Author results

1GUL
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HUMAN GLUTATHIONE TRANSFERASE A4-4 COMPLEX WITH IODOBENZYL GLUTATHIONE
Descriptor:GLUTATHIONE TRANSFERASE A4-4, S-(2-iodobenzyl) glutathione
Authors:Bruns, C.M., Hubatsch, I., Ridderstrom, M., Mannervik, B., Tainer, J.A.
Deposit date:1998-06-10
Release date:1999-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products
J.Mol.Biol., 288, 1999
1GUM
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HUMAN GLUTATHIONE TRANSFERASE A4-4 WITHOUT LIGANDS
Descriptor:PROTEIN (GLUTATHIONE TRANSFERASE A4-4)
Authors:Bruns, C.M., Hubatsch, I., Ridderstrom, M., Mannervik, B., Tainer, J.A.
Deposit date:1998-06-11
Release date:1999-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products
J.Mol.Biol., 288, 1999
4BV5
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), 4-(aminomethyl)-N-(benzenesulfonyl)cyclohexanecarboxamide
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BV7
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), ACETATE ION, 3-(4-piperidyl)propanoic acid
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVC
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), CHLORIDE ION, 3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE, ...
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVD
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), CHLORIDE ION, 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVV
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, SULFATE ION
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-28
Release date:2014-07-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVW
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), CHLORIDE ION, 1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid, ...
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-28
Release date:2014-07-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
1QH3
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HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE
Descriptor:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, CACODYLATE ION, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-05-10
Release date:1999-09-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QH5
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HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE
Descriptor:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, GLUTATHIONE, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-05-11
Release date:1999-09-24
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QIN
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HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE
Descriptor:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1QIP
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HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE
Descriptor:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1BH5
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HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT
Descriptor:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-HEXYLGLUTATHIONE
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1998-06-13
Release date:1998-11-04
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
J.Biol.Chem., 273, 1998
1FRO
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HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR
Descriptor:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-BENZYL-GLUTATHIONE
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1997-02-25
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
EMBO J., 16, 1997