Author results

1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor:SAP SH2 DOMAIN, SULFATE ION
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1JPW
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CRYSTAL STRUCTURE OF A HUMAN TCF-4 / BETA-CATENIN COMPLEX
Descriptor:BETA-CATENIN, transcription factor 7-like 2
Authors:Poy, F., Lepourcelet, M., Shivdasani, R.A., Eck, M.J.
Deposit date:2001-08-03
Release date:2001-12-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a human Tcf4-beta-catenin complex.
Nat.Struct.Biol., 8, 2001
1I3Z
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MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Lu, J., Poy, F., Morra, M., Terhorst, C., Eck, M.J.
Deposit date:2001-02-19
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Eur.J.Biochem., 20, 2001
5I1Q
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SECOND BROMODOMAIN OF TAF1 BOUND TO A PYRROLOPYRIDONE COMPOUND
Descriptor:Transcription initiation factor TFIID subunit 1, 3-[6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl]-N,N-dimethylbenzamide
Authors:Tang, Y., Poy, F., Bellon, S.F.
Deposit date:2016-01-09
Release date:2016-06-08
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J.Med.Chem., 59, 2016
5I29
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TAF1(2) BOUND TO A PYRROLOPYRIDONE COMPOUND
Descriptor:Transcription initiation factor TFIID subunit 1, N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide, CALCIUM ION
Authors:Tang, Y., Poy, F., Bellon, S.F.
Deposit date:2016-02-08
Release date:2016-06-08
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J.Med.Chem., 59, 2016
5KR7
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KDM4C BOUND TO PYRAZOLO-PYRIMIDINE SCAFFOLD
Descriptor:Lysine-specific demethylase 4C, FE (II) ION, ZINC ION, ...
Authors:Bellon, S.F., Poy, F., Setser, J.W.
Deposit date:2016-07-07
Release date:2016-08-17
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of potent, selective KDM5 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5KTU
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO PYRAZOLOPIPERIDINE SCAFFOLD
Descriptor:CREB-binding protein, 1-(3-phenylazanyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone, DIMETHYL SULFOXIDE
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
1EG3
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STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE
Descriptor:DYSTROPHIN
Authors:Huang, X., Poy, F., Zhang, R., Joachimiak, A., Sudol, M., Eck, M.J.
Deposit date:2000-02-11
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nat.Struct.Biol., 7, 2000
1EG4
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STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE
Descriptor:BETA-DYSTROGLYCAN, DYSTROPHIN
Authors:Huang, X., Poy, F., Zhang, R., Joachimiak, A., Sudol, M., Eck, M.J.
Deposit date:2000-02-11
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nat.Struct.Biol., 7, 2000
1L3E
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NMR STRUCTURES OF THE HIF-1ALPHA CTAD/P300 CH1 COMPLEX
Descriptor:hypoxia inducible factor-1 alpha subunit, p300 protein, ZINC ION
Authors:Freedman, S.J., Sun, Z.J., Poy, F., Kung, A.L., Livingston, D.M., Wagner, G., Eck, M.J.
Deposit date:2002-02-26
Release date:2002-04-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proc.Natl.Acad.Sci.USA, 99, 2002
1LAR
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CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR
Descriptor:PROTEIN (LAR)
Authors:Nam, H.-J., Poy, F., Krueger, N., Saito, H., Frederick, C.A.
Deposit date:1999-04-20
Release date:2000-04-25
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the tandem phosphatase domains of RPTP LAR.
Cell(Cambridge,Mass.), 97, 1999
1M27
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CRYSTAL STRUCTURE OF SAP/FYNSH3/SLAM TERNARY COMPLEX
Descriptor:SH2 domain protein 1A, Signaling lymphocytic activation molecule, Proto-oncogene tyrosine-protein kinase FYN, ...
Authors:Chan, B., Griesbach, J., Song, H.K., Poy, F., Terhorst, C., Eck, M.J.
Deposit date:2002-06-21
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SAP couples Fyn to SLAM immune receptors.
NAT.CELL BIOL., 5, 2003
1UX4
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CRYSTAL STRUCTURES OF A FORMIN HOMOLOGY-2 DOMAIN REVEAL A TETHERED-DIMER ARCHITECTURE
Descriptor:BNI1 PROTEIN
Authors:Xu, Y., Moseley, J.B., Sagot, I., Poy, F., Pellman, D., Goode, B.L., Eck, M.J.
