2OQ6

Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys9

Summary for 2OQ6

Entry DOI	10.2210/pdb2oq6/pdb
Related	2OQ7 2OS2 2OT7 2OX0
Descriptor	JmjC domain-containing histone demethylation protein 3A, synthetic peptide, NICKEL (II) ION, ... (6 entities in total)
Functional Keywords	double-stranded beta helix, demethylase, oxygenase, sgc, structural genomics, structural genomics consortium, oxidoreductase
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: O75164
Total number of polymer chains	4
Total formula weight	90975.00
Authors	Pilka, E.S.,Ng, S.S.,Kavanagh, K.L.,McDonough, M.A.,Savitsky, P.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Schofield, C.J.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2007-01-31, release date: 2007-03-13, Last modification date: 2023-12-27)
Primary citation	Ng, S.S.,Kavanagh, K.L.,McDonough, M.A.,Butler, D.,Pilka, E.S.,Lienard, B.M.,Bray, J.E.,Savitsky, P.,Gileadi, O.,von Delft, F.,Rose, N.R.,Offer, J.,Scheinost, J.C.,Borowski, T.,Sundstrom, M.,Schofield, C.J.,Oppermann, U. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature, 448:87-91, 2007 Cited by PubMed: 17589501 DOI: 10.1038/nature05971 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation