Author results

1E7D
  • Download 1e7d
  • View 1e7d
Molmil generated image of 1e7d
ENDONUCLEASE VII (ENDOVII) FFROM PHAGE T4
Descriptor:RECOMBINATION ENDONUCLEASE VII, ZINC ION, CALCIUM ION, ...
Authors:Raaijmakers, H.C.A., Vix, O., Toro, I., Suck, D.
Deposit date:2000-08-28
Release date:2001-05-04
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational Flexibility in T4 Endonuclease Vii Revealed by Crystallography: Implications for Substrate Binding and Cleavage
J.Mol.Biol., 308, 2001
1E7L
  • Download 1e7l
  • View 1e7l
Molmil generated image of 1e7l
ENDONUCLEASE VII (ENDOVII) N62D MUTANT FROM PHAGE T4
Descriptor:RECOMBINATION ENDONUCLEASE VII, SULFATE ION, ZINC ION
Authors:Raaijmakers, H.C.A., Vix, O., Toro, I., Suck, D.
Deposit date:2000-08-29
Release date:2001-05-04
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Conformational Flexibility in T4 Endonuclease Vii Revealed by Crystallography: Implications for Substrate Binding and Cleavage
J.Mol.Biol., 308, 2001
1H0H
  • Download 1h0h
  • View 1h0h
Molmil generated image of 1h0h
TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS
Descriptor:FORMATE DEHYDROGENASE SUBUNIT ALPHA, FORMATE DEHYDROGENASE SUBUNIT BETA, TUNGSTEN ION, ...
Authors:Raaijmakers, H.C.A.
Deposit date:2002-06-19
Release date:2003-02-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Gene Sequence and the 1.8 A Crystal Structure of the Tungsten-Containing Formate Dehydrogenase from Desulfovibrio Gigas
Structure, 10, 2002
2IV2
  • Download 2iv2
  • View 2iv2
Molmil generated image of 2iv2
REINTERPRETATION OF REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI
Descriptor:Formate dehydrogenase H, IRON/SULFUR CLUSTER, GUANYLATE-O'-PHOSPHORIC ACID MONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,5,6,7,8A,9,10,10A-OCTAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL) ESTER, ...
Authors:Raaijmakers, H.C.A., Romao, M.J.
Deposit date:2006-06-08
Release date:2006-06-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Formate-Reduced E. Coli Formate Dehydrogenase H: The Reinterpretation of the Crystal Structure Suggests a New Reaction Mechanism.
J.Biol.Inorg.Chem., 11, 2006
2W8Y
  • Download 2w8y
  • View 2w8y
Molmil generated image of 2w8y
RU486 BOUND TO THE PROGESTERONE RECEPTOR IN A DESTABILIZED AGONISTIC CONFORMATION
Descriptor:PROGESTERONE RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, SULFATE ION, ...
Authors:Raaijmakers, H.C.A., Versteeg, J., Uitdehaag, J.C.M.
Deposit date:2009-01-20
Release date:2009-04-28
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
J.Biol.Chem., 284, 2009
5FBN
  • Download 5fbn
  • View 5fbn
Molmil generated image of 5fbn
BTK KINASE DOMAIN WITH INHIBITOR 1
Descriptor:Tyrosine-protein kinase BTK, 4-[8-azanyl-3-[(3~{R})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide, 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, ...
Authors:Raaijmakers, H.C.A., Vu-Pham, D.
Deposit date:2015-12-14
Release date:2016-02-03
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
Acs Med.Chem.Lett., 7, 2016
2A73
  • Download 2a73
  • View 2a73
Molmil generated image of 2a73
HUMAN COMPLEMENT COMPONENT C3
Descriptor:Complement C3, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A74
  • Download 2a74
  • View 2a74
Molmil generated image of 2a74
HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Complement Component C3c, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, GLYCEROL, ...
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2I6Q
  • Download 2i6q
  • View 2i6q
Molmil generated image of 2i6q
COMPLEMENT COMPONENT C2A
Descriptor:Complement C2a fragment, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Milder, F.J., Raaijmakers, H.C.A., Vandeputte, D.A.A., Schouten, A., Huizinga, E.G., Romijn, R.A., Hemrika, W., Roos, A., Daha, M.R., Gros, P.
