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4PGZ
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STRUCTURAL BASIS OF KIT ACTIVATION BY ONCOGENIC MUTATIONS IN THE EXTRACELLULAR REGION REVEALS A ZIPPER-LIKE MECHANISM FOR LIGAND-DEPENDENT OR ONCOGENIC RECEPTOR TYROSINE KINASE ACTIVATION
Descriptor:Mast/stem cell growth factor receptor Kit, N-ACETYL-D-GLUCOSAMINE, COBALT (II) ION
Authors:Reshetnyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.
Deposit date:2014-05-03
Release date:2015-03-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015
4K94
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CRYSTAL STRUCTURE OF KIT D4D5 FRAGMENT IN COMPLEX WITH ANTI-KIT ANTIBODY FAB19
Descriptor:Fab19 heavy chain, Fab19 light chain, Mast/stem cell growth factor receptor Kit, ...
Authors:Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
4K9E
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CRYSTAL STRUCTURE OF KIT D4D5 FRAGMENT IN COMPLEX WITH ANTI-KIT ANTIBODIES FAB79D
Descriptor:light chain, heavy chain, Mast/stem cell growth factor receptor Kit, ...
Authors:Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013