Author results

5GRS
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COMPLEX STRUCTURE OF THE FISSION YEAST SREBP-SCAP BINDING DOMAINS
Descriptor:Sterol regulatory element-binding protein cleavage-activating protein, Sterol regulatory element-binding protein 1
Authors:Gong, X., Qian, H.W., Wu, J.P., Yan, N.
Deposit date:2016-08-12
Release date:2016-12-14
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
6N7G
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CRYO-EM STRUCTURE OF TETRAMERIC PTCH1 IN COMPLEX WITH SHHNP (FORM I)
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-11-27
Release date:2019-05-29
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Cryo-EM structure of the 2:1 hPtch1-Shhp complex
To Be Published
6N7K
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CRYO-EM STRUCTURE OF TETRAMERIC PTCH1 IN COMPLEX WITH SHHNP (FORM II)
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-11-27
Release date:2019-05-29
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structure of the 2:1 hPtch1-Shhp complex
To Be Published
5XJY
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CRYO-EM STRUCTURE OF HUMAN ABCA1
Descriptor:ATP-binding cassette sub-family A member 1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Qian, H.W., Yan, N., Gong, X.
Deposit date:2017-05-04
Release date:2017-06-07
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the Human Lipid Exporter ABCA1.
Cell, 169, 2017
5GPD
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF SREBP FROM FISSION YEAST
Descriptor:Sterol regulatory element-binding protein 1
Authors:Gong, X., Qian, H.W., Wu, J.P., Yan, N.
Deposit date:2016-08-01
Release date:2016-11-23
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
5JNX
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THE 6.6 A CRYO-EM STRUCTURE OF THE FULL-LENGTH HUMAN NPC1 IN COMPLEX WITH THE CLEAVED GLYCOPROTEIN OF EBOLA VIRUS
Descriptor:Niemann-Pick C1 protein, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gong, X., Qian, H.W., Zhou, X.H., Wu, J.P., Wan, T., Shi, Y., Gao, F., Zhou, Q., Yan, N.
Deposit date:2016-05-01
Release date:2016-06-15
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (6.56 Å)
Cite:Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Cell, 165, 2016
6DMB
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CRYO-EM STRUCTURE OF HUMAN PTCH1
Descriptor:Protein patched homolog 1, N-ACETYL-D-GLUCOSAMINE, CHOLESTEROL HEMISUCCINATE
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-06-04
Release date:2018-07-11
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6DMO
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CRYO-EM STRUCTURE OF HUMAN PTCH1 WITH THREE MUTATIONS L282Q/T500F/P504L
Descriptor:Protein patched homolog 1, N-ACETYL-D-GLUCOSAMINE
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-06-05
Release date:2018-07-11
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6DMY
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CRYO-EM STRUCTURE OF HUMAN PTCH1 AND SHHN COMPLEX
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-06-05
Release date:2018-07-11
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6DS5
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CRYO EM STRUCTURE OF HUMAN SEIPIN
Descriptor:Seipin, N-ACETYL-D-GLUCOSAMINE
Authors:Yan, R.H., Qian, H.W., Yan, N., Yang, H.Y.
Deposit date:2018-06-13
Release date:2018-10-24
Last modified:2018-10-31
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Human SEIPIN Binds Anionic Phospholipids.
Dev. Cell, 47, 2018
6N7H
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CRYO-EM STRUCTURE OF THE 2:1 HPTCH1-SHHP COMPLEX
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-11-27
Release date:2019-05-29
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019
3JD8
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CRYO-EM STRUCTURE OF THE FULL-LENGTH HUMAN NPC1 AT 4.4 ANGSTROM
Descriptor:Niemann-Pick C1 protein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Gong, X., Qian, H.W., Zhou, X.H., Wu, J.P., Zhou, Q., Yan, N.
Deposit date:2016-05-01
Release date:2016-06-01
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.43 Å)
Cite:The structure of Niemann-Pick C1 protein
To Be Published