6N7K
Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form II)
Summary for 6N7K
| Entry DOI | 10.2210/pdb6n7k/pdb |
| EMDB information | 0358 |
| Descriptor | Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
| Functional Keywords | receptor, rnd family, protein binding |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 650738.67 |
| Authors | Yan, N.,Gong, X.,Qian, H.W. (deposition date: 2018-11-27, release date: 2019-05-29, Last modification date: 2020-07-29) |
| Primary citation | Qian, H.,Cao, P.,Hu, M.,Gao, S.,Yan, N.,Gong, X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun, 10:2320-2320, 2019 Cited by PubMed: 31127104DOI: 10.1038/s41467-019-10234-9 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (6.5 Å) |
Structure validation
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