Deposit date:2004-02-19
Release date:2004-03-11
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Cell(Cambridge,Mass.), 116, 2004
1UX5
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CRYSTAL STRUCTURES OF A FORMIN HOMOLOGY-2 DOMAIN REVEAL A FLEXIBLY TETHERED DIMER ARCHITECTURE
Descriptor:BNI1 PROTEIN
Authors:Xu, Y., Moseley, J.B., Sagot, I., Poy, F., Pellman, D., Goode, B.L., Eck, M.J.
Deposit date:2004-02-19
Release date:2004-03-11
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Cell(Cambridge,Mass.), 116, 2004
1YGR
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CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAIN OF RPTP CD45
Descriptor:CD45 Protein Tyrosine Phosphatase, T-cell Receptor CD3 zeta ITAM-1
Authors:Nam, H.J., Poy, F., Saito, H., Frederick, C.A.
Deposit date:2005-01-05
Release date:2005-02-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
J.Exp.Med., 201, 2005
1YGU
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CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP CD45 WITH A PTYR PEPTIDE
Descriptor:Leukocyte common antigen, Polyoma Middle T antigen
Authors:Nam, H., Poy, F., Saito, H., Frederick, C.A.
Deposit date:2005-01-05
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
J.Exp.Med., 201, 2005
2AEH
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FOCAL ADHESION KINASE 1
Descriptor:Focal adhesion kinase 1
Authors:Ceccarelli, D.F., Song, H.K., Poy, F., Schaller, M.D., Eck, M.J.
Deposit date:2005-07-22
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
2AL6
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FERM DOMAIN OF FOCAL ADHESION KINASE
Descriptor:Focal adhesion kinase 1
Authors:Ceccarelli, D.F., Song, H.K., Poy, F., Schaller, M.D., Eck, M.J.
Deposit date:2005-08-04
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
2F31
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CRYSTAL STRUCTURE OF THE AUTOINHIBITORY SWITCH IN FORMIN MDIA1; THE DID/DAD COMPLEX
Descriptor:Diaphanous protein homolog 1
Authors:Nezami, A.G., Poy, F., Eck, M.J.
Deposit date:2005-11-18
Release date:2006-05-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the Autoinhibitory Switch in Formin mDia1
Structure, 14, 2006
2J1D
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CRYSTALLIZATION OF HDAAM1 C-TERMINAL FRAGMENT
Descriptor:DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1, PHOSPHATE ION, GLYCEROL
Authors:Lu, J., Meng, W., Poy, F., Eck, M.J.
Deposit date:2006-08-10
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Fh2 Domain of Daam1: Implications for Formin Regulation of Actin Assembly.
J.Mol.Biol., 369, 2007
4LR6
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STRUCTURE OF BRD4 BROMODOMAIN 1 WITH A 3-METHYL-4-PHENYLISOXAZOL-5-AMINE FRAGMENT
Descriptor:Bromodomain-containing protein 4, FORMIC ACID, 3-methyl-4-phenyl-1,2-oxazol-5-amine
Authors:Jayaram, H., Poy, F., Gehling, V., Hewitt, M., Vaswani, R., Leblanc, Y., Cote, A., Nasveschuk, C., Taylor, A., Harmange, J.-C., Audia, J., Pardo, E., Joshi, S., Sandy, P., Mertz, J., Sims, R., Bergeron, L., Bryant, B., Ravichandran, S., Yellapuntala, S., Nandana, B.S., Birudukota, S., Albrecht, B., Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
4LRG
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STRUCTURE OF BRD4 BROMODOMAIN 1 WITH A DIMETHYL THIOPHENE ISOXAZOLE AZEPINE CARBOXAMIDE
Descriptor:Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-[1,2]oxazolo[5,4-c]thieno[2,3-e]azepin-6-yl]acetamide
Authors:Ravichandran, S., Jayaram, H., Poy, F., Gehling, V., Hewitt, M., Vaswani, R., Leblanc, Y., Cote, A., Nasveschuk, C., Taylor, A., Harmange, J.-C., Audia, J., Pardo, E., Joshi, S., Sandy, P., Mertz, J., Sims, R., Bergeron, L., Bryant, B., Yellapuntala, S., Nandana, B.S., Birudukota, S., Albrecht, B., Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
4X2I
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DISCOVERY OF BENZOTRIAZOLO DIAZEPINES AS ORALLY-ACTIVE INHIBITORS OF BET BROMODOMAINS: CRYSTAL STRUCTURE OF BRD4 WITH CPI-13
Descriptor:Bromodomain-containing protein 4, FORMIC ACID, (4R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine
Authors:Bellon, S.F., Jayaram, H., Poy, F.
Deposit date:2014-11-26
Release date:2015-11-11
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
Acs Med.Chem.Lett., 7, 2016
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