6PGU

Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-076 and CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone acetyltransferase p300	polymer	323	37185.5	2	UniProt (Q09472) Pfam (PF08214)	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300,p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300
2	C, E (A, B)	COENZYME A	non-polymer		767.5	2	Chemie (COA)
3	D, F (A, B)	N-(thiophen-2-yl)acetamide	non-polymer		141.2	2	Chemie (OK7)
4	G, H (A, B)	water	water		18.0	459	Chemie (HOH)

Sequence modifications

A, B: 1287 - 1575 (UniProt: Q09472)

PDB	External Database	Details
Gly 1285	-	expression tag
Ser 1286	-	expression tag
Phe 1467	Tyr 1467	engineered mutation

A, B: 1582 - 1663 (UniProt: Q09472)

PDB	External Database	Details
Ser 1576	-	linker
Gly 1577	-	linker
Gly 1578	-	linker
Ser 1579	-	linker
Gly 1580	-	linker
Ser 1581	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74371.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1817.5
All*	Total formula weight	76188.4

*Water molecules are not included.