Author results

1OIX
  • Download 1oix
  • View 1oix
Molmil generated image of 1oix
X-RAY STRUCTURE OF THE SMALL G PROTEIN RAB11A IN COMPLEX WITH GDP AND PI
Descriptor:RAS-RELATED PROTEIN RAB-11A, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ...
Authors:Pasqualato, S., Senic-Matuglia, F., Renault, L., Goud, B., Salamero, J., Cherfils, J.
Deposit date:2003-06-26
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallographic Evidence for Substrate-Assisted GTP Hydrolysis by a Small GTP Binding Protein
Structure, 13, 2005
1OIV
  • Download 1oiv
  • View 1oiv
Molmil generated image of 1oiv
X-RAY STRUCTURE OF THE SMALL G PROTEIN RAB11A IN COMPLEX WITH GDP
Descriptor:RAS-RELATED PROTEIN RAB-11A, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Pasqualato, S., Senic-Matuglia, F., Renault, L., Goud, B., Salamero, J., Cherfils, J.
Deposit date:2003-06-26
Release date:2004-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes
J.Biol.Chem., 279, 2004
1OIW
  • Download 1oiw
  • View 1oiw
Molmil generated image of 1oiw
X-RAY STRUCTURE OF THE SMALL G PROTEIN RAB11A IN COMPLEX WITH GTPGAMMAS
Descriptor:RAS-RELATED PROTEIN RAB-11A, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Pasqualato, S., Senic-Matuglia, F., Renault, L., Goud, B., Salamero, J., Cherfils, J.
Deposit date:2003-06-26
Release date:2004-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes
J.Biol.Chem., 279, 2004
2J5X
  • Download 2j5x
  • View 2j5x
Molmil generated image of 2j5x
STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS
Descriptor:ADP-RIBOSYLATION FACTOR 6, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Pasqualato, S., Menetrey, J., Franco, M., Cherfils, J.
Deposit date:2006-09-20
Release date:2006-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structural Gdp-GTP Cycle of Human Arf6.
Embo Rep., 2, 2001
1E7Z
  • Download 1e7z
  • View 1e7z
Molmil generated image of 1e7z
CRYSTAL STRUCTURE OF THE EMAP2/RNA BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX
Descriptor:ENDOTHELIAL-MONOCYTE ACTIVATING POLYPEPTIDE II, MERCURY (II) ION
Authors:Pasqualato, S., Kerjan, P., Renault, L., Menetrey, J., Mirande, M., Cherfils, J.
Deposit date:2000-09-13
Release date:2000-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the Emapii Domain of Human Aminoacyl-tRNA Synthetase Complex Reveals Evolutionary Dimeric Mimicry
Embo J., 20, 2001
1FL0
  • Download 1fl0
  • View 1fl0
Molmil generated image of 1fl0
CRYSTAL STRUCTURE OF THE EMAP2/RNA-BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX
Descriptor:ENDOTHELIAL-MONOCYTE ACTIVATING POLYPEPTIDE II
Authors:Renault, L., Kerjan, P., Pasqualato, S., Menetrey, J., Robinson, J.-C., Kawaguchi, S., Vassylyev, D.G., Yokoyama, S., Mirande, M., Cherfils, J.
Deposit date:2000-08-11
Release date:2000-12-06
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry.
EMBO J., 20, 2001
4BBN
  • Download 4bbn
  • View 4bbn
Molmil generated image of 4bbn
NEDD4 HECT-UB:UB COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B
Authors:Maspero, E., Valentini, E., Mari, S., Cecatiello, V., Polo, S., Pasqualato, S.
Deposit date:2012-09-27
Release date:2013-05-01
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
4BE8
  • Download 4be8
  • View 4be8
Molmil generated image of 4be8
NEDD4 HECT A889F STRUCTURE
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4
Authors:Maspero, E., Valentini, E., Mari, S., Cecatiello, V., Polo, S., Pasqualato, S.
Deposit date:2013-03-06
Release date:2013-05-01
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.996 Å)
Cite:Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
4NF9
  • Download 4nf9
  • View 4nf9
Molmil generated image of 4nf9
STRUCTURE OF THE KNL1/NSL1 COMPLEX
Descriptor:Protein CASC5, Kinetochore-associated protein NSL1 homolog, CHLORIDE ION
Authors:Petrovic, A., Mosalaganti, S., Keller, J., Mattiuzzo, M., Overlack, K., Wohlgemuth, S., Pasqualato, S., Raunser, S., Musacchio, A.
