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6PGU

Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-076 and CoA

Summary for 6PGU
Entry DOI10.2210/pdb6pgu/pdb
DescriptorHistone acetyltransferase p300, COENZYME A, N-(thiophen-2-yl)acetamide, ... (4 entities in total)
Functional Keywordsep300, p300 acetyltransferase, chromatin modification, epigenetics, inhibitor, allosteric, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight76188.41
Authors
Gardberg, A.S.,Poy, F.,Setser, J. (deposition date: 2019-06-24, release date: 2019-10-23, Last modification date: 2021-12-22)
Primary citationGardberg, A.S.,Huhn, A.J.,Cummings, R.,Bommi-Reddy, A.,Poy, F.,Setser, J.,Vivat, V.,Brucelle, F.,Wilson, J.
Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
Struct Dyn., 6:054702-054702, 2019
Cited by
PubMed: 31649965
DOI: 10.1063/1.5119336
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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