Author results

2HRB
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CRYSTAL STRUCTURE OF HUMAN CARBONYL REDUCTASE 3, COMPLEXED WITH NADP+
Descriptor:Carbonyl reductase [NADPH] 3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Pilka, E.S., Structural Genomics Consortium (SGC)
Deposit date:2006-07-20
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+
To be Published
2OBV
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CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT
Descriptor:S-adenosylmethionine synthetase isoform type-1, SODIUM ION, S-ADENOSYLMETHIONINE, ...
Authors:Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-02
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
2OME
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CRYSTAL STRUCTURE OF HUMAN CTBP2 DEHYDROGENASE COMPLEXED WITH NAD(H)
Descriptor:C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Pilka, E.S., Guo, K., Rojkova, A., Debreczeni, J.E., Kavanagh, K.L., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-01-22
Release date:2007-02-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)
To be Published
2PN8
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CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 4 (THIOREDOXIN PEROXIDASE)
Descriptor:Peroxiredoxin-4
Authors:Pilka, E.S., Kavanagh, K.L., Cooper, C., von Delft, F., Sundstrom, M., Arrowsmith, C.A., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-04-24
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase).
To be Published
2Q9V
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CRYSTAL STRUCTURE OF THE C890S MUTANT OF THE 4TH PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Authors:Pilka, E.S., Hozjan, V., Kavanagh, K.L., Papagrigoriou, E., Cooper, C., Elkins, J.M., Doyle, D.A., von Delft, F., Sundstrom, M., Arrowsmith, C.A., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-06-14
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the C890S mutant of the 4th PDZ domain of human membrane associated guanylate kinase.
To be Published
2QQ5
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CRYSTAL STRUCTURE OF HUMAN SDR FAMILY MEMBER 1
Descriptor:Dehydrogenase/reductase SDR family member 1
Authors:Pilka, E.S., Hozjan, V., Ugochukwu, E., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human SDR family member 1.
TO BE PUBLISHED
2R37
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 3 (SELENOCYSTEINE TO GLYCINE MUTANT)
Descriptor:Glutathione peroxidase 3, CHLORIDE ION, SODIUM ION
Authors:Pilka, E.S., Guo, K., Gileadi, O., Rojkowa, A., von Delft, F., Pike, A.C.W., Kavanagh, K.L., Johannson, C., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-08-29
Release date:2007-09-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant).
TO BE PUBLISHED
3B7L
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND MINODRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
Authors:Pilka, E.S., Dunford, J.E., Guo, K., Pike, A.C.W., Kavanagh, K.L., von Delft, F., Ebetino, F.H., Arrowsmith, C.H., Edwards, A.M., Russell, R.G.G., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human farnesyl diphosphate synthase complexed with MG and minodronate.
TO BE PUBLISHED
3BPT
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CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COA HYDROLASE IN COMPLEX WITH QUERCETIN
Descriptor:3-hydroxyisobutyryl-CoA hydrolase, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, (2R)-3-HYDROXY-2-METHYLPROPANOIC ACID
Authors:Pilka, E.S., Phillips, C., King, O.N.F., Guo, K., von Delft, F., Pike, A.C.W., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-12-19
Release date:2008-01-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human beta-hydroxyisobutyryl-CoA hydrolase in complex with quercetin.
To be Published
3BPU
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CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE, C677S AND C709S DOUBLE MUTANT
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, ZINC ION
Authors:Pilka, E.S., Hozjan, V., Cooper, C., Pike, A.C.W., Elkins, J., Doyle, D.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-12-19
Release date:2008-01-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the 3rd PDZ domain of human membrane associated guanylate kinase, C677S and C709S double mutant.
To be Published
3CP6
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CRYSTAL STRUCTURE OF HUMAN FARNESYL DIPHOSPHATE SYNTHASE (T201A MUTANT) COMPLEXED WITH MG AND BIPHOSPHONATE INHIBITOR
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid)
Authors:Pilka, E.S., Dunford, J.E., Guo, K., Pike, A.C.W., von Delft, F., Barnett, B.L., Ebetino, F.H., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Russell, R.G.G., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.
To be Published
3DA2
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X-RAY STRUCTURE OF HUMAN CARBONIC ANHYDRASE 13 IN COMPLEX WITH INHIBITOR
Descriptor:Carbonic anhydrase 13, ZINC ION, N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide, ...