Deposit date:2013-10-31
Release date:2014-03-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization.
Mol.Cell, 53, 2014
4NFA
  • Download 4nfa
  • View 4nfa
Molmil generated image of 4nfa
STRUCTURE OF THE C-TERMINAL DOAMIN OF KNL1
Descriptor:Protein CASC5, CHLORIDE ION, GLYCEROL
Authors:Petrovic, A., Mosalaganti, S., Keller, J., Mattiuzzo, M., Overlack, K., Wohlgemuth, S., Pasqualato, S., Raunser, S., Musacchio, A.
Deposit date:2013-10-31
Release date:2014-03-19
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization.
Mol.Cell, 53, 2014
4P0T
  • Download 4p0t
  • View 4p0t
Molmil generated image of 4p0t
CRYSTAL STRUCTURE OF HUMAN CENTROMERE PROTEIN M
Descriptor:Centromere protein M, GLYCEROL
Authors:Basilico, F., Pasqualato, S., Musacchio, A.
Deposit date:2014-02-22
Release date:2014-07-09
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.493 Å)
Cite:The pseudo GTPase CENP-M drives human kinetochore assembly.
Elife, 3, 2014
2XBB
  • Download 2xbb
  • View 2xbb
Molmil generated image of 2xbb
NEDD4 HECT:UB COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4, UBIQUITIN, GLYCEROL
Authors:Maspero, E., Cecatiello, V., Musacchio, A., Polo, S., Pasqualato, S.
Deposit date:2010-04-08
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
2XBF
  • Download 2xbf
  • View 2xbf
Molmil generated image of 2xbf
NEDD4 HECT STRUCTURE
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4, 1,2-ETHANEDIOL, CALCIUM ION
Authors:Maspero, E., Cecatiello, V., Musacchio, A., Polo, S., Pasqualato, S.
Deposit date:2010-04-09
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
4WAU
  • Download 4wau
  • View 4wau
Molmil generated image of 4wau
CRYSTAL STRUCTURE OF CENP-M SOLVED BY NATIVE-SAD PHASING
Descriptor:Centromere protein M
Authors:Weinert, T., Basilico, F., Cecatiello, V., Pasqualato, S., Wang, M.
Deposit date:2014-09-01
Release date:2014-12-10
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
5LHG
  • Download 5lhg
  • View 5lhg
Molmil generated image of 5lhg
STRUCTURE OF THE KDM1A/COREST COMPLEX WITH THE INHIBITOR 4-METHYL-N-[4-[[4-(1-METHYLPIPERIDIN-4-YL)OXYPHENOXY]METHYL]PHENYL]THIENO[3,2-B]PYRROLE-5-CARBOXAMIDE
Descriptor:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Cecatiello, V., Pasqualato, S.
Deposit date:2016-07-11
Release date:2017-02-22
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LHH
  • Download 5lhh
  • View 5lhh
Molmil generated image of 5lhh
STRUCTURE OF THE KDM1A/COREST COMPLEX WITH THE INHIBITOR 4-ETHYL-N-[3-(METHOXYMETHYL)-2-[[4-[[(3R)-PYRROLIDIN-3-YL]METHOXY]PHENOXY]METHYL]PHENYL]THIENO[3,2-B]PYRROLE-5-CARBOXAMIDE
Descriptor:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Cecatiello, V., Pasqualato, S.
Deposit date:2016-07-11
Release date:2017-02-22
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LHI
  • Download 5lhi
  • View 5lhi
Molmil generated image of 5lhi
STRUCTURE OF THE KDM1A/COREST COMPLEX WITH THE INHIBITOR N-[3-(ETHOXYMETHYL)-2-[[4-[[(3R)-PYRROLIDIN-3-YL]METHOXY]PHENOXY]METHYL]PHENYL]-4-METHYLTHIENO[3,2-B]PYRROLE-5-CARBOXAMIDE
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Cecatiello, V., Pasqualato, S.
Deposit date:2016-07-12
Release date:2017-02-22
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
1KU1
  • Download 1ku1
  • View 1ku1
Molmil generated image of 1ku1
CRYSTAL STRUCTURE OF THE SEC7 DOMAIN OF YEAST GEA2
Descriptor:ARF guanine-nucleotide exchange factor 2
Authors:Renault, L., Christova, P., Guibert, B., Pasqualato, S., Cherfils, J.