Deposit date:2006-08-29
Release date:2006-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure, 14, 2006
2I6S
  • Download 2i6s
  • View 2i6s
Molmil generated image of 2i6s
COMPLEMENT COMPONENT C2A
Descriptor:Complement C2a fragment, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Milder, F.J., Raaijmakers, H.C.A., Vandeputte, D.A.A., Schouten, A., Huizinga, E.G., Romijn, R.A., Hemrika, W., Roos, A., Daha, M.R., Gros, P.
Deposit date:2006-08-29
Release date:2006-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure, 14, 2006
3ZR7
  • Download 3zr7
  • View 3zr7
Molmil generated image of 3zr7
STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS
Descriptor:PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, GLYCEROL, ...
Authors:Lusher, S.J., Raaijmakers, H.C.A., Vu-Pham, D., Dechering, K., Wai Lam, T., Brown, A.R., Hamilton, N.M., Nimz, O., Azevedo, R., McGuire, R., Oubrie, A., de Vlieg, J.
Deposit date:2011-06-15
Release date:2011-08-17
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
J. Biol. Chem., 286, 2011
3ZRA
  • Download 3zra
  • View 3zra
Molmil generated image of 3zra
STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS
Descriptor:PROGESTERONE RECEPTOR, N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE, SULFATE ION
Authors:Lusher, S.J., Raaijmakers, H.C.A., Vu-Pham, D., Dechering, K., Wai Lam, T., Brown, A.R., Hamilton, N.M., Nimz, O., Azevedo, R., McGuire, R., Oubrie, A., de Vlieg, J.
Deposit date:2011-06-15
Release date:2011-08-17
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
J. Biol. Chem., 286, 2011
3ZRB
  • Download 3zrb
  • View 3zrb
Molmil generated image of 3zrb
STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS
Descriptor:PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, SULFATE ION, ...
Authors:Lusher, S.J., Raaijmakers, H.C.A., Vu-Pham, D., Dechering, K., Wai Lam, T., Brown, A.R., Hamilton, N.M., Nimz, O., Azevedo, R., Mcguire, R., Oubrie, A., de Vlieg, J.
Deposit date:2011-06-15
Release date:2011-08-17
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
J. Biol. Chem., 286, 2011
3ZS5
  • Download 3zs5
  • View 3zs5
Molmil generated image of 3zs5
STRUCTURAL BASIS FOR KINASE SELECTIVITY OF THREE CLINICAL P38ALPHA INHIBITORS
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, B-OCTYLGLUCOSIDE, ...
Authors:Azevedo, R., van Zeeland, M., Raaijmakers, H.C.A., Kazemier, B., Oubrie, A.
Deposit date:2011-06-23
Release date:2012-07-04
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors.
Acta Crystallogr. D Biol. Crystallogr., 68, 2012
4A2J
  • Download 4a2j
  • View 4a2j
Molmil generated image of 4a2j
PR X-RAY STRUCTURES IN AGONIST CONFORMATIONS REVEAL TWO DIFFERENT MECHANISMS FOR PARTIAL AGONISM IN 11BETA-SUBSTITUTED STEROIDS
Descriptor:PROGESTERONE RECEPTOR, 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, SULFATE ION
Authors:Lusher, S.J., Raaijmakers, H.C.A., Bosch, R., Vu-Pham, D., McGuire, R., Oubrie, A., de Vlieg, J.
Deposit date:2011-09-27
Release date:2012-04-04
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids.
J. Biol. Chem., 287, 2012
4APU
  • Download 4apu
  • View 4apu
Molmil generated image of 4apu
PR X-RAY STRUCTURES IN AGONIST CONFORMATIONS REVEAL TWO DIFFERENT MECHANISMS FOR PARTIAL AGONISM IN 11BETA-SUBSTITUTED STEROIDS
Descriptor:PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, SULFATE ION, ...
Authors:Lusher, S.J., Raaijmakers, H.C.A., Bosch, R., Vu-Pham, D., McGuire, R., Oubrie, A., de Vlieg, J.
Deposit date:2012-04-06
Release date:2012-04-25
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids.
J. Biol. Chem., 287, 2012