Authors:Pilka, E.S., Picaud, S.S., Yue, W.W., King, O.N.F., Bray, J.E., Filippakopoulos, P., Roos, A.K., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-05-28
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray structure of human carbonic anhydrase 13 in complex with inhibitor.
To be Published
3FE4
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE VI
Descriptor:Carbonic anhydrase 6, MAGNESIUM ION, GLYCEROL
Authors:Pilka, E.S., Kochan, G., Krysztofinska, E., Muniz, J., Yue, W.W., Roos, A.K., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-11-27
Release date:2008-12-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development
Biochem.Biophys.Res.Commun., 419, 2012
3ISQ
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CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE
Descriptor:4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, CHLORIDE ION, ...
Authors:Pilka, E.S., Shafqat, N., Cocking, R., Bray, J.E., Krojer, T., Pike, A.C.W., von Delft, F., Yue, W.W., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Kavanagh, K.L., Structural Genomics Consortium (SGC)
Deposit date:2009-08-27
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase
to be published
2GDZ
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CRYSTAL STRUCTURE OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE TYPE1, COMPLEXED WITH NAD+
Descriptor:NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Pilka, E.S., Guo, K., Kavanagh, K., Von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-03-17
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5, 2010
2JKV
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STRUCTURE OF HUMAN PHOSPHOGLUCONATE DEHYDROGENASE IN COMPLEX WITH NADPH AT 2.53A
Descriptor:6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Pilka, E.S., Kavanagh, K.L., von Delft, F., Muniz, J.R.C., Murray, J., Picaud, S., Guo, K., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2008-09-01
Release date:2009-09-01
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Structure of Human Phosphogluconate Dehydrogenase in Complex with Nadph at 2.53A
To be Published
2OQ6
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CRYSTAL STRUCTURE OF JMJD2A COMPLEXED WITH HISTONE H3 PEPTIDE TRIMETHYLATED AT LYS9
Descriptor:JmjC domain-containing histone demethylation protein 3A, synthetic peptide, NICKEL (II) ION, ...
Authors:Pilka, E.S., Ng, S.S., Kavanagh, K.L., McDonough, M.A., Savitsky, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Sundstrom, M., Schofield, C.J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-01-31
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
2OX0
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CRYSTAL STRUCTURE OF JMJD2A COMPLEXED WITH HISTONE H3 PEPTIDE DIMETHYLATED AT LYS9
Descriptor:JmjC domain-containing histone demethylation protein 3A, synthetic peptide, NICKEL (II) ION, ...
Authors:Pilka, E.S., Ng, S.S., Kavanagh, K.L., McDonough, M.A., Savitsky, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Sundstrom, M., Schofield, C.J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-02-19
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
3B7W
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A, WITH L64P MUTATION
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
3C5E
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH ATP
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
3DAY
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH AMP-CPP
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Yue, W.W., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wikstrom, M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-07-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
3EQ6
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN A TERNARY COMPLEX WITH PRODUCTS
Descriptor:Acyl-coenzyme A synthetase ACSM2A, ADENOSINE MONOPHOSPHATE, Butyryl Coenzyme A
Authors:Pilka, E.S., Kochan, G., Yue, W.W., Bhatia, C., Von delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-09-30
Release date:2008-10-28
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
J.Mol.Biol., 388, 2009
3GPC
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN A COMPLEX WITH COA
Descriptor:Acyl-coenzyme A synthetase ACSM2A, MAGNESIUM ION, COENZYME A
Authors:Pilka, E.S., Kochan, G.T., Yue, W.W., Bhatia, C., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-03-23
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
J.Mol.Biol., 388, 2009
1O9A
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SOLUTION STRUCTURE OF THE COMPLEX OF 1F12F1 FROM FIBRONECTIN WITH B3 FROM FNBB FROM S. DYSGALACTIAE
Descriptor:FIBRONECTIN, FIBRONECTIN BINDING PROTEIN
Authors:Schwarz-Linek, U., Werner, J.M., Pickford, A.R., Pilka, E.S., Gurusiddappa, S., Briggs, J.A.G., Hook, M., Campbell, I.D., Potts, J.R.
Deposit date:2002-12-11
Release date:2003-05-08
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper.
Nature, 423, 2003
2IZZ
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CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE
Descriptor:PYRROLINE-5-CARBOXYLATE REDUCTASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
Deposit date:2006-07-31
Release date:2006-08-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
To be Published
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