6W5V

NPC1-NPC2 complex structure at pH 5.5

Summary for 6W5V

Entry DOI	10.2210/pdb6w5v/pdb
EMDB information	21545 21546 21547 21548 21549
Descriptor	NPC intracellular cholesterol transporter 1, NPC intracellular cholesterol transporter 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	cholesterol lysosome, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	169672.48
Authors	Yan, N.,Qian, H.W.,Wu, X.L. (deposition date: 2020-03-13, release date: 2020-06-17, Last modification date: 2020-07-29)
Primary citation	Qian, H.,Wu, X.,Du, X.,Yao, X.,Zhao, X.,Lee, J.,Yang, H.,Yan, N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182:98-111.e18, 2020 Cited by PubMed: 32544384 DOI: 10.1016/j.cell.2020.05.020 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4 Å)

Structure validation