-01-18
Release date:2016-10-05
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Pentapeptide-Independent Chemotaxis Receptor Methyltransferase (Cher) Reveals Idiosyncratic Structural Determinants for Receptor Recognition.
J.Struct.Biol., 196, 2016
3NOE
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CRYSTAL STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:Dihydrodipicolinate synthase, S-1,2-PROPANEDIOL
Authors:Kaur, N., Kumar, S., Singh, N., Gautam, A., Sharma, R., Sharma, S., Tewari, R., Singh, T.P.
Deposit date:2010-06-25
Release date:2010-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal Structure of Dihydrodipicolinate synthase from Pseudomonas aeruginosa
To be Published
3PS7
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BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURE DETERMINATION OF DIHYDRODIPICOLINATE SYNTHASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:Dihydrodipicolinate synthase, S-1,2-PROPANEDIOL
Authors:Kaur, N., Gautam, A., Kumar, S., Singh, A., Singh, N., Sharma, S., Sharma, R., Tewari, R., Singh, T.P.
Deposit date:2010-12-01
Release date:2010-12-15
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Biochemical studies and crystal structure determination of dihydrodipicolinate synthase from Pseudomonas aeruginosa
Int.J.Biol.Macromol., 48, 2011
3PUO
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CRYSTAL STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE FROM PSEUDOMONAS AERUGINOSA(PSDHDPS)COMPLEXED WITH L-LYSINE AT 2.65A RESOLUTION
Descriptor:Dihydrodipicolinate synthase, LYSINE, GLYCEROL
Authors:Kaur, N., Kumar, M., Kumar, S., Gautam, A., Sinha, M., Kaur, P., Sharma, S., Sharma, R., Tewari, R., Singh, T.P.
Deposit date:2010-12-06
Release date:2010-12-29
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Biochemical studies and crystal structure determination of dihydrodipicolinate synthase from Pseudomonas aeruginosa
Int.J.Biol.Macromol., 48, 2011
1YNY
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MOLECULAR STRUCTURE OF D-HYDANTOINASE FROM A BACILLUS SP. AR9: EVIDENCE FOR MERCURY INHIBITION
Descriptor:D-Hydantoinase, MANGANESE (II) ION
Authors:Radha Kishan, K.V., Vohra, R.M., Ganeshan, K., Agrawal, V., Sharma, V.M., Sharma, R.
Deposit date:2005-01-26
Release date:2005-03-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular structure of D-hydantoinase from Bacillus sp. AR9: evidence for mercury inhibition.
J.Mol.Biol., 347, 2005
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4LS9
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STRUCTURE OF MYCOBACTERIAL NRNA HOMOLOG REVEALS MULTIFUNCTIONAL NUCLEASE ACTIVITIES
Descriptor:DHH family protein, MANGANESE (II) ION, GLYCEROL
Authors:Kumar, D., Srivastav, R., Grover, A., Manjasetty, B.A., Sharma, R., Taneja, B.
Deposit date:2013-07-22
Release date:2014-07-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases
Nucleic Acids Res., 42, 2014
2JWG
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STRUCTURE OF A GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED DOMAIN FROM A TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN
Descriptor:Variant surface glycoprotein ILTAT 1.24
Authors:Jones, N.G., Nietlispach, D., Sharma, R., Burke, D.F., Eyres, I., Mues, M., Mott, H.R., Carrington, M.
Deposit date:2007-10-12
Release date:2007-11-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
J.Biol.Chem., 283, 2008
2JWH
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STRUCTURE OF A GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED DOMAIN FROM A TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN
Descriptor:Variant surface glycoprotein ILTAT 1.24
Authors:Jones, N.G., Nietlispach, D., Sharma, R., Burke, D.F., Eyres, I., Mues, M., Mott, H.R., Carrington, M.
Deposit date:2007-10-12
Release date:2007-11-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
J.Biol.Chem., 283, 2008
4A7G
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STRUCTURE OF HUMAN I113T SOD1 MUTANT COMPLEXED WITH 4-METHYLPIPERAZIN- 1-YL)QUINAZOLINE IN THE P21 SPACE GROUP.
Descriptor:SUPEROXIDE DISMUTASE [CU-ZN], SULFATE ION, 4-(4-METHYLPIPERAZIN-1-YL)QUINAZOLINE, ...
Authors:Wright, G.S.A., Kershaw, N.M., Sharma, R., Antonyuk, S.V., Strange, R.W., Berry, N.G., O'Neil, P.M., Hasnain, S.S.
Deposit date:2011-11-14
Release date:2012-10-24
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:X-ray crystallography and computational docking for the detection and development of protein-ligand interactions.