Deposit date:2002-01-20
Release date:2002-03-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mechanism of domain closure of Sec7 domains and role in BFA sensitivity.
Biochemistry, 41, 2002
2VE7
  • Download 2ve7
  • View 2ve7
Molmil generated image of 2ve7
CRYSTAL STRUCTURE OF A BONSAI VERSION OF THE HUMAN NDC80 COMPLEX
Descriptor:KINETOCHORE PROTEIN HEC1, KINETOCHORE PROTEIN SPC25, KINETOCHORE PROTEIN NUF2, ...
Authors:Ciferri, C., Pasqualato, S., Dos Reis, G., Screpanti, E., Maiolica, A., Polka, J., De Luca, J.G., De Wulf, P., Salek, M., Rappsilber, J., Moores, C.A., Salmon, E.D., Musacchio, A.
Deposit date:2007-10-17
Release date:2008-05-13
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex
Cell(Cambridge,Mass.), 133, 2008
3IZ0
  • Download 3iz0
  • View 3iz0
Molmil generated image of 3iz0
HUMAN NDC80 BONSAI DECORATED MICROTUBULE
Descriptor:alpha tubulin, Chain A from PDB 1JFF, beta tubulin, ...
Authors:Alushin, G.M., Ramey, V.H., Pasqualato, S., Ball, D.A., Grigorieff, N., Musacchio, A., Nogales, E.
Deposit date:2010-08-09
Release date:2010-10-13
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Nature, 467, 2010
5FJH
  • Download 5fjh
  • View 5fjh
Molmil generated image of 5fjh
CRYSTAL STRUCTURE OF HUMAN JMJD2C CATALYTIC DOMAIN IN COMPLEX WITH EPITHERAPUETIC COMPOUND 2-(((2-((2-(DIMETHYLAMINO)ETHYL) (ETHYL)AMINO) -2-OXOETHYL)AMINO)METHYL)ISONICOTINIC ACID
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4C, NICKEL (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ...
Authors:Cecatiello, V., Pasqualato, S.
Deposit date:2015-10-09
Release date:2015-10-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors
To be Published
5FJK
  • Download 5fjk
  • View 5fjk
Molmil generated image of 5fjk
CRYSTAL STRUCTURE OF HUMAN JMJD2C CATALYTIC DOMAIN IN COMPLEX 6-ETHYL- 5-METHYL-7-OXO-4,7-DIHYDROPYRAZOLO(1,5-A)PYRIMIDINE-3-CARBONITRILE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4C, ZINC ION, NICKEL (II) ION, ...
Authors:Cecatiello, V., Pasqualato, S.
Deposit date:2015-10-09
Release date:2015-10-21
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors
To be Published
4PGO
  • Download 4pgo
  • View 4pgo
Molmil generated image of 4pgo
CRYSTAL STRUCTURE OF HYPOTHETICAL PROTEIN PF0907 FROM PYROCOCCUS FURIOSUS SOLVED BY SULFUR SAD USING SWISS LIGHT SOURCE DATA
Descriptor:Uncharacterized protein, CHLORIDE ION
Authors:Weinert, T., Waltersperger, S., Olieric, V., Panepucci, E., Chen, L., Rose, J.P., Wang, M., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2014-05-02
Release date:2014-12-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
4PII
  • Download 4pii
  • View 4pii
Molmil generated image of 4pii
CRYSTAL STRUCTURE OF HYPOTHETICAL PROTEIN PF0907 FROM PYROCOCCUS FURIOSUS SOLVED BY SULFUR SAD USING SWISS LIGHT SOURCE DATA
Descriptor:N-glycosylase/DNA lyase, CHLORIDE ION, IMIDAZOLE
Authors:Weinert, T., Waltersperger, S., Olieric, V., Panepucci, E., Chen, L., Rose, J.P., Wang, M., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2014-05-08
Release date:2014-12-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
4TN8
  • Download 4tn8
  • View 4tn8
Molmil generated image of 4tn8
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS THIOREDOXIN SOLVED BY SULFUR SAD USING SWISS LIGHT SOURCE DATA
Descriptor:Thioredoxin, CHLORIDE ION
Authors:Weinert, T., Waltersperger, S., Olieric, V., Panepucci, E., Chen, L., Rose, J.P., Wang, M., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2014-06-03
Release date:2014-12-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
<12>