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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6W5V

NPC1-NPC2 complex structure at pH 5.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005319	molecular_function	lipid transporter activity
A	0016020	cellular_component	membrane
D	0015918	biological_process	sterol transport
D	0032367	biological_process	intracellular cholesterol transport
D	0032934	molecular_function	sterol binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9Z0J0

Chain	Residue	Details
D	LYS116

site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:17018531, ECO:0000269\|PubMed:27551080, ECO:0007744\|PDB:5KWY

Chain	Residue	Details
D	ASN58

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:17018531, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:27551080, ECO:0007744\|PDB:5KWY

Chain	Residue	Details
D	ASN135

site_id	SWS_FT_FI4
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:27238017, ECO:0000269\|PubMed:28784760

Chain	Residue	Details
A	GLY351-VAL371
A	VAL621-HIS641

site_id	SWS_FT_FI5
Number of Residues	248
Details	TOPO_DOM: Lumenal => ECO:0000269\|PubMed:27238017, ECO:0000269\|PubMed:28784760

Chain	Residue	Details
A	ARG372-ASP620

site_id	SWS_FT_FI6
Number of Residues	142
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:28784760

Chain	Residue	Details
A	MET642-LYS653
A	GLN707-GLU730
A	GLY784-ASP832
A	CYS1119-ALA1124
A	THR1172-MET1194
A	PRO1245-PHE1278

site_id	SWS_FT_FI7
Number of Residues	204
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:28784760

Chain	Residue	Details
A	VAL654-PHE675
A	PHE1224-LEU1244
A	VAL686-VAL706
A	VAL731-LEU751
A	PHE760-LEU783
A	TRP833-LEU853
A	THR1098-GLY1118
A	VAL1125-TRP1145
A	ALA1151-ILE1171
A	GLY1195-PHE1215

site_id	SWS_FT_FI8
Number of Residues	270
Details	TOPO_DOM: Lumenal => ECO:0000269\|PubMed:28784760

Chain	Residue	Details
A	SER676-ILE685
A	SER752-THR759
A	ASN854-ASP1097
A	GLY1146-ASN1150
A	ALA1216-ILE1223

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:19563754, ECO:0000305\|PubMed:27238017, ECO:0007744\|PDB:3GKI, ECO:0007744\|PDB:3GKJ

Chain	Residue	Details
A	ASN41
A	GLN79

site_id	SWS_FT_FI10
Number of Residues	1
Details	SITE: Important for cholesterol binding => ECO:0000269\|PubMed:19563754

Chain	Residue	Details
A	PHE108

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305\|PubMed:10821832

Chain	Residue	Details
A	ASN70

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:27238017, ECO:0000305\|PubMed:10821832, ECO:0007744\|PDB:3JD8

Chain	Residue	Details
A	ASN122
A	ASN185

site_id	SWS_FT_FI13
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:27238017, ECO:0007744\|PDB:3JD8

Chain	Residue	Details
A	ASN135

site_id	SWS_FT_FI14
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269\|PubMed:19563754, ECO:0000269\|PubMed:27238017, ECO:0007744\|PDB:3GKI, ECO:0007744\|PDB:3GKJ, ECO:0007744\|PDB:3JD8

Chain	Residue	Details
A	ASN158

site_id	SWS_FT_FI15
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19563754, ECO:0000269\|PubMed:27238017, ECO:0007744\|PDB:3GKI, ECO:0007744\|PDB:3GKJ, ECO:0007744\|PDB:3JD8

Chain	Residue	Details
A	ASN222

site_id	SWS_FT_FI16
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:28784760, ECO:0007744\|PDB:5U74

Chain	Residue	Details
A	ASN452
A	ASN459
A	ASN916
A	ASN931
A	ASN961
A	ASN968

site_id	SWS_FT_FI17
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:26846330, ECO:0000269\|PubMed:28784760, ECO:0007744\|PDB:5HNS, ECO:0007744\|PDB:5U74

Chain	Residue	Details
A	ASN478
A	ASN557

site_id	SWS_FT_FI18
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:26846330, ECO:0000269\|PubMed:27238017, ECO:0000269\|PubMed:28784760, ECO:0007744\|PDB:3JD8, ECO:0007744\|PDB:5HNS, ECO:0007744\|PDB:5U74

Chain	Residue	Details
A	ASN524

site_id	SWS_FT_FI19
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:26846330, ECO:0000269\|PubMed:27238017, ECO:0007744\|PDB:3JD8, ECO:0007744\|PDB:5HNS

Chain	Residue	Details
A	ASN572

site_id	SWS_FT_FI20
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:26846330, ECO:0000269\|PubMed:27238017, ECO:0000269\|PubMed:28784760, ECO:0007744\|PDB:3JD8, ECO:0007744\|PDB:5HNS, ECO:0007744\|PDB:5U74

Chain	Residue	Details
A	ASN598

site_id	SWS_FT_FI21
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:27238017, ECO:0000269\|PubMed:28784760, ECO:0007744\|PDB:3JD8, ECO:0007744\|PDB:5U74

Chain	Residue	Details
A	ASN1064

site_id	SWS_FT_FI22
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN1072

219515

PDB entries from 2024-05-08

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