Curr. Med. Chem., 20, 2013
5XQL
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CRYSTAL STRUCTURE OF A PSEUDOMONAS AERUGINOSA TRANSCRIPTIONAL REGULATOR
Descriptor:Multidrug-efflux transporter 1 regulator, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Raju, H., Sharma, R.
Deposit date:2017-06-07
Release date:2017-06-28
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Crystal structure of BrlR with c-di-GMP
Biochem. Biophys. Res. Commun., 490, 2017
6BNH
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SOLUTION NMR STRUCTURES OF BRD4 ET DOMAIN WITH JMJD6 PEPTIDE
Descriptor:Bromodomain-containing protein 4, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Authors:Konuma, T., Yu, D., Zhao, C., Ju, Y., Sharma, R., Ren, C., Zhang, Q., Zhou, M.-M., Zeng, L.
Deposit date:2017-11-16
Release date:2017-12-20
Method:SOLUTION NMR
Cite:Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.
Sci Rep, 7, 2017
5YBC
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X-RAY STRUCTURE OF NATIVE ETS-DOMAIN DOMAIN OF ERGP55
Descriptor:Transcriptional regulator ERG, GLYCEROL
Authors:Saxena, A.K., Gangwar, S.P.
Deposit date:2017-09-04
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence
Acta Crystallogr F Struct Biol Commun, 74, 2018
5YBD
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X-RAY STRUCTURE OF ETS DOMAIN OF ERGP55 IN COMPLEX WITH E74DNA
Descriptor:Transcriptional regulator ERG, DNA (5'-D(P*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3')
Authors:Saxena, A.K., Gangwar, S.P.
Deposit date:2017-09-04
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.769 Å)
Cite:Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence
Acta Crystallogr F Struct Biol Commun, 74, 2018
5E0N
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CRYSTAL STRUCTURE OF MSMEG_3139, A MONOFUNCTIONAL ENOYL COA ISOMERASE FROM M.SMEGMATIS
Descriptor:Enoyl-CoA hydratase/isomerase
Authors:Priyadarshan, K., Haque, A.S., Anandakrishnan, M., Sankaranarayanan, R.
Deposit date:2015-09-29
Release date:2016-02-03
Method:X-RAY DIFFRACTION (2.061 Å)
Cite:Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.
Chem.Biol., 22, 2015
5YC9
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CRYSTAL STRUCTURE OF A PSEUDOMONAS AERUGINOSA TRANSCRIPTIONAL REGULATOR
Descriptor:C-di-GMP-binding multidrug transporter transcriptional regulator BrlR
Authors:Harikiran, R., Rohan, S.
Deposit date:2017-09-07
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a Pseudomonas aeruginosa transcriptional regulator
To Be Published
3O0J
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PDE4B IN COMPLEX WITH LIGAND AN2898
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Alley, M.R.K., Zhou, Y.
Deposit date:2010-07-19
Release date:2011-08-10
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
Febs Lett., 586, 2012
4Z0M
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ECHA5 MYCOBACTERIUM TUBERCULOSIS
Descriptor:Enoyl-CoA hydratase
Authors:Chaudhary, S., Gokhale, R.S.
Deposit date:2015-03-26
Release date:2016-02-03
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase
Chem.Biol., 22, 2015
2Q1J
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THE DISCOVERY OF GLYCINE AND RELATED AMINO ACID-BASED FACTOR XA INHIBITORS
Descriptor:Activated factor Xa heavy chain (EC 3.4.21.6), Factor X light chain (EC 3.4.21.6), CALCIUM ION, ...
Authors:Kohrt, J.T., Filipski, K.J., Cody, W.L., Bigge, C.F., Zhang, E., Finzel, B.C.
Deposit date:2007-05-24
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Discovery of Glycine and Related Amino Acid-Based Factor Xa Inhibitors
BIOORG.MED.CHEM., 14, 2006
3GI3
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CRYSTAL STRUCTURE OF A N-PHENYL-N'-NAPHTHYLUREA ANALOG IN COMPLEX WITH P38 MAP KINASE
Descriptor:Mitogen-activated protein kinase 14, N-{5-tert-butyl-2-methoxy-3-[({4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl}carbamoyl)amino]phenyl}methanesulfonamide
Authors:Qian, K.C.
Deposit date:2009-03-05
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3OTQ
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SOLUBLE EPOXIDE HYDROLASE IN COMPLEX WITH PYRAZOLE ANTAGONIST
Descriptor:Epoxide hydrolase 2, N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide
Authors:Farrow, N.A.
Deposit date:2010-09-13
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.
Bioorg.Med.Chem.Lett., 20, 2010
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