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6PGU

Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-076 and CoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
B0004402molecular_functionhistone acetyltransferase activity
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues24
Detailsbinding site for residue COA A 1701
ChainResidue
ALEU1398
ATYR1446
ALYS1456
AILE1457
APRO1458
ALYS1459
AARG1462
ATRP1466
AHOH1817
AHOH1822
AHOH1844
AASP1399
AHOH1847
AHOH1851
AHOH1854
AHOH1911
AHOH1971
ASER1400
AARG1410
ATHR1411
ATYR1414
ATRP1436
APRO1439
APRO1440

site_idAC2
Number of Residues10
Detailsbinding site for residue OK7 A 1702
ChainResidue
ATYR1394
AHIS1434
AILE1435
ATRP1436
AILE1486
APRO1502
AASP1507
ATRP1509
APHE1596
AHOH1877

site_idAC3
Number of Residues28
Detailsbinding site for residue COA B 1701
ChainResidue
BLEU1398
BASP1399
BSER1400
BARG1410
BTHR1411
BTYR1414
BTRP1436
BCYS1438
BPRO1440
BTYR1446
BLYS1456
BILE1457
BPRO1458
BLYS1459
BARG1462
BTRP1466
BHOH1803
BHOH1810
BHOH1811
BHOH1820
BHOH1830
BHOH1841
BHOH1848
BHOH1854
BHOH1868
BHOH1909
BHOH1920
BHOH1937

site_idAC4
Number of Residues9
Detailsbinding site for residue OK7 B 1702
ChainResidue
BTYR1394
BHIS1434
BILE1435
BILE1486
BPRO1502
BASP1507
BTRP1509
BPHE1596
BHOH1869

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:24819397
ChainResidueDetails
AILE1457
AARG1462
ATRP1466
BLEU1398
BARG1410
BILE1457
BARG1462
BTRP1466
ALEU1398
AARG1410

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17065153
ChainResidueDetails
ALYS1336
ALYS1473
BLYS1336
BLYS1473

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546
ChainResidueDetails
ALYS1499
BLYS1499

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS1583
BLYS1583

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PDB entries from 2024-06-